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Cat. No.: HY-116473

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CFM-1

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells.

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CAS No.: 1380448-60-1
Formule: C₁₂H₇BrN₂O₂S₂
Masse moléculaire:355.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CFM-1 Chemical Structure

CAS No.: 1380448-60-1

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Daoy	IC₅₀	8.12 μg/mL Compound: CFM-1	Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
HeLa	IC₅₀	13.5 μg/mL Compound: CFM-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
Huh-7	IC₅₀	8.18 μg/mL Compound: CFM-1	Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
MDA-MB-231	IC₅₀	19.7 μg/mL Compound: CFM-1	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]

Chemical Information

CAS No. 1380448-60-1
Masse moléculaire 355.23
Formule C₁₂H₇BrN₂O₂S₂
SMILES

O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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