Sublancin
Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS). Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM.
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- No. CAS: 207410-26-2
- Fòrmula: C162H254N50O51S5
- Peso molecular:3878.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Sublancin (0-500 μM, 24 h) inhibits methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 15 μM, and exhibits no cytotoxicity in RAW246.7 macrophage cells, mouse peritoneal macrophages, and human Caco-2 253 epithelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW246.7, Caco-2, P-Mac
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Concentration:0-500 μM
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Incubation Time:24 h
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Result:Maintained cell viability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Methicillin-resistant Staphylococcus aureus infected mice[1]
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Dosage:0.5-4 mg/kg
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Administration:ip, single dose
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Result:Improved the survival rate, reduced body weight loss.
Chemical Information
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No. CAS 207410-26-2
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Peso molecular 3878.38
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Fòrmula C162H254N50O51S5
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Sequence
Gly-Leu-Gly-Lys-Ala-Gln-Cys-Ala-Ala-Leu-Trp-Leu-Gln-Cys-Ala-Ser-Gly-Gly-Thr-Ile-Gly-{Cys(D-glucopyranosyl)}-Gly-Gly-Gly-Ala-Val-Ala-Cys-Gln-Asn-Tyr-Arg-Gln-Phe-Cys-Arg (disulfide bridge: Cys7-Cys36, Cys14-Cys29)
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Sequence Shortening
GLGKAQCAALWLQCASGGTIG-{Cys(D-glucopyranosyl)}-GGGAVACQNYRQFCR (disulfide bridge: Cys7-Cys36, Cys14-Cys29)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Wang S, et al., Use of the Antimicrobial Peptide Sublancin with Combined Antibacterial and Immunomodulatory Activities To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice. J Agric Food Chem. 2017 Oct 4;65(39):8595-8605. [Content Brief]
[2]. Wu C, et al., Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. 2019 Mar 8;5(3):454-459. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sublancin Related Classifications
HY-P10230 Related Classifications
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