pDI
Based on 1 Customer Validation
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC50s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 99.63%
- CAS No.: 1443628-44-1
- Formula: C71H99N17O19
- Molecular Weight:1494.65
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 10 nM (MDM2-p53); 100 nM (MDMX-p53)[2]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1443628-44-1
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Appearance Solid
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Molecular Weight 1494.65
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Formula C71H99N17O19
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Color White to off-white
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Sequence
Leu-Thr-Phe-Glu-His-Tyr-Trp-Ala-Gln-Leu-Thr-Ser-NH2
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Sequence Shortening
LTFEHYWAQLTS-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (66.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67(19):17893-17904. [Content Brief]
[2]. Hu B, et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6691 mL | 3.3453 mL | 6.6905 mL | 16.7263 mL |
| 5 mM | 0.1338 mL | 0.6691 mL | 1.3381 mL | 3.3453 mL | |
| 10 mM | 0.0669 mL | 0.3345 mL | 0.6691 mL | 1.6726 mL | |
| 15 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1151 mL | |
| 20 mM | 0.0335 mL | 0.1673 mL | 0.3345 mL | 0.8363 mL | |
| 25 mM | 0.0268 mL | 0.1338 mL | 0.2676 mL | 0.6691 mL | |
| 30 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5575 mL | |
| 40 mM | 0.0167 mL | 0.0836 mL | 0.1673 mL | 0.4182 mL | |
| 50 mM | 0.0134 mL | 0.0669 mL | 0.1338 mL | 0.3345 mL | |
| 60 mM | 0.0112 mL | 0.0558 mL | 0.1115 mL | 0.2788 mL |
pDI Related Classifications
HY-P11256 Related Classifications
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