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Cat. No.: HY-185455

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FEN1-IN-9

FEN1-IN-9 is a selective flap endonuclease 1 (FEN1) inhibitor with an IC₅₀ of 37.9 μM. FEN1-IN-9 can be used for the research of DNA damage repair.

For research use only. We do not sell to patients.

CAS No.: 758720-87-5
Formula: C₁₀H₆Cl₂O₄
Molecular Weight:261.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FEN1-IN-9 Chemical Structure

CAS No.: 758720-87-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

FEN1-IN-9 is a selective flap endonuclease 1 (FEN1) inhibitor with an IC₅₀ of 37.9 μM. FEN1-IN-9 can be used for the research of DNA damage repair^[1].

IC₅₀ & Target

^[1]

FEN1

37.9 μM (IC₅₀)

In Vitro

FEN1-IN-9 (Compound 12) inhibits purified FEN1 with an IC₅₀ of 37.9 μM and shows selectivity over purified XPG (IC₅₀ >100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 758720-87-5
Molecular Weight 261.06
Formula C₁₀H₆Cl₂O₄
SMILES

O=C(C(CC(C1=C(Cl)C=CC=C1Cl)=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tumey LN, et al. The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2004;14(19):4915-4918. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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