SPHINX
Based on 1 Customer Validation
SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.87%
- CAS No.: 848057-98-7
- Formule: C17H17F3N2O3
- Masse moléculaire:354.32
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.58 μM (SRPK1)[1]
SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2[1]. SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ARPE-19 cell line
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Concentration:10 μM
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Incubation Time:2 hours
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Result:Blocked EGF-induced phosphorylation of SRSF1 and SRSF2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/B6 mice with laser-induced CNV[1]
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Dosage:10 ng
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Administration:Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
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Result:Significantly reduced neovascular growth compared with saline-injected controls.
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Animal Model:Norway Brown rats with laser-induced choroidal neovascularization[1]
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Dosage:25 ng (10 ng/uL)
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Administration:Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
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Result:Significantly reduced the CNV area compared with saline injected controls.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 848057-98-7
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Appearance Solid
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Masse moléculaire 354.32
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Formule C17H17F3N2O3
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(C)O1)NC2=CC(C(F)(F)F)=CC=C2N3CCOCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (141.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8223 mL | 14.1115 mL | 28.2231 mL | 70.5577 mL |
| 5 mM | 0.5645 mL | 2.8223 mL | 5.6446 mL | 14.1115 mL | |
| 10 mM | 0.2822 mL | 1.4112 mL | 2.8223 mL | 7.0558 mL | |
| 15 mM | 0.1882 mL | 0.9408 mL | 1.8815 mL | 4.7038 mL | |
| 20 mM | 0.1411 mL | 0.7056 mL | 1.4112 mL | 3.5279 mL | |
| 25 mM | 0.1129 mL | 0.5645 mL | 1.1289 mL | 2.8223 mL | |
| 30 mM | 0.0941 mL | 0.4704 mL | 0.9408 mL | 2.3519 mL | |
| 40 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7639 mL | |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5645 mL | 1.4112 mL | |
| 60 mM | 0.0470 mL | 0.2352 mL | 0.4704 mL | 1.1760 mL | |
| 80 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8820 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7056 mL |
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