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Cat. No.: HY-P11944

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Peptide 22

Peptide 22 is a polypeptide that binds to EGFR. Peptide 22 competes with endogenous EGF for EGFR binding sites and is taken up by triple-negative breast cancer cells in a dose-dependent manner. Peptide 22 can be used in studies related to triple-negative breast cancer.

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CAS No.: 3030200-17-7
Formule: C₇₅H₉₆N₁₆O₂₀
Masse moléculaire:1541.66

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Please store the product under the recommended conditions in the Certificate of Analysis.

Peptide 22 Chemical Structure

CAS No.: 3030200-17-7

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
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- In Vitro
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Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

Peptide 22 (YHWYGYTPENVI) (2 μM) specifically binds to EGFR on MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells, with significantly higher uptake than the parent GE11 peptide and dose-dependent binding saturation at 2 μM in MDA-MB-231 cells^[1].
Peptide 22 shows high uptake in MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells but has low serum stability, requiring cyclization to enhance in vivo utility^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3030200-17-7
Masse moléculaire 1541.66
Formule C₇₅H₉₆N₁₆O₂₀
SMILES

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H]([C@H](O)C)C(N6[C@@H](CCC6)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC7=CC=C(C=C7)O)N
Sequence

Tyr-His-Trp-Tyr-Gly-Tyr-Thr-Pro-Glu-Asn-Val-Ile
Sequence Shortening

YHWYGYTPENVI
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nag A, et al. Fluorescent Sensors of Phosphate Containing Biomolecules. Israel Journal of Chemistry. 2020 Dec 09;61(3-4):169-184.

[2]. Nisticò N, et al. Development of Cyclic Peptides Targeting the Epidermal Growth Factor Receptor in Mesenchymal Triple-Negative Breast Cancer Subtype. Cells. 2023 Apr 03;12(7):1078.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Peptide 22

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Peptide 22 Related Classifications

HY-P11944 Related Classifications