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Cat. No.: HY-134648

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Ganfeborole

(Synonyms: GSK656 free base; GSK3036656 free base; GSK070 free base)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis.

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CAS No.: 2131798-12-2
Formule: C₁₀H₁₃BClNO₄
Masse moléculaire:257.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Ganfeborole Chemical Structure

CAS No.: 2131798-12-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 2131798-12-2
Masse moléculaire 257.48
Formule C₁₀H₁₃BClNO₄
SMILES

OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21
Synonyms

GSK656 free base; GSK3036656 free base; GSK070 free base
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Nat Nanotechnol

Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics. [Abstract]

2025 Oct;20(10):1502-1513. PMID: 40931056
Antimicrob Agents Chemother

A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo. [Abstract]

2022 Sep 20;66(9):e0060122. PMID: 35969055
Biofuel Bioprod Bior

2025 Sep 3;19(5):1378-1399.
ACS Chem Biol

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]

2022 Jan 21;17(1):39-53. PMID: 34908399
bioRxiv

2024 May 23.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li X, et, al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Ganfeborole

5 Cited Publications

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Pureté et documentation
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Ganfeborole

Publications Citing Use of MedChemExpress (MCE) Ganfeborole

Activité biologique

Chemical Information

Publications (5)

Pureté et documentation

Références

Calculators

Help & FAQs

Ganfeborole Related Classifications

HY-134648 Related Classifications