m7GpppAmpG
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ cap analog. m7GpppAmpG binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG caps RNA with an efficiency of 90% and enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (m7GpppAmpG ammonium solution (100 mM)) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 62858-30-4
- Formula: C32H43N15O24P4
- Molecular Weight:1145.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of m7GpppAmpG
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
eIF4E 45.6 nM (Kd) |
In Vitro
Chemical Information
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CAS No. 62858-30-4
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Molecular Weight 1145.66
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Formula C32H43N15O24P4
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)(O)=O)[C@@H](COP(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C(N=C(N)N9)=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O)(O)=O)O3
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Synonyms
m7G(5')ppp(5')(2'OMeA)pG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48(4):1607-1626. [Content Brief]
[3]. Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024 Jan;44(1):101-126. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
m7GpppAmpG Related Classifications
HY-145974 Related Classifications
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