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Cat. No.: HY-152206

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JB062

JB062 is a nonmuscle myosin inhibitor with IC₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.

For research use only. We do not sell to patients.

CAS No.: 2417988-00-0
Formula: C₁₉H₁₇NO₄
Molecular Weight:323.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

JB062 Chemical Structure

CAS No.: 2417988-00-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II)^[1]

All Myosin Isoforms :

MLCK

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	CC₅₀	>200 μM Compound: 6b; JB062	Cytotoxicity against Green monkey COS-7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against Green monkey COS-7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 36543032]

In Vitro

JB062 (compound 6b; 40 μM; 24 h) inhibits cytokinesis in Cos-7 cells^[1].
JB062 (COS-7 cells) has cytotoxic to human cancer cells but not normal cells with a CC₁₀ value of 36 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2417988-00-0
Appearance Solid
Molecular Weight 323.34
Formula C₁₉H₁₇NO₄
Color White to off-white
SMILES

OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=C(OC)C=C3)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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JB062

All Myosin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JB062 Related Classifications

HY-152206 Related Classifications