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  4. Exaluren disulfate

Exaluren disulfate  (Synonyms: ELX-02 disulfate; NB-124 disulfate)

製品番号: HY-114231B 純度: ≥98.0%
COA 取扱説明書 Technical Support

Exaluren (ELX-02; NB-124) disulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren disulfate is used for the research of cystic fibrosis caused by nonsense mutations.

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Exaluren disulfate

Exaluren disulfate 構造式

CAS 番号 : 2244622-33-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 1463 在庫あり
Solution
10 mM * 1 mL in Water USD 1463 在庫あり
Solid
1 mg $550 在庫あり
5 mg $980 在庫あり
10 mg $1500 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of Exaluren disulfate:

Exaluren disulfate 関連抗体

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製品説明

Exaluren (ELX-02; NB-124) disulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren disulfate is used for the research of cystic fibrosis caused by nonsense mutations[1][2].

体外実験

Exaluren disulfate induces significant premature stop codon read-through with maintained native stop codon fidelity in DMS-114 cells, increasing p53 protein expression and reducing nonsense-mediated mRNA decay of TP53 mRNA[1].
Exaluren disulfate exhibits consistent nonsense mutation read-through activity and efficacy in human bronchial epithelial cells, Fischer rat thyroid cells, and a dual luciferase cystic fibrosis model[1].
Exaluren disulfate induces read-through of the CTNS W138X nonsense allele in human cystinosis fibroblasts, increasing cystinosin protein and CTNS mRNA levels while reducing half-cystine levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Exaluren disulfate 関連抗体
体内実験

Exaluren (30-60 mg/kg; s.c.; daily; 14 days) disulfate achieves superior CFTR functional rescue in a CF mouse model expressing a human CFTRG542X transgene[1].
Exaluren (10 mg/kg; s.c.; 7 injections over a 3-week period) disulfate reduces kidney cell cystine levels by 30% in CTNSY226X nonsense mutant mice without overt renal toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CF mouse model expressing a human CFTRG542X transgene[1]
Dosage: 30, 60 mg/kg
Administration: s.c.; daily; 14 days
Result: Achieved CFTR functional rescue superior to gentamicin and exhibited favorable pharmacodynamic properties.
分子量

678.68

分子式

C19H42N4O18S2
CAS 番号
Appearance

Solid

Color

Yellow to brown

SMILES

OS(=O)(O)=O.C[C@@H](O)[C@@]([C@@H](O)[C@H](O)[C@H]1N)([H])O[C@]1([H])O[C@H]([C@H](C[C@@H](N)[C@@H]2O)N)[C@]2([H])O[C@@H]3O[C@@]([C@@H](N)C)([H])[C@@H](O)[C@H]3O.OS(=O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (147.34 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4734 mL 7.3672 mL 14.7345 mL
5 mM 0.2947 mL 1.4734 mL 2.9469 mL
10 mM 0.1473 mL 0.7367 mL 1.4734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

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体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (147.34 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: ≥98.0%

COA (261 KB) HNMR (369 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4734 mL 7.3672 mL 14.7345 mL 36.8362 mL
5 mM 0.2947 mL 1.4734 mL 2.9469 mL 7.3672 mL
10 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6836 mL
15 mM 0.0982 mL 0.4911 mL 0.9823 mL 2.4557 mL
20 mM 0.0737 mL 0.3684 mL 0.7367 mL 1.8418 mL
25 mM 0.0589 mL 0.2947 mL 0.5894 mL 1.4734 mL
30 mM 0.0491 mL 0.2456 mL 0.4911 mL 1.2279 mL
40 mM 0.0368 mL 0.1842 mL 0.3684 mL 0.9209 mL
50 mM 0.0295 mL 0.1473 mL 0.2947 mL 0.7367 mL
60 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6139 mL
80 mM 0.0184 mL 0.0921 mL 0.1842 mL 0.4605 mL
100 mM 0.0147 mL 0.0737 mL 0.1473 mL 0.3684 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Exaluren disulfate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Exaluren disulfate2244622-33-9ELX-02 disulfate NB-124 disulfateDNA/RNA SynthesiseukaryoticribosomeselectiveglycosideERSGgeneticdiseasesnonsensemutationInhibitorinhibitorinhibit

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