CD81 - CD81 molecule Gene

Also Known as S5.7; CVID6; TAPA1; TSPAN28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 975

About CD81

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:2,376,180-2,397,397 (from NCBI)

This gene has 17 transcripts (splice variants), 266 orthologues, 32 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 241.8), fat (RPKM 237.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

CD81 Products (2)

mRNA	Protein	Name
NM_001297649.2	NP_001284578.1	CD81 antigen isoform 2
NM_004356.4	NP_004347.1	CD81 antigen isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MHC class II protein binding	IDA IDA: Inferred from direct assay	8409388	GOA
enables cholesterol binding	IDA IDA: Inferred from direct assay	27881302	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	12796480	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2398277	GOA
enables transferrin receptor binding	IPI IPI: Inferred from physical interaction	25635054	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	20375010	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD4-positive, alpha-beta T cell costimulation	IDA IDA: Inferred from direct assay	22307619	GOA
involved in humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	20237408	GOA
involved in immunological synapse formation	IMP IMP: Inferred from mutant phenotype	23858057	GOA
involved in macrophage fusion	IDA IDA: Inferred from direct assay	12796480	GOA
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	10400713	GOA
involved in positive regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20237408	GOA
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	22307619	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	14676841	GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	8766544	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23858057	GOA
involved in positive regulation of T-helper 2 cell cytokine production	IDA IDA: Inferred from direct assay	8766544	GOA
involved in positive regulation of adaptive immune memory response	IMP IMP: Inferred from mutant phenotype	20237408	GOA
involved in positive regulation of protein catabolic process in the vacuole	IMP IMP: Inferred from mutant phenotype	25635054	GOA
involved in positive regulation of protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	16449649	GOA
involved in positive regulation of receptor clustering	IDA IDA: Inferred from direct assay	23858057	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	25635054	GOA
involved in protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	25635054	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	14676841	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20237408	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	25635054	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20375010	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15908444	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	21930792	GOA
located in membrane	IDA IDA: Inferred from direct assay	27881302	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8409388	GOA
located in tetraspanin-enriched microdomain	IDA IDA: Inferred from direct assay	28871089	GOA
located in vesicle	IDA IDA: Inferred from direct assay	9360996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD81 Protein Structure

Tetraspannin

0
100
200
236 a.a.

Protein Preferred Names	Protein Names
CD81 antigen	26 kDa cell surface protein TAPA-1

CD81 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD81	P60033	MCEE	Homo sapiens	Q96PE7	Validated Y2H	32296183
Intra	CD81	P60033	MCEE	Homo sapiens	Q96PE7	Y2H Array	32296183
Intra	CD81	P60033	MCEE	Homo sapiens	Q96PE7	Y2H Prey Pooling	32296183
Intra	CD81	P60033	LBR	Homo sapiens	Q14739	Validated Y2H	32296183
Intra	CD81	P60033	LBR	Homo sapiens	Q14739	Y2H Array	32296183
Intra	CD81	P60033	LBR	Homo sapiens	Q14739	Y2H Prey Pooling	32296183
Intra	CD81	P60033	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	CD81	P60033	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	CD81	P60033	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CD81	P60033	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CD81	P60033	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CD81	P60033	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Prey Pooling	32296183
Intra	CD81	P60033	SLC26A6	Homo sapiens	Q9BXS9-3	Validated Y2H	32296183
Intra	CD81	P60033	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Array	32296183
Intra	CD81	P60033	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CD81	P60033	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	CD81	P60033	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CD81	P60033	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	CD81	P60033	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CD81	P60033	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CD81	P60033	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	23091066
Intra	CD81	P60033	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	32900848
Intra	CD81	P60033	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	19587294
Intra	CD81	P60033	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	CD81	P60033	SDHAF4	Homo sapiens	Q5VUM1	Validated Y2H	32296183
Intra	CD81	P60033	SDHAF4	Homo sapiens	Q5VUM1	Y2H Array	32296183
Intra	CD81	P60033	SDHAF4	Homo sapiens	Q5VUM1	Y2H Prey Pooling	32296183
Intra	CD81	P60033	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	CD81	P60033	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	CD81	P60033	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	CD81	P60033	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CD81	P60033	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	CD81	P60033	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CD81	P60033	O14672-PRO_0000029067	Homo sapiens	O14672-PRO_0000029067	Anti Tag CoIP	19587294
Intra	CD81	P60033	BST2	Homo sapiens	Q10589	Validated Y2H	32296183
Intra	CD81	P60033	BST2	Homo sapiens	Q10589	Y2H Prey Pooling	32296183
Intra	CD81	P60033	BST2	Homo sapiens	Q10589	Y2H Array	32296183
Intra	CD81	P60033	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	CD81	P60033	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	CD81	P60033	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	CD81	P60033	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	CD81	P60033	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	CD81	P60033	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	CD81	P60033	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	CD81	P60033	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	CD81	P60033	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	CD81	P60033	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	CD81	P60033	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	CD81	P60033	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	CD81	P60033	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	CD81	P60033	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	CD81	P60033	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	CD81	P60033	GJA4	Homo sapiens	P35212	Y2H Prey Pooling	32296183
Intra	CD81	P60033	GJA4	Homo sapiens	P35212	Y2H Array	32296183
Intra	CD81	P60033	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	CD81	P60033	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	CD81	P60033	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	CD81	P60033	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	CD81	P60033	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	CD81	P60033	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	CD81	P60033	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	CD81	P60033	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	CD81	P60033	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	CD81	P60033	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	CD81	P60033	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	CD81	P60033	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	CD81	P60033	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CD81	P60033	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	CD81	P60033	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CD81	P60033	SCARB1	Homo sapiens	Q8WTV0	Anti Bait CoIP	30024968
Cross	CD81	P60033	Q99IB8-PRO_0000045596	Hepatitis C virus	Q99IB8-PRO_0000045596	Pull Down	19088272
Cross	CD81	P60033	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	FACS	10400713
Cross	CD81	P60033	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	Far-WB	9794763
Cross	CD81	P60033	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	Far-WB	12522210

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD81 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72126	CD81 Protein, Human (His-SUMO)	P60033 (F113-K201)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72706	CD81 Protein, Human (HEK293, Fc)	P60033 (F113-K201)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74264	CD81 Protein, Human (HEK293, His)	P60033 (F113-K201)	≥ 90%, as determined by reducing SDS-PAGE.

CD81 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80608	CD81 Antibody (YA525)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
HY-P80608A	CD81 Antibody (YA525)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
HY-P84416	CD81 Antibody (YA4113)	WB, IHC-P, FC, ELISA	Human, Rat
HY-P84416A	CD81 Antibody (YA4113)(PBS only)	WB, IHC-P, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 6	CVID6 Antibody Deficiency Due To Cd81 Defect Common Variable Immunodeficiency 6 Immunodeficiency, Variable, Common, Type 6
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Cryoglobulinemia	Cryoimmunoglobulinaemia
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142989	1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine		≥98.0%	Unkown
HY-RS17125	Cd81 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3320	APC-AF700		/	Unkown
HY-RS02270	CD81 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N2940	Bisandrographolide A	Activator	/	Unkown
HY-RS23570	Cd81 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991200	OM-7D3-B3		97.98%	Unkown
HY-P991933	Anti-CD81 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD81	VGNC	VGNC:70780
Bos taurus	CD81	VGNC	VGNC:50034
Mus musculus	CD81	MGD	MGI:1096398
Rattus norvegicus	CD81	RGD	RGD:2315
Felis catus	CD81	VGNC	VGNC:60640
Canis familiaris	CD81	VGNC	VGNC:49705
Others	CD81	NCBI