AMCA
Based on 1 Customer Validation
AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17 (HY-170405).
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- Pureté: 99.58%
- CAS No.: 701-54-2
- Formule: C8H15NO2
- Masse moléculaire:157.21
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform PROTAC Linkers
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-3899353050
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 701-54-2
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Appearance Solid
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Masse moléculaire 157.21
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Formule C8H15NO2
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Color White to light brown
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SMILES
O=C(C1CCC(CN)CC1)O
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Synonyms
4-(Aminomethyl)-1-cyclohexanecarboxylic acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
H2O : 87.5 mg/mL (556.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.3609 mL | 31.8046 mL | 63.6092 mL | 159.0230 mL |
| 5 mM | 1.2722 mL | 6.3609 mL | 12.7218 mL | 31.8046 mL | |
| 10 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL | 15.9023 mL | |
| 15 mM | 0.4241 mL | 2.1203 mL | 4.2406 mL | 10.6015 mL | |
| 20 mM | 0.3180 mL | 1.5902 mL | 3.1805 mL | 7.9511 mL | |
| 25 mM | 0.2544 mL | 1.2722 mL | 2.5444 mL | 6.3609 mL | |
| 30 mM | 0.2120 mL | 1.0602 mL | 2.1203 mL | 5.3008 mL | |
| 40 mM | 0.1590 mL | 0.7951 mL | 1.5902 mL | 3.9756 mL | |
| 50 mM | 0.1272 mL | 0.6361 mL | 1.2722 mL | 3.1805 mL | |
| 60 mM | 0.1060 mL | 0.5301 mL | 1.0602 mL | 2.6504 mL | |
| 80 mM | 0.0795 mL | 0.3976 mL | 0.7951 mL | 1.9878 mL | |
| 100 mM | 0.0636 mL | 0.3180 mL | 0.6361 mL | 1.5902 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AMCA Related Classifications
HY-A0102 Related Classifications
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