VNT-101
Based on 1 Customer Validation
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection.
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- Pureza: 99.51%
- No. CAS: 2894060-67-2
- Fòrmula: C21H23F3N2O6
- Peso molecular:456.41
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
VNT-101 exhibits potent anti-influenza A virus activity in RNP assay, with EC50 = 45 nM against H1N1/California subtype and EC50 = 21 nM against H3N2/Alaska subtype[1].
VNT-101 shows strong inhibitory effect on viral neuraminidase in NA assay, with EC50 = 8 nM against H1N1/PR8 subtype and EC50 = 4 nM against H3N2/Alaska subtype[1].
VNT-101 effectively suppresses virus-induced cytopathic effect in CPE assay, with EC50 = 5 nM against H1N1/PR8 subtype and EC50 = 4 nM against H3N2/Alaska subtype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUCinf | Cmax | CL | Vss | T1/2 | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|
| Dog[1] | 0.5 mg/kg | i.v. | 5.35 μM·h | 8.3 μM | 3.42 mL/min/kg | 3.22 L/kg | 16.7 h | / | / |
| Dog[1] | 2 mg/kg | p.o. | 6.38 μM·h | 1.58 μM | / | / | 15.6 h | 0.83 h | 30 % |
| Mice[1] | 20 mg/kg | p.o. | 52.6 μM·h | 35.1 μM | / | / | 1.87 h | 0.5 h | 28 % |
| Mice[1] | 5 mg/kg | i.v. | 46.7 μM·h | 338 μM | 3.91 mL/min/kg | 0.52 L/kg | 4.03 h | / | / |
| Rat[1] | 10 mg/kg | p.o. | 10.2 μM·h | 1.41 μM | / | / | 5.16 h | 2.13 h | 46 % |
| Rat[1] | 100 mg/kg | p.o. | 122 μM·h | 21.6 μM | / | / | 5.65 h | 1.5 h | 54 % |
| Rat[1] | 30 mg/kg | p.o. | 35.4 μM·h | 7.67 μM | / | / | 5.49 h | 0.42 h | 53 % |
| Rat[1] | 5 mg/kg | i.v. | 11.2 μM·h | 49.8 μM | 17.5 mL/min/kg | 1.68 L/kg | 3.77 h | / | / |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:H1N1/PR8 influenza A virus (1000 pfu in inoculum, twice the LD100) was intranasally infected into Balb/c mice to establish a lethal influenza infection model[1]
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Dosage:1, 3, 10, 30 mg/kg
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Administration:oral administration, twice daily for 5 days
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Result:Exerted effective anti-influenza activity in Balb/c mice infected with H1N1 virus.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2894060-67-2
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Appearance Solid
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Peso molecular 456.41
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Fòrmula C21H23F3N2O6
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Color White to off-white
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SMILES
COC[C@]1(COC[C@H](O1)COC2=CC=C(C(C=C3C(N)=O)=C(C(F)(F)F)NC3=O)C=C2)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (219.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1910 mL | 10.9551 mL | 21.9101 mL | 54.7753 mL |
| 5 mM | 0.4382 mL | 2.1910 mL | 4.3820 mL | 10.9551 mL | |
| 10 mM | 0.2191 mL | 1.0955 mL | 2.1910 mL | 5.4775 mL | |
| 15 mM | 0.1461 mL | 0.7303 mL | 1.4607 mL | 3.6517 mL | |
| 20 mM | 0.1096 mL | 0.5478 mL | 1.0955 mL | 2.7388 mL | |
| 25 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1910 mL | |
| 30 mM | 0.0730 mL | 0.3652 mL | 0.7303 mL | 1.8258 mL | |
| 40 mM | 0.0548 mL | 0.2739 mL | 0.5478 mL | 1.3694 mL | |
| 50 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0955 mL | |
| 60 mM | 0.0365 mL | 0.1826 mL | 0.3652 mL | 0.9129 mL | |
| 80 mM | 0.0274 mL | 0.1369 mL | 0.2739 mL | 0.6847 mL | |
| 100 mM | 0.0219 mL | 0.1096 mL | 0.2191 mL | 0.5478 mL |
VNT-101 Related Classifications
HY-175469 Related Classifications
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