Avenanthramide-C methyl ester
Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity.
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- CAS No.: 955382-52-2
- Formule: C17H15NO6
- Masse moléculaire:329.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Avenanthramide-C methyl ester dose-dependently reduces mRNA expression and secretion of IL-6, IL-8, and MCP-1[1].
Inhibits IL-1β and TNFα-stimulated NF-κB activation[1].
Inhibits NFκB-dependent reporter gene expression activated by TNFR-associated factors 2 and 6 (TRAF2, TRAF6) and NFκB-inducing kinase (NIK)[1].
Avenanthramide-C methyl ester also dose-dependently reduces the phosphorylation levels of IκB kinase (IKK) and IκB and prevents IκB degradation as measured by Western blotting[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WB HAEC and HUVEC cells
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Concentration:1, 10, 40, and 100 μM
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Incubation Time:24 h
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Result:Inhibited NF-κB p50 and p65 DNA binding activity of nuclear.
Suppresseed IL-1β-stimulated secretion of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
Inhibited the phosphorylation of IKKα/IKKβ and IκB and degradation of IκB induced by IL-1β.
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Cell Line:WB HAEC and HUVEC cells
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Concentration:40, and 100 μM
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Incubation Time:24 h
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Result:Suppressed IL-1β-stimulated mRNA expression of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
Chemical Information
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CAS No. 955382-52-2
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Masse moléculaire 329.30
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Formule C17H15NO6
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SMILES
COC(C1=C(C=CC(O)=C1)NC(/C=C/C2=CC(O)=C(C=C2)O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avenanthramide-C methyl ester Related Classifications
HY-138284 Related Classifications
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