GAP-1173149
GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1622645-58-2
- Formule: C14H19N5O3
- Masse moléculaire:305.33
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
GAP-1173149 shows EC50 values of 15.6, 18.6, 5.3 and 11.62 μM in U-2 OS cells, Vero cells, CHIKV replicon and normal human dermal fibroblasts[1].
GAP-1173149 shows CC50 values >100 μM in U-2 OS and Vero cells, and >500 μM in normal human dermal fibroblasts[1].
GAP-1173149 (100 μM) exhibits alphavirus-specific activity, inhibiting RNA replication of CHIKV, o’nyong-nyong virus (ONNV), Ross River virus (RRV), Eastern equine encephalitis virus (EEEV) and Barmah Forest virus (BFV), while showing no inhibition on unrelated viruses (HPIV3, RSV, SARS-CoV-2, VSV) or Sindbis virus (SINV)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1622645-58-2
-
Masse moléculaire 305.33
-
Formule C14H19N5O3
-
SMILES
O=C(NCC1=NNC2=C1CCCCC2)CN(C(NC3)=O)C3=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GAP-1173149 Related Classifications
HY-178334 Related Classifications
Powered by Bioz