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Cat. No.: HY-189815

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TR79

TR79 is a mitochondrial ClpP protease activator with an EC₅₀ of 414.49 nM. TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation. TR79 can be used in research on mitochondria-related diseases (such as cancer and neurodegenerative diseases) and mitochondrial metabolic abnormalities.

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CAS No.: 2365073-59-0
Formule: C₂₆H₂₆F₃N₅O₂
Masse moléculaire:497.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

TR79 Chemical Structure

CAS No.: 2365073-59-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

Mitochondrial Function

TR79 is a potent ClpP agonist, with an EC₅₀ of 414.49 nM in the ClpP activation assay^[1].
TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation in cultured cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2365073-59-0
Masse moléculaire 497.51
Formule C₂₆H₂₆F₃N₅O₂
SMILES

NCCCN(C1=C(CN(CC2=CC=CC(C#N)=C2)CC1)C(N3CC4=CC=C(C(F)(F)F)C=C4)=O)C3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chen C, et al. Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond. JACS Au. 2026 Sep 28;6(9):5439-5454. [Content Brief]

[2]. Yamada W, et al. Targeted protein degradation in the mitochondrial matrix and its application to chemical control of mitochondrial morphology. Chem Sci. 2024 Aug 28;15(36):14625-14634. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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