S21-1011
S21-1011 is a selective inhibitor for butyrylcholinesterase (BChE), with IC50 of 0.059 and 0.162 μM, for eqBChE and hBChE, respectively. S21-1011 exhibits good blood-brain barrier (BBB) permeability and good pharmacokinetic characters. S21-1011 exhibits anti-inflammatory activity through activation of keap1-Nrf2-ARE pathway (EC50 is 23.48 μM for antioxidant element ARE activation), ameliorates cognitive impairment in murine Alzheimer’s disease model.
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- CAS No.: 2671859-87-1
- Formule: C30H32N4O
- Masse moléculaire:464.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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eqBCHE 0.059 μM (IC50) |
hBCHE 0.162 μM (IC50) |
Chemical Information
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CAS No. 2671859-87-1
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Masse moléculaire 464.60
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Formule C30H32N4O
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SMILES
CCCC1=CC=C(C(NC2=CN=C(C=CC=C3)C3=C2N4CCN(CC5=CC=CC=C5)CC4)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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