FLT3-IN-21
FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC50: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC50: 5.3 nM). In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%).
For research use only. We do not sell to patients.
- Formula: C20H22FN5O2
- Molecular Weight:383.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 8.4 nM (FLT3)[1]
Chemical Information
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Molecular Weight 383.42
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Formula C20H22FN5O2
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SMILES
CC1=C(NC=C1NC(NN2CCCCC2)=O)/C=C(C3=CC(F)=CC=C3N4)\C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645. [Content Brief]
[2]. Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645.. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLT3-IN-21 Related Classifications
HY-155226 Related Classifications
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