FBPase-IN-2
Based on 1 Customer Validation
FBPase-IN-2 (Compound HS36) is a covalent FBPase inhibitor with an IC50 value of 0.15 μM for wild-type FBPase. FBPase-IN-2 inhibits glucose production in primary mouse hepatocytes via gluconeogenesis modulation. FBPase-IN-2 can be used for the research of type 2 diabetes mellitus.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 127143-25-3
- Formula: C8H5ClN2O4
- Molecular Weight:228.59
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-diabetic Compound Library
HY-L040
-
Metabolic Enzyme Compound Library
HY-L146
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Lactic Acid Metabolic Compound Library
HY-L204
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
IC50: 0.15 μM (FBPase)[1]
FBPase-IN-2 potently inhibits wild-type FBPase with an IC50 of 0.15 μM[1].
FBPase-IN-2 (HS36) (25-200 μM; 4 h) inhibits gluconeogenesis-driven glucose production in primary mouse hepatocytes, with an inhibition rate of 41% observed at the concentration of 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 127143-25-3
-
Appearance Solid
-
Molecular Weight 228.59
-
Formula C8H5ClN2O4
-
Color yellow
-
SMILES
O=[N+](C1=CC=C(C=C1)/C=C([N+]([O-])=O)\Cl)[O-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (109.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3746 mL | 21.8732 mL | 43.7464 mL | 109.3661 mL |
| 5 mM | 0.8749 mL | 4.3746 mL | 8.7493 mL | 21.8732 mL | |
| 10 mM | 0.4375 mL | 2.1873 mL | 4.3746 mL | 10.9366 mL | |
| 15 mM | 0.2916 mL | 1.4582 mL | 2.9164 mL | 7.2911 mL | |
| 20 mM | 0.2187 mL | 1.0937 mL | 2.1873 mL | 5.4683 mL | |
| 25 mM | 0.1750 mL | 0.8749 mL | 1.7499 mL | 4.3746 mL | |
| 30 mM | 0.1458 mL | 0.7291 mL | 1.4582 mL | 3.6455 mL | |
| 40 mM | 0.1094 mL | 0.5468 mL | 1.0937 mL | 2.7342 mL | |
| 50 mM | 0.0875 mL | 0.4375 mL | 0.8749 mL | 2.1873 mL | |
| 60 mM | 0.0729 mL | 0.3646 mL | 0.7291 mL | 1.8228 mL | |
| 80 mM | 0.0547 mL | 0.2734 mL | 0.5468 mL | 1.3671 mL | |
| 100 mM | 0.0437 mL | 0.2187 mL | 0.4375 mL | 1.0937 mL |
FBPase-IN-2 Related Classifications
HY-147645 Related Classifications
Powered by Bioz