NP-313
Based on 1 Customer Validation
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow.
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- Pureté: 99.31%
- CAS No.: 5397-78-4
- Formule: C12H8ClNO3
- Masse moléculaire:249.65
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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High-Throughput Bioactive Compound Library
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
1.7 μM
Compound: 5
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Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
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[PMID: 19101151] |
| SK-BR-3 | IC50 |
0.6 μM
Compound: 5
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Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
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[PMID: 19101151] |
| SK-BR-3 | IC50 |
6.6 μM
Compound: 5
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Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
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[PMID: 19101151] |
NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner. The maximum inhibition of platelet aggregation induced by thrombin and A23187 was approximately 80% and 60%, respectively[1].
NP-313 (0-8 μM) concentration-dependently inhibited P-selectin expression and thromboxane B 2 (TXB2) production in human platelets induced by collagen or thrombin. Also, NP-313 inhibited COX-1 and TXA 2 synthase with the IC 50 values of 1.5 and 3.9 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5397-78-4
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Appearance Solid
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Masse moléculaire 249.65
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Formule C12H8ClNO3
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Color Light yellow to yellow
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SMILES
CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (100.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0056 mL | 20.0280 mL | 40.0561 mL | 100.1402 mL |
| 5 mM | 0.8011 mL | 4.0056 mL | 8.0112 mL | 20.0280 mL | |
| 10 mM | 0.4006 mL | 2.0028 mL | 4.0056 mL | 10.0140 mL | |
| 15 mM | 0.2670 mL | 1.3352 mL | 2.6704 mL | 6.6760 mL | |
| 20 mM | 0.2003 mL | 1.0014 mL | 2.0028 mL | 5.0070 mL | |
| 25 mM | 0.1602 mL | 0.8011 mL | 1.6022 mL | 4.0056 mL | |
| 30 mM | 0.1335 mL | 0.6676 mL | 1.3352 mL | 3.3380 mL | |
| 40 mM | 0.1001 mL | 0.5007 mL | 1.0014 mL | 2.5035 mL | |
| 50 mM | 0.0801 mL | 0.4006 mL | 0.8011 mL | 2.0028 mL | |
| 60 mM | 0.0668 mL | 0.3338 mL | 0.6676 mL | 1.6690 mL | |
| 80 mM | 0.0501 mL | 0.2504 mL | 0.5007 mL | 1.2518 mL | |
| 100 mM | 0.0401 mL | 0.2003 mL | 0.4006 mL | 1.0014 mL |
NP-313 Related Classifications
HY-129496 Related Classifications
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