2. Metabolic Enzyme/Protease
  3. FBPase
  4. FBPase-IN-2

FBPase-IN-2 (Compound HS36) is a covalent FBPase inhibitor with an IC50 value of 0.15 μM for wild-type FBPase. FBPase-IN-2 inhibits glucose production in primary mouse hepatocytes via gluconeogenesis modulation. FBPase-IN-2 can be used for the research of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

FBPase-IN-2

FBPase-IN-2 Chemical Structure

CAS No. : 127143-25-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

FBPase-IN-2 Related Antibodies

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Description

FBPase-IN-2 (Compound HS36) is a covalent FBPase inhibitor with an IC50 value of 0.15 μM for wild-type FBPase. FBPase-IN-2 inhibits glucose production in primary mouse hepatocytes via gluconeogenesis modulation. FBPase-IN-2 can be used for the research of type 2 diabetes mellitus[1].

IC50 & Target

IC50: 0.15 μM (FBPase)[1]
In Vitro

FBPase-IN-2 potently inhibits wild-type FBPase with an IC50 of 0.15 μM[1].
FBPase-IN-2 (HS36) (25-200 μM; 4 h) inhibits gluconeogenesis-driven glucose production in primary mouse hepatocytes, with an inhibition rate of 41% observed at the concentration of 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FBPase-IN-2 Related Antibodies
Molecular Weight

228.59

Formula

C8H5ClN2O4
CAS No.
Appearance

Solid

Color

yellow

SMILES

O=[N+](C1=CC=C(C=C1)/C=C([N+]([O-])=O)\Cl)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (109.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3746 mL 21.8732 mL 43.7464 mL
5 mM 0.8749 mL 4.3746 mL 8.7493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3746 mL 21.8732 mL 43.7464 mL 109.3661 mL
5 mM 0.8749 mL 4.3746 mL 8.7493 mL 21.8732 mL
10 mM 0.4375 mL 2.1873 mL 4.3746 mL 10.9366 mL
15 mM 0.2916 mL 1.4582 mL 2.9164 mL 7.2911 mL
20 mM 0.2187 mL 1.0937 mL 2.1873 mL 5.4683 mL
25 mM 0.1750 mL 0.8749 mL 1.7499 mL 4.3746 mL
30 mM 0.1458 mL 0.7291 mL 1.4582 mL 3.6455 mL
40 mM 0.1094 mL 0.5468 mL 1.0937 mL 2.7342 mL
50 mM 0.0875 mL 0.4375 mL 0.8749 mL 2.1873 mL
60 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.8228 mL
80 mM 0.0547 mL 0.2734 mL 0.5468 mL 1.3671 mL
100 mM 0.0437 mL 0.2187 mL 0.4375 mL 1.0937 mL
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FBPase-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FBPase-IN-2127143-25-3FBPasefructose-1,6-bisphosphataseC128N125S124type 2 diabetes mellitusR243R254primary mouse hepatocytesY258human FBPaseInhibitorinhibitorinhibit

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