country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187648

Copy Link Print Information

pNPPT cyclohexanamine

Name: pNPPT cyclohexanamine
Brand: MedChemExpress
SKU: HY-187648
Availability: PreOrder

(Synonyms: p-Nitrophenyl phosphorothioate cyclohexanamine)

pNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.

For research use only. We do not sell to patients.

CAS No.: 167698-72-8
Formula: C₁₈H₃₂N₃O₅PS
Molecular Weight:433.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

pNPPT cyclohexanamine Chemical Structure

CAS No.: 167698-72-8

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

pNPPT (compound 2a) cyclohexanamine is efficiently hydrolyzed by wild-type PP1γ, with a maximum catalytic efficiency of 31 M^-1s^-1 and a second-order rate acceleration ratio of 1.7 × 10¹¹. The transition state is characterized by restricted leaving group bond cleavage and effective general acid neutralization of the leaving group. The hydrolysis catalytic efficiency decreases for the PP1 R96K and PP1 R221K single mutants of PP1γ, with corresponding catalytic efficiency values of 0.8 M^-1s^-1 and 1.9 M^-1s^-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 167698-72-8
Molecular Weight 433.50
Formula C₁₈H₃₂N₃O₅PS
SMILES

O=P(O)(S)OC(C=C1)=CC=C1[N+]([O-])=O.NC2CCCCC2.NC3CCCCC3
Synonyms

p-Nitrophenyl phosphorothioate cyclohexanamine
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chu Y, et al. Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. Biochemistry, 2017, 56(30): 3923-3933.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote