Didemnin B
Based on 1 publication(s) in Google Scholar
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 77327-05-0
- Formula: C57H89N7O15
- Molecular Weight:1112.35
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Didemnin B
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
| HT-29 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
| P388 | IC50 |
>1 μM
Compound: 27
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Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
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[PMID: 33592144] |
| P388 | IC50 |
0.1 μM
Compound: 27
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Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
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[PMID: 33592144] |
| P388 | IC50 |
0.4 μM
Compound: 27
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Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
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[PMID: 33592144] |
| P388 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
| SK-MEL-28 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
Didemnin B has activity against miirine B16 melanoma, P388 leukemia, and M5076 sarcoma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-Thr-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-Leu-Pro-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-T-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-LP-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
Chemical Information
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CAS No. 77327-05-0
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Appearance Solid
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Molecular Weight 1112.35
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Formula C57H89N7O15
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Color White to off-white
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SMILES
O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C([C@@H](O)C)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (89.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (287 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Portuguese - PT (537 KB)
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Handling Instructions (2659 KB)
References
[1]. Stewart JA, et al. A phase I clinical trial of didemnin B. Cancer. 1991;68(12):2550-2554. [Content Brief]
[2]. Li LH, Timmins LG, Wallace TL, Krueger WC, Prairie MD, Im WB. Mechanism of action of didemnin B, a depsipeptide from the sea. Cancer Lett. 1984;23(3):279-288. [Content Brief]
[3]. Grubb DR, Wolvetang EJ, Lawen A. Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described. Biochem Biophys Res Commun. 1995;215(3):1130-1136. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8990 mL | 4.4950 mL | 8.9900 mL | 22.4749 mL |
| 5 mM | 0.1798 mL | 0.8990 mL | 1.7980 mL | 4.4950 mL | |
| 10 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL | 2.2475 mL | |
| 15 mM | 0.0599 mL | 0.2997 mL | 0.5993 mL | 1.4983 mL | |
| 20 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1237 mL | |
| 25 mM | 0.0360 mL | 0.1798 mL | 0.3596 mL | 0.8990 mL | |
| 30 mM | 0.0300 mL | 0.1498 mL | 0.2997 mL | 0.7492 mL | |
| 40 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5619 mL | |
| 50 mM | 0.0180 mL | 0.0899 mL | 0.1798 mL | 0.4495 mL | |
| 60 mM | 0.0150 mL | 0.0749 mL | 0.1498 mL | 0.3746 mL | |
| 80 mM | 0.0112 mL | 0.0562 mL | 0.1124 mL | 0.2809 mL |
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