PEG300
(Synonyms: Polyethylene glycol 300)
212 Cited Publications
Customer Review
Based on 212 publication(s) in Google Scholar
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.
For research use only. We do not sell to patients.
- CAS No.: 25322-68-3
- Molecular Weight:300.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) PEG300
More- Signal Transduct Target Ther. 2025 Dec 24;10(1):417. [Abstract]
- Signal Transduct Target Ther. 2023 Sep 25;8(1):366. [Abstract]
- Nature. 2026 May;653(8113):254-264. [Abstract]
- Nature. 2026 Jan;649(8096):477-486. [Abstract]
- Cancer Cell. 2025 Aug 12:S1535-6108(25)00330-7. [Abstract]
- Science. 2025 Nov 13;390(6774):eadq1177. [Abstract]
- Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]
- Cell. 2021 Sep 2;184(18):4753-4771.e27. [Abstract]
- Mol Cancer. 2024 Apr 27;23(1):85. [Abstract]
- J Hepatol. 2023 Apr;78(4):754-769. [Abstract]
- Cell Metab. 2026 May 5;38(5):909-928.e8. [Abstract]
- Immunity. 2025 Nov 11;58(11):2864-2877.e9. [Abstract]
- Nat Metab. 2026 Jan;8(1):139-158. [Abstract]
- Nat Metab. 2025 Oct 21. [Abstract]
- Nat Aging. 2025 Mar;5(3):468-485. [Abstract]
- Cancer Res. 2021 Apr 1;81(7):1813-1826. [Abstract]
- Nat Microbiol. 2023 Jan;8(1):121-134. [Abstract]
- Autophagy. 2026 Jun 26:1-17. [Abstract]
- Autophagy. 2026 May 25:1-21. [Abstract]
- Autophagy. 2026 May;22(5):1021-1043. [Abstract]
- Nat Commun. 2025 Jan 3;16(1):289. [Abstract]
- Nat Commun. 2024 Jan 4;15(1):252. [Abstract]
- Nat Commun. 2023 May 24;14(1):2994. [Abstract]
- Nat Commun. 2023 May 19;14(1):2859. [Abstract]
- Nat Commun. 2021 May 10;12(1):2587. [Abstract]
- Int J Oral Sci. 2024 Jun 18;16(1):46. [Abstract]
- Redox Biol. 2025 Dec:88:103939. [Abstract]
- Redox Biol. 2025 May 8:84:103657. [Abstract]
- Nat Chem Biol. 2025 Sep 15. [Abstract]
- Theranostics. 2024 Aug 26;14(14):5429-5442. [Abstract]
- Biomark Res. 2023 Jan 24;11(1):8. [Abstract]
- J Biomed Sci. 2025 Mar 17;32(1):36. [Abstract]
- J Clin Invest. 2024 Jun 17;134(12):e177172. [Abstract]
- Adv Sci (Weinh). 2026 Apr 27:e23716. [Abstract]
- Adv Sci (Weinh). 2026 Jan 25:e11482. [Abstract]
- MedComm (2020). 2026 Jan 13;7(1):e70548. [Abstract]
- Adv Sci (Weinh). 2024 Jul;11(26):e2306348. [Abstract]
- MedComm. 2024 Apr 13;5(4):e537. [Abstract]
- Cell Rep Med. 2026 Jun 16;7(6):102833. [Abstract]
- Sci Adv. 2025 Oct 31;11(44):eaea1212. [Abstract]
- Sci Adv. 2025 Sep 26;11(39):eadq7665. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadx6587. [Abstract]
- Biomaterials. 2026 Aug:331:124126. [Abstract]
- Chem Eng J. 2025 Oct 15.
- Cell Commun Signal. 2026 Jun 23;24(1):370. [Abstract]
- Cell Commun Signal. 2024 Jan 18;22(1):53. [Abstract]
- J Neuroinflammation. 2024 Nov 14;21(1):295. [Abstract]
- Hemasphere. 2026 Jun 15;10(6):e70383. [Abstract]
- Phytomedicine. 2026 Apr:153:157937. [Abstract]
- Phytomedicine. 2025 Oct 13:148:157385. [Abstract]
- Phytomedicine. 2024 Jun:128:155425. [Abstract]
- Adv Healthc Mater. 2025 Jun 5:e2501642. [Abstract]
- Clin Cancer Res. 2025 Nov 13. [Abstract]
- Cell Death Discov. 2026 May 25. [Abstract]
- Cell Death Discov. 2025 Oct 6;11(1):445. [Abstract]
- Acta Pharmacol Sin. 2025 Aug 19. [Abstract]
- Environ Int. 2026 Feb:208:110128. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2536989123. [Abstract]
- Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2203480119. [Abstract]
- Apoptosis. 2026 Apr 29;31(5):132. [Abstract]
- Apoptosis. 2026 Jan 10;31(1):30. [Abstract]
- Cell Chem Biol. 2025 Jul 17;32(7):926-941.e23. [Abstract]
- Alzheimers Res Ther. 2025 Feb 14;17(1):43. [Abstract]
- Int J Biol Macromol. 2025 Oct 9;330(Pt 3):148223. [Abstract]
- Neural Regen Res. 2023 Aug;18(8):1818-1826. [Abstract]
- Antioxidants (Basel). 2026 May 18;15(5):639. [Abstract]
- Free Radic Biol Med. 2026 Mar 16:246:35-50. [Abstract]
- Free Radic Biol Med. 2025 Nov:239:116-129. [Abstract]
- Free Radic Biol Med. 2025 Feb 16:228:207-220. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:15-27. [Abstract]
- Am J Chin Med. 2026;54(4):1281-1307. [Abstract]
- Br J Cancer. 2026 May 18. [Abstract]
- Hepatol Int. 2024 Jun;18(3):1040-1052. [Abstract]
- Stem Cell Res Ther. 2023 Dec 20;14(1):333. [Abstract]
- Cell Rep. 2026 Jun 20;45(7):117583. [Abstract]
- Cell Rep. 2025 Sep 19;44(10):116326. [Abstract]
- Cell Rep. 2025 Jun 17;44(6):115843. [Abstract]
- Cell Rep. 2025 Jun 24;44(6):115834. [Abstract]
- Cell Rep. 2025 Apr 5;44(4):115541. [Abstract]
- Cell Rep. 2025 Apr 17;44(5):115605. [Abstract]
- Cell Rep. 2024 Dec 17;44(1):115072. [Abstract]
- Aging Cell. 2023 Aug;22(8):e13896. [Abstract]
- Cell Rep. 2023 Apr 20;42(5):112424. [Abstract]
- Cell Rep. 2023 Mar 30;42(4):112314. [Abstract]
- Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):4099-4110. [Abstract]
- Brain Behav Immun. 2025 Oct 23:131:106148. [Abstract]
- Br J Pharmacol. 2024 Dec 3. [Abstract]
- J Agric Food Res. 2025 Oct 27;24:102486.
- J Ethnopharmacol. 2026 Apr 6:360:121174. [Abstract]
- Antioxid Redox Signal. 2025 Dec 26. [Abstract]
- J Ethnopharmacol. 2024 Dec 23:119243. [Abstract]
- Neurosci Bull. 2023 Dec;39(12):1775-1788. [Abstract]
- J Ethnopharmacol. 2021 Jun 28:274:114078. [Abstract]
- J Agric Food Chem. 2026 Mar 4;74(8):7125-7138. [Abstract]
- Cell Mol Life Sci. 2026 Jan 7;83(1):60. [Abstract]
- Life Sci. 2025 May 21:123753. [Abstract]
- Life Sci. 2025 Apr 1:366-367:123476. [Abstract]
- Life Sci. 2024 Sep 16:123061. [Abstract]
- Food Funct. 2021 Feb 15;12(3):1207-1218. [Abstract]
- Liver Int. 2024 Mar;44(3):691-705. [Abstract]
- Hepatol Commun. 2026 Apr 24;10(5):e0928.
- Cells. 2024 Dec 6;13(23):2016. [Abstract]
- Foods. 2024 Apr 26;13(9):1336. [Abstract]
- Neurobiol Dis. 2023 Jun 1:181:106103. [Abstract]
- Commun Biol. 2026 May 28. [Abstract]
- Eur J Pharmacol. 2026 Jun 11:1030:178974. [Abstract]
- Eur J Pharmacol. 2025 Dec 23:1013:178508. [Abstract]
- Eur J Pharmacol. 2025 Feb 1:177329. [Abstract]
- Eur J Pharmacol. 2025 Feb 6:177359. [Abstract]
- Eur J Pharmacol. 2024 Jan 5:962:176171. [Abstract]
- Pharmaceuticals (Basel). 2023 Feb 17;16(2):316. [Abstract]
- Int Immunopharmacol. 2026 Jun 30:186:117067. [Abstract]
- Int J Mol Sci. 2026 Apr 9;27(8):3381. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 2):115892. [Abstract]
- Int Immunopharmacol. 2025 Apr 16:152:114428. [Abstract]
- Int Immunopharmacol. 2025 Jan 18:148:114086. [Abstract]
- Int Immunopharmacol. 2024 Sep 23;142(Pt B):113244. [Abstract]
- Int Immunopharmacol. 2024 Jun 25:138:112533. [Abstract]
- Biomolecules. 2024 Jun 19;14(6):726. [Abstract]
- Int Immunopharmacol. 2024 Mar 30:130:111680. [Abstract]
- Int J Mol Sci. 2023 Jun 9;24(12):9954. [Abstract]
- Int Immunopharmacol. 2023 Jan:114:109607. [Abstract]
- Int Immunopharmacol. 2022 Sep:110:109000. [Abstract]
- Mol Neurobiol. 2024 May;61(5):2949-2963. [Abstract]
- BMC Microbiol. 2026 Jun 9. [Abstract]
- Int J Obes. 2023 Apr;47(4):325-334. [Abstract]
- Front Pharmacol. 2021 Sep 13:12:733420. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Sep 2;1872(1):168030. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jun 9:167288. [Abstract]
- Sci Rep. 2026 Apr 18;16(1):17992. [Abstract]
- Sci Rep. 2025 Oct 16;15(1):36270. [Abstract]
- J Mol Struct. 2025 Oct 11;1351:144356.
- Mediators Inflamm. 2025 Feb 13:2025:7942947. [Abstract]
- Am J Pathol. 2024 Nov;194(11):2007-2022. [Abstract]
- Sci Rep. 2024 Apr 8;14(1):8241. [Abstract]
- Pestic Biochem Physiol. 2023 Dec:197:105647. [Abstract]
- Neuropharmacology. 2026 Aug 1:293:110965. [Abstract]
- Cell Signal. 2025 Aug 21:112066. [Abstract]
- J Cell Mol Med. 2021 Jun;25(12):5782-5798. [Abstract]
- J Inflamm Res. 2025 Nov 19:18:16231-16245. [Abstract]
- J Inflamm Res. 2025 Oct 10:18:14113-14129. [Abstract]
- J Neurochem. 2021 Sep;158(5):1110-1130. [Abstract]
- Brain Res Bull. 2025 Oct 3:232:111568. [Abstract]
- iScience. 2022 Aug 13;25(9):104936. [Abstract]
- iScience. 2022 Apr 18;25(5):104267. [Abstract]
- FASEB J. 2024 Nov 30;38(22):e70154. [Abstract]
- Front Biosci (Landmark Ed). 2026 May 22;31(5):49658. [Abstract]
- Bone. 2023 Mar:168:116648. [Abstract]
- J Med Virol. 2025 Sep;97(9):e70601. [Abstract]
- Mol Immunol. 2023 May:157:176-185. [Abstract]
- Toxicol Appl Pharmacol. 2026 Jun 15:514:117911. [Abstract]
- Toxicol Appl Pharmacol. 2025 Dec 8:507:117682. [Abstract]
- Dis Model Mech. 2024 Oct 1;17(10):dmm050900. [Abstract]
- J Reprod Immunol. 2025 Jul 27:171:104630. [Abstract]
- Arch Biochem Biophys. 2025 Jan 21:765:110316. [Abstract]
- Arch Biochem Biophys. 2022 Sep 30:727:109325. [Abstract]
- J Cancer. 2024 Jun 11;15(13):4406-4416. [Abstract]
- Animal Model Exp Med. 2026 Jun 12. [Abstract]
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- J Integr Neurosci. 2025 Jun 19;24(6):37182. [Abstract]
- Biol Reprod. 2026 Jan 19:ioag014. [Abstract]
- Immunopharmacol Immunotoxicol. 2025 Oct;47(5):716-726. [Abstract]
- Exp Eye Res. 2025 Oct:259:110509. [Abstract]
- Acta Diabetol. 2025 May 12. [Abstract]
- Placenta. 2025 May 2:164:21-30. [Abstract]
- J Pain Res. 2021 Oct 18;14:3289-3299. [Abstract]
- Front Cardiovasc Med. 2022 Jun 2;9:907747. [Abstract]
- PeerJ. 2024 Nov 15:12:e18507. [Abstract]
- PLoS One. 2026 Jun 12;21(6):e0351107. [Abstract]
- Vet Microbiol. 2025 Dec 2:312:110827. [Abstract]
- PLoS One. 2025 Jun 27;20(6):e0326687. [Abstract]
- Dig Dis Sci. 2025 Jun 24. [Abstract]
- Discov Oncol. 2025 May 8;16(1):690. [Abstract]
- FEBS Open Bio. 2022 Oct;12(10):1761-1770. [Abstract]
- Addict Biol. 2024 Mar;29(3):e13382. [Abstract]
- Clin Exp Pharmacol Physiol. 2026 Feb;53(2):e70106. [Abstract]
- Mol Imaging Biol. 2022 Dec;24(6):959-972. [Abstract]
- Epilepsy Res. 2023 Jul:193:107161. [Abstract]
- J Cardiothorac Surg. 2024 May 10;19(1):283. [Abstract]
- Transplant Proc. 2025 Aug 11:S0041-1345(25)00350-1. [Abstract]
- SSRN. 2026 Jun 16.
- bioRxiv. 2026 Jun 24.
- bioRxiv. 2026 May 26:2026.05.26.725122. [Abstract]
- bioRxiv. 2026 May 19.
- Res Sq. 2026 Apr 16.
- bioRxiv. 2026 Mar 5:2026.03.04.708749. [Abstract]
- ArXiv. 2026 Mar 3.
- bioRxiv. 2026 Feb 12:2026.02.10.705144. [Abstract]
- Res Sq. 2026 Jan 23.
- Patent. US20250319053A1.
- SSRN. 2025 Sep 19.
- bioRxiv. 2025 Mar 27:2025.03.24.645104. [Abstract]
- bioRxiv. 2025 April 24.
- hLife. 2025 Jan 25.
- Res Sq. 2024 May 29.
- University of Minnesota. 2024.
- Res Sq. 2024 Jun 26.
- SSRN. 2024 Apr 18.
- bioRxiv. 2024 Mar 8.
- bioRxiv. 2024 Jan 24.
- Biomed Pharmacother. 2024 Feb:171:116194. [Abstract]
- Heliyon. 2024 Jan 18;10(3):e24988. [Abstract]
- Research Square Preprint. 2023 Dec 1.
- University of Michigan. 2023 Sep.
- Western University. 2023 Aug 22.
- Research Square Preprint. 2023 Sep 8.
- Research Square Preprint. 2023 Jun 28.
- Universidad de Granada. 2023 Mar 27.
- Research Square Print. 2023 Mar 23.
- Biomed Pharmacother. 2023 Jan:157:114030. [Abstract]
- Biomed Pharmacother. 2022 Nov:155:113669. [Abstract]
- Research Square Print. 2022 Aug.
Biological Activity
Description
In Vitro
The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25322-68-3
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Appearance Liquid (Density: 1.127 g/cm3)
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Molecular Weight 300.00
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Color Colorless to light yellow
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SMILES
[H]OCCO[H].[n]
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Synonyms
Polyethylene glycol 300
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (212)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancer. [Abstract]2025 Dec 24;10(1):417. PMID: 41436606 -
Signal Transduct Target Ther
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. [Abstract]2023 Sep 25;8(1):366. PMID: 37743418 -
Nature
2026 May;653(8113):254-264. PMID: 42020743 -
Nature
2026 Jan;649(8096):477-486. PMID: 41193799 -
Cancer Cell
2025 Aug 12:S1535-6108(25)00330-7. PMID: 40829591 -
Science
2025 Nov 13;390(6774):eadq1177. PMID: 41231983 -
Cell
2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018 -
Cell
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. [Abstract]2021 Sep 2;184(18):4753-4771.e27. PMID: 34388391 -
Mol Cancer
2024 Apr 27;23(1):85. PMID: 38678233 -
J Hepatol
Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease. [Abstract]2023 Apr;78(4):754-769. PMID: 36681161 -
Cell Metab
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice. [Abstract]2026 May 5;38(5):909-928.e8. PMID: 41780522 -
Immunity
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors. [Abstract]2025 Nov 11;58(11):2864-2877.e9. PMID: 41175874 -
Nat Metab
Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes. [Abstract]2026 Jan;8(1):139-158. PMID: 41482566 -
Nat Metab
Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation. [Abstract]2025 Oct 21. PMID: 41120706 -
Nat Aging
2025 Mar;5(3):468-485. PMID: 39779911 -
Cancer Res
Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. [Abstract]2021 Apr 1;81(7):1813-1826. PMID: 33495232 -
Nat Microbiol
2023 Jan;8(1):121-134. PMID: 36604514 -
Autophagy
Chaperone-mediated autophagy reprograms heterogeneous subsets of activated macrophages in immune thrombocytopenia. [Abstract]2026 Jun 26:1-17. PMID: 42329073 -
Autophagy
Byakangelicin alleviates metabolic dysfunction-associated steatohepatitis by selective inhibition of a non-canonical MTORC1 signaling pathway. [Abstract]2026 May 25:1-21. PMID: 42152469 -
Autophagy
Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization. [Abstract]2026 May;22(5):1021-1043. PMID: 41692957 -
Nat Commun
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway. [Abstract]2025 Jan 3;16(1):289. PMID: 39753529 -
Nat Commun
Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. [Abstract]2024 Jan 4;15(1):252. PMID: 38177117 -
Nat Commun
2023 May 24;14(1):2994. PMID: 37225695 -
Nat Commun
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]2023 May 19;14(1):2859. PMID: 37208329 -
Nat Commun
An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. [Abstract]2021 May 10;12(1):2587. PMID: 33972537 -
Int J Oral Sci
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma. [Abstract]2024 Jun 18;16(1):46. PMID: 38886342 -
Redox Biol
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence. [Abstract]2025 Dec:88:103939. PMID: 41308252 -
Redox Biol
Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions. [Abstract]2025 May 8:84:103657. PMID: 40393152 -
Nat Chem Biol
2025 Sep 15. PMID: 40954224 -
Theranostics
2024 Aug 26;14(14):5429-5442. PMID: 39310100 -
Biomark Res
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia. [Abstract]2023 Jan 24;11(1):8. PMID: 36691065 -
J Biomed Sci
Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4. [Abstract]2025 Mar 17;32(1):36. PMID: 40091020 -
J Clin Invest
Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models. [Abstract]2024 Jun 17;134(12):e177172. PMID: 38950288 -
Adv Sci (Weinh)
Microglia-Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis-Associated Encephalopathy. [Abstract]2026 Apr 27:e23716. PMID: 42037180 -
Adv Sci (Weinh)
Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke. [Abstract]2026 Jan 25:e11482. PMID: 41580979 -
MedComm (2020)
Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation. [Abstract]2026 Jan 13;7(1):e70548. PMID: 41536519 -
Adv Sci (Weinh)
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape. [Abstract]2024 Jul;11(26):e2306348. PMID: 38696655 -
MedComm
2024 Apr 13;5(4):e537. PMID: 38617434 -
Cell Rep Med
Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]2026 Jun 16;7(6):102833. PMID: 42173096 -
Sci Adv
Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor. [Abstract]2025 Oct 31;11(44):eaea1212. PMID: 41160695 -
Sci Adv
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling. [Abstract]2025 Sep 26;11(39):eadq7665. PMID: 40991686 -
Sci Adv
2025 Aug 15;11(33):eadx6587. PMID: 40815641 -
Biomaterials
Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming. [Abstract]2026 Aug:331:124126. PMID: 41830766 -
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Cell Commun Signal
Glucose transport dependency defines a therapeutic vulnerability in JAK2V617F-driven myeloproliferative neoplasms. [Abstract]2026 Jun 23;24(1):370. PMID: 42337564 -
Cell Commun Signal
Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]2024 Jan 18;22(1):53. PMID: 38238728 -
J Neuroinflammation
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss. [Abstract]2024 Nov 14;21(1):295. PMID: 39543619 -
Hemasphere
CEBP and ZEB2 alterations define three distinct subtypes of B-cell acute lymphoblastic leukemia. [Abstract]2026 Jun 15;10(6):e70383. PMID: 42306066 -
Phytomedicine
Cyasterone regulates lipid metabolism and autophagy mediated by the AMPK signaling pathway to improve KOA synovitis. [Abstract]2026 Apr:153:157937. PMID: 41687535 -
Phytomedicine
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis. [Abstract]2025 Oct 13:148:157385. PMID: 41086673 -
Phytomedicine
Wogonin improves colitis by activating the AhR pathway to regulate the plasticity of ILC3/ILC1. [Abstract]2024 Jun:128:155425. PMID: 38518634 -
Adv Healthc Mater
pH-Responsive Probiotic-Liposome Hybrid System Synergistically Treats Radiation-Induced Injury via Dual Mechanisms of Anti-Inflammatory and Microbiome Modulation. [Abstract]2025 Jun 5:e2501642. PMID: 40474448 -
Clin Cancer Res
Ibrutinib and PD-1 blockade potentiate mesothelin-targeting CAR-T cell therapy in preclinical models of pancreatic cancer. [Abstract]2025 Nov 13. PMID: 41231131 -
Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253 -
Cell Death Discov
Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma. [Abstract]2025 Oct 6;11(1):445. PMID: 41053160 -
Acta Pharmacol Sin
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity. [Abstract]2025 Aug 19. PMID: 40830678 -
Environ Int
Combined effects of ozone and heat on intestinal barrier integrity and epithelial renewal: mediating roles of gut microbiota and tryptophan metabolism. [Abstract]2026 Feb:208:110128. PMID: 41687337 -
Proc Natl Acad Sci U S A
Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread. [Abstract]2026 Jun 16;123(24):e2536989123. PMID: 42268890 -
Proc Natl Acad Sci U S A
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids. [Abstract]2022 Oct 11;119(41):e2203480119. PMID: 36197994 -
Apoptosis
Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer. [Abstract]2026 Apr 29;31(5):132. PMID: 42050204 -
Apoptosis
2026 Jan 10;31(1):30. PMID: 41518439 -
Cell Chem Biol
Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity. [Abstract]2025 Jul 17;32(7):926-941.e23. PMID: 40628257 -
Alzheimers Res Ther
Pathway-based network medicine identifies novel natural products for Alzheimer's disease. [Abstract]2025 Feb 14;17(1):43. PMID: 39953559 -
Int J Biol Macromol
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Cells
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Pharmaceuticals (Basel)
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Int Immunopharmacol
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Front Pharmacol
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Biochim Biophys Acta Mol Basis Dis
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Mediators Inflamm
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Sci Rep
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bioRxiv
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bioRxiv
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Biomed Pharmacother
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Biomed Pharmacother
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Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (333.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (333.33 mM)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
View the Complete Stock Solution Preparation Table
Preparing Stock Solutions
View the Complete Stock Solution Preparation Table
Concentration
Solvent
Mass
1 mg
5 mg
10 mg
Concentration
Solvent
Mass
1 mM
3.3333 mL
16.6667 mL
33.3333 mL
5 mM
0.6667 mL
3.3333 mL
6.6667 mL
10 mM
0.3333 mL
1.6667 mL
3.3333 mL
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Molarity Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Dilution Calculator
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
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Handling Instructions (2659 KB)
References
[2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12. [Content Brief]
[3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21. [Content Brief]
[4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61. [Content Brief]
[5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20. [Content Brief]
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Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.3333 mL | 16.6667 mL | 33.3333 mL | 83.3333 mL |
| 5 mM | 0.6667 mL | 3.3333 mL | 6.6667 mL | 16.6667 mL | |
| 10 mM | 0.3333 mL | 1.6667 mL | 3.3333 mL | 8.3333 mL | |
| 15 mM | 0.2222 mL | 1.1111 mL | 2.2222 mL | 5.5556 mL | |
| 20 mM | 0.1667 mL | 0.8333 mL | 1.6667 mL | 4.1667 mL | |
| 25 mM | 0.1333 mL | 0.6667 mL | 1.3333 mL | 3.3333 mL | |
| 30 mM | 0.1111 mL | 0.5556 mL | 1.1111 mL | 2.7778 mL | |
| 40 mM | 0.0833 mL | 0.4167 mL | 0.8333 mL | 2.0833 mL | |
| 50 mM | 0.0667 mL | 0.3333 mL | 0.6667 mL | 1.6667 mL | |
| 60 mM | 0.0556 mL | 0.2778 mL | 0.5556 mL | 1.3889 mL | |
| 80 mM | 0.0417 mL | 0.2083 mL | 0.4167 mL | 1.0417 mL | |
| 100 mM | 0.0333 mL | 0.1667 mL | 0.3333 mL | 0.8333 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PEG300 Related Classifications
HY-Y0873 Related Classifications
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