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Cat. No.: HY-181829

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Ctx-L3

Ctx-L3 is a selective EGFR PTAC (PSMA-targeted chimera) degrader (DC₅₀: 4.3 pM in LNCaP cells) and LYTAC. Ctx-L3 recruits prostate-specific membrane antigen (PSMA) and mediates lysosomal degradation of EGFR in PSMA-positive prostate cancer cells. Ctx-L3 exhibits degrading activity against EGFR in prostate cancer cells. Ctx-L3 is applicable to related research on prostate cancer.

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Formule: C₇₂H₁₁₄N₁₀O₂₇
Masse moléculaire:1551.73

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ctx-L3 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

Ctx-L3 (0.01-100 nM; 24 h) potently and selectively induces lysosomal degradation of EGFR in PSMA-positive prostate cancer cell lines, with a DC₅₀ of 4.3 pM in LNCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1551.73
Formule C₇₂H₁₁₄N₁₀O₂₇
SMILES

O=C(CCC(NCCOCCOCCOCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)N(C1=C2C=CC=C1)CC(C=CC=C3)=C3C4=C2N=NN4CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cai D, et al. Development of Prostate-Specific Lysosome-Targeting Degraders. J Am Chem Soc. 2026;148(7):7171-7180. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références

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Ctx-L3

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Ctx-L3 Related Classifications

HY-181829 Related Classifications