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Cat. No.: HY-181829

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Ctx-L3

Ctx-L3 is a selective EGFR PTAC (PSMA-targeted chimera) degrader (DC₅₀: 4.3 pM in LNCaP cells) and LYTAC. Ctx-L3 recruits prostate-specific membrane antigen (PSMA) and mediates lysosomal degradation of EGFR in PSMA-positive prostate cancer cells. Ctx-L3 exhibits degrading activity against EGFR in prostate cancer cells. Ctx-L3 is applicable to related research on prostate cancer.

For research use only. We do not sell to patients.

Formula: C₇₂H₁₁₄N₁₀O₂₇
Molecular Weight:1551.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ctx-L3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All EGFR Isoforms :

In Vitro

Ctx-L3 (0.01-100 nM; 24 h) potently and selectively induces lysosomal degradation of EGFR in PSMA-positive prostate cancer cell lines, with a DC₅₀ of 4.3 pM in LNCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1551.73
Formula C₇₂H₁₁₄N₁₀O₂₇
SMILES

O=C(CCC(NCCOCCOCCOCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)N(C1=C2C=CC=C1)CC(C=CC=C3)=C3C4=C2N=NN4CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cai D, et al. Development of Prostate-Specific Lysosome-Targeting Degraders. J Am Chem Soc. 2026;148(7):7171-7180. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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