Ethylmalonic acid-d3
Based on 1 Customer Validation
Ethylmalonic acid-d3 is the deuterium labeled Ethylmalonic acid (HY-34740). Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 70907-93-6
- Formula: C5H5D3O4
- Molecular Weight:135.13
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 70907-93-6
-
Unlabeled Cas 601-75-2
-
Appearance Solid
-
Molecular Weight 135.13
-
Formula C5H5D3O4
-
Color White to off-white
-
SMILES
O=C(O)C(CC([2H])([2H])[2H])C(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (1850.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26(2):168-78. [Content Brief]
[3]. Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28(5):771-7. [Content Brief]
[4]. Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35(2):298-305. [Content Brief]
[5]. Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10(5):e0126606. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.4003 mL | 37.0014 mL | 74.0028 mL | 185.0070 mL |
| 5 mM | 1.4801 mL | 7.4003 mL | 14.8006 mL | 37.0014 mL | |
| 10 mM | 0.7400 mL | 3.7001 mL | 7.4003 mL | 18.5007 mL | |
| 15 mM | 0.4934 mL | 2.4668 mL | 4.9335 mL | 12.3338 mL | |
| 20 mM | 0.3700 mL | 1.8501 mL | 3.7001 mL | 9.2504 mL | |
| 25 mM | 0.2960 mL | 1.4801 mL | 2.9601 mL | 7.4003 mL | |
| 30 mM | 0.2467 mL | 1.2334 mL | 2.4668 mL | 6.1669 mL | |
| 40 mM | 0.1850 mL | 0.9250 mL | 1.8501 mL | 4.6252 mL | |
| 50 mM | 0.1480 mL | 0.7400 mL | 1.4801 mL | 3.7001 mL | |
| 60 mM | 0.1233 mL | 0.6167 mL | 1.2334 mL | 3.0835 mL | |
| 80 mM | 0.0925 mL | 0.4625 mL | 0.9250 mL | 2.3126 mL | |
| 100 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8501 mL |
Powered by Bioz