Referencia número: HY-100579

Biologically Validated

Ferrostatin-1

Name: Ferrostatin-1
Brand: MedChemExpress
SKU: HY-100579
Price: 72.00 USD
Availability: InStock
Rating: 5 (1778 reviews)

(Synonyms: Fer-1)

1778 Cited Publications

Revisión del cliente

Based on 1778 publication(s) in Google Scholar

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 99.71%
No. CAS: 347174-05-4
Fòrmula: C₁₅H₂₂N₂O₂
Peso molecular:262.35

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Ferrostatin-1 Chemical Structure

No. CAS: 347174-05-4

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Precio

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- MCE Validation Data
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1778)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

EC50: 60 nM (Ferroptosis)^[1]

MCE Validation Data

HT-1080 cells were seeded at 8000 cells/well in a 96 well plate and were cultured overnight. Cells were treated with 40 nM RSL-3 (HY-100218A) or 200 nM Erastin (HY-15763) in the presence or absence of Ferrostatin-1 (HY-100579) (Fer-1, 0.5 μM) for 24 h. Cell viability was assayed by CCK-8 kit (HY-K0301). The results indicated that Fer-1 inhibited the ferroptosis induced by RSL3 or Erastin.

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	EC₅₀	253 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3 induced ferroptosis in human 786-0 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity against RSL3 induced ferroptosis in human 786-0 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
AML12	EC₅₀	0.104 μM Compound: Fer-1	Protection against CCl4-induced ferroptosis in mouse AML12 cells assessed as cell viability Protection against CCl4-induced ferroptosis in mouse AML12 cells assessed as cell viability	[PMID: 39047113]
BJ	EC₅₀	38.2 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3 induced ferroptosis in human BJ cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity against RSL3 induced ferroptosis in human BJ cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
Fibroblast	EC₅₀	33 nM Compound: Fer-1	Inhibition of erastin-induced cell death in FRDA patient-derived fibroblast assessed as depletion of cellular ATP incubated for 12 hrs followed by erastin stimulation and measured after by luciferase-linked ATPase enzymatic assay Inhibition of erastin-induced cell death in FRDA patient-derived fibroblast assessed as depletion of cellular ATP incubated for 12 hrs followed by erastin stimulation and measured after by luciferase-linked ATPase enzymatic assay	[PMID: 33214825]
H9c2	EC₅₀	68.6 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3 induced ferroptosis in rat H9c2 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity against RSL3 induced ferroptosis in rat H9c2 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
HEK-293T	EC₅₀	5.69 μM Compound: Fer-1	Protection against cisplatin-induced cytotoxicity in HEK293T cells assessed as cell viability measured after 24 to 48 hrs by MTT assay Protection against cisplatin-induced cytotoxicity in HEK293T cells assessed as cell viability measured after 24 to 48 hrs by MTT assay	[PMID: 37976709]
HT-1080	EC₅₀	0.07 μM Compound: Fer-1	Anti-ferroptotic activity against Erastin-induced ferroptosis in human HT-1080 cells assessed as cell activity measured after 24 hrs by Cell Titer-Glo luminescent assay Anti-ferroptotic activity against Erastin-induced ferroptosis in human HT-1080 cells assessed as cell activity measured after 24 hrs by Cell Titer-Glo luminescent assay	[PMID: 35300093]
HT-1080	EC₅₀	0.088 μM Compound: Fer-1	Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
HT-1080	EC₅₀	137.9 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-1080 cells assessed as inhibition of ferroptosis incubated for 24 hrs by CCK-8 assay Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-1080 cells assessed as inhibition of ferroptosis incubated for 24 hrs by CCK-8 assay	[PMID: 38056303]
HT-1080	EC₅₀	203.4 nM Compound: Fer-1	Inhibition of RSL3-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK8 assay Inhibition of RSL3-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38822802]
HT-1080	EC₅₀	23.4 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3 induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity against RSL3 induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
HT-1080	EC₅₀	23.4 nM Compound: Fer-1	Anti-ferroptotic activity in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
HT-1080	EC₅₀	75.2 nM Compound: Fer-1	Anti-ferroptotic activity against imidazole ketone erastin (IKE) induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay Anti-ferroptotic activity against imidazole ketone erastin (IKE) induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay	[PMID: 37950965]
HT-1080	IC₅₀	60 nM Compound: Fer-1	Anti-ferroptotic activity against Erastin-induced human HT-1080 cells assessed as inhibition of ferroptosis incubated for 72 hrs by CCK-8 assay Anti-ferroptotic activity against Erastin-induced human HT-1080 cells assessed as inhibition of ferroptosis incubated for 72 hrs by CCK-8 assay	[PMID: 38996382]
HT-1080	IC₅₀	95 nM Compound: 1; fer-1	Antiferroptotic activity in human HT1080 cells assessed as inhibition of erastin-induced cell death by Alamar blue assay Antiferroptotic activity in human HT1080 cells assessed as inhibition of erastin-induced cell death by Alamar blue assay	[PMID: 26696014]
HT-1080	IC₅₀	95 nM Compound: 36; Fer-1	Inhibition of erastin-induced cell death in human HT-1080 cells Inhibition of erastin-induced cell death in human HT-1080 cells	[PMID: 36543035]
HT-22	EC₅₀	0.191 μM Compound: Fer-1	Anti-ferroptotic activity in erastin-induced ferroptosis in mouse HT-22 cells assessed as cell viability incubated for 24 hrs by MTT assay Anti-ferroptotic activity in erastin-induced ferroptosis in mouse HT-22 cells assessed as cell viability incubated for 24 hrs by MTT assay	[PMID: 37976709]
HT-22	EC₅₀	81.2 nM Compound: Fer-1	Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-22 cells assessed as cell viability measured after 24 hrs by MTT assay Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-22 cells assessed as cell viability measured after 24 hrs by MTT assay	[PMID: 35796002]
HUVEC	EC₅₀	0.6 μM Compound: Fer-1	Anti-ferroptosis activity in HUVEC cells assessed as inhibition of erastin-induced ferroptosis by measuring lethality suppression incubated for 24 hrs by SRB assay Anti-ferroptosis activity in HUVEC cells assessed as inhibition of erastin-induced ferroptosis by measuring lethality suppression incubated for 24 hrs by SRB assay	[PMID: 38608329]
HUVEC	EC₅₀	0.6 μM Compound: Fer-1	Anti-ferroptotic activity against Erastin-induced ferroptosis in human HUVEC cells assessed as cell viability incubated for 24 hrs by SRB assay Anti-ferroptotic activity against Erastin-induced ferroptosis in human HUVEC cells assessed as cell viability incubated for 24 hrs by SRB assay	[PMID: 38665835]
IMR-32	IC₅₀	18 nM Compound: 1; fer-1	Antiferroptotic activity in human IMR32 neuroblastoma cells assessed as inhibition of erastin-induced cell death preincubated for 1 hr before erastin stimulation and measured after 13 hrs by fluorescence plate reader method Antiferroptotic activity in human IMR32 neuroblastoma cells assessed as inhibition of erastin-induced cell death preincubated for 1 hr before erastin stimulation and measured after 13 hrs by fluorescence plate reader method	[PMID: 26696014]
IMR-32	IC₅₀	33 nM Compound: 1; Fer-1	Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay	[PMID: 30354101]
LLC-MK2	IC₅₀	>240 μM Compound: AA1	Cytotoxicity against monkey LLC-MK2 cells after 96 hrs by Alamar Blue assay Cytotoxicity against monkey LLC-MK2 cells after 96 hrs by Alamar Blue assay	[PMID: 26410073]
Lymphocyte	EC₅₀	48 nM Compound: Fer-1	Anti-ferroptotic activity in FRDA patient-derived Lymphocyte assessed as reduction in RSL3-induced lipid peroxidation incubated for overnight followed by RSL3 stimulation and measured after 90 mins by FACS analysis Anti-ferroptotic activity in FRDA patient-derived Lymphocyte assessed as reduction in RSL3-induced lipid peroxidation incubated for overnight followed by RSL3 stimulation and measured after 90 mins by FACS analysis	[PMID: 33214825]
NIH3T3	IC₅₀	0.22 μM Compound: Fer-1	Inhibition of TBHP-induced ferroptosis in mouse NIH/3T3 cells after 12 hrs by WST-8 assay Inhibition of TBHP-induced ferroptosis in mouse NIH/3T3 cells after 12 hrs by WST-8 assay	[PMID: 31531196]
NIH3T3	IC₅₀	0.27 μM Compound: Fer-1	Inhibition of erastin-induced ferroptosis in mouse NIH/3T3 cells after 24 hrs by WST-8 assay Inhibition of erastin-induced ferroptosis in mouse NIH/3T3 cells after 24 hrs by WST-8 assay	[PMID: 31531196]
RAW264.7	EC₅₀	0.04 μM Compound: Fer-1	Anti-ferroptotic activity against RSL-3 induced ferroptosis in mouse RAW264.7 cells assessed as cell activity measured after 24 hrs by Cell Titer-Glo luminescent assay Anti-ferroptotic activity against RSL-3 induced ferroptosis in mouse RAW264.7 cells assessed as cell activity measured after 24 hrs by Cell Titer-Glo luminescent assay	[PMID: 35300093]

In Vitro

Ferrostatin-1 prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices^[1].
Ferrostatin-1 (2 μM; 24 h) prevents Glutamate (5 mM)-induced neurotoxicity in a rat organotypic hippocampal slice culture (OHSC)^[2].
Ferrostatin-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability^[2].
Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction^[2].
Ferrostatin-1 (1 μM; 6 h) inhibits the oxidative destruction of unsaturated fatty acids in HT-1080 cells, thus increases the number of healthy medium spiny neurons (MSNs)^[3].

Ferroptosis-sensitive Cell Lines

Ferroptosis-sensitive Cells	Ferrostatin-1 Experimental Conditions	Ferroptosis Inducers
HT-1080^[1]	0.5 μM; 24 h; EC₅₀=60 nM	Erastin (10 nM-100 μM; 24 h)
BEAS-2B^[4]	2 μM; 16 h	LPS (10 mg/L; 16 h)
PC12 (differentiated)^[5]	1 μM; 12 h	Erastin (7.5 μM; 12 h)
N27 neuron^[8]	0.004-0.25 μM; 24 h; EC₅₀=0.039 μM	RSL3 (1 μM; 24 h)
BMSCs^[9]	1 μM; 24 h	GSDH (10-50 μM; 24 h)
HT-22^[10]	3-12 μM; 16 h	Glutamate (5 mM; 16 h)
HK‑2^[11]	100 μM; 24 h	Oxalate (2 mM; 24 h)
MLE12^[12]	1 and 5 μM; 24 h	8% and 20% cyclic stretching (CS)
HaCaT^[13]	10 μM	UVB (20mJ/cm²)
Mouse primary astrocytes^[14]	0.1-2 μM; 24 h	Angiotensin II (10 μM; 24 h)
SKOV3^[15]	5 μM; 24 h	Erastin (10 μM; 24 h)
OVCA429^[15]	10 μM; 24 h	Erastin (20 μM; 24 h)
HK-2 WT^[16]	Pretreatment with 2 μM followed by co-treatment with inducers	RSL3 (0.01-1 μM; 8 h)
MDA-MB-468^[16]	Pretreatment with 2 μM for 1 h was performed, followed by co-treatment with the inducer	RSL3 (500 nM; 2 h)
NCI-H1299^[16]	Pretreatment with 2 μM followed by co-treatment with inducers	Erastin (5 μM; 18 h)
HT22 neuron^[17]	Cells were pretreated with the inducer and then co-treated with 10 and 20 μM Ferrostatin-1 for 6, 12, or 24 h	Erastin (0 and 5 μM; 12 h)
HT22 neuron^[18]	Pretreatment with 2 μM for 30 min was performed, followed by co-treatment with the inducer for 24 h	Erastin (1 μM; 24 h)
HT-1080^[19]	0.5 μM; 12 h	Erastin (10 μM; 12 h)
H1975^[20]	Pretreatment with 2 μM for 14 h followed by co-treatment with the inducer for 24 h	RSL3 (1 μM; 6 or 24 h)
A549^[20]	Pretreatment with 2 μM for 14 h followed by co-treatment with the inducer for 24 h	RSL3 (1 μM; 6 or 24 h)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ferrostatin-1 (5 mg/kg; ip; single dose, 30 min before glycerol injection) improves renal function in mice with rhabdomyolysis, whereas no beneficial effects were observed with the pan-caspase inhibitor zVAD or in RIPK3-deficient mice^[1].
Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI)^[4].
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis^[5].
Ferrostatin-1 (10 mg/kg/d, i.p., 3 d) attenuates hypoxic-ischemic brain damage-, oxygen-glucose deprivation-, or Erastin (HY-15763)-induced ferroptosis in brain of neonatal rats^[6].
Ferrostatin-1 (0.655 mg/kg, i.p., 3 times a week for 6 week) exerts anti-ferroptosis effects by increasing GPX4 activity and by inhibiting lipid peroxidation in the salivary gland of ovariectomized (postmenopausal model) rats^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 mice (LPS-induced ALI)^[4]
Dosage:

0.8 mg/kg
Administration:

Tail vein injection
Result:

Exerted therapeutic action against LPS-induced ALI.

Chemical Information

No. CAS 347174-05-4
Appearance Solid
Peso molecular 262.35
Fòrmula C₁₅H₂₂N₂O₂
Color Gray to gray purple
SMILES

O=C(OCC)C1=CC=C(NC2CCCCC2)C(N)=C1
Synonyms

Fer-1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1778)

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Journal Impact Factor

Signal Transduct Target Ther

2026 Jul 29;11(1):309. PMID: 42527413
Signal Transduct Target Ther

Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. [Abstract]

2026 Jan 16;11(1):33. PMID: 41545339
Signal Transduct Target Ther

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin. [Abstract]

2025 Dec 3;10(1):394. PMID: 41330906
Signal Transduct Target Ther

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression. [Abstract]

2025 Dec 26;10(1):420. PMID: 41449244
Signal Transduct Target Ther

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. [Abstract]

2020 May 8;5(1):51. PMID: 32382060

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 May 8;5(1):51. [Abstract]

Erastin-induced cell death in lung cancer cells is almost blocked by cotreatment with the Ferrostatin-1 (Fer-1; 24 h) in H460 and H1299 cells.
Nature

Catabolism of extracellular glutathione supplies cysteine to support tumours. [Abstract]

2026 May;653(8115):933-941. PMID: 41851454
Cancer Cell

Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma. [Abstract]

2026 Feb 9;44(2):383-404.e18. PMID: 41544627
Science

Iron-catalyzed active lipid peroxides drive ultrafast collective cell death in blooming algae. [Abstract]

2026 Jun 25;392(6805):eaed3823. PMID: 42348688
Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018
Cell

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. [Abstract]

2025 Aug 21;188(17):4567-4585.e32. PMID: 40532699

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cell. 2025 Aug 21;188(17):4567-4585.e32. [Abstract]

Cell viability (RU) of mScarlet control, IFNγOE, PSMB8OE, and PFKFB-overexpressing neurons (PFKFB3OE) treated with 10 μM ferrostatin-1 (Fer1) or 1 μM liproxstatin-1 (Lip1) prior to exposure to 50 μM glutamate (D) or 6 μM RSL3 (E) for 15 h (n = 5).
Cell

SLC7A11 is an unconventional H+ transporter in lysosomes. [Abstract]

2025 Jun 26;188(13):3441-3458.e25. PMID: 40280132
Cell

Red blood cells undergo lytic programmed cell death involving NLRP3. [Abstract]

2025 May 29;188(11):3013-3029.e19. PMID: 40252640
Cell

Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. [Abstract]

2024 Feb 1;187(3):624-641.e23. PMID: 38211590
Imeta

2026 Jun 14.
Mol Cancer

HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4-ERK1/2-U2AF2-TFRC axis. [Abstract]

2025 Oct 2;24(1):241. PMID: 41039452
Cell Metab

Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]

2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214
Cell Res

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. [Abstract]

2023 Dec;33(12):904-922. PMID: 37460805
Cancer Discov

C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia. [Abstract]

2023 Jul 7;13(7):1720-1747. PMID: 37012202

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2023 Jul 7;13(7):1720-1747. [Abstract]

MOLM-14 cells were depleted of GPX4 using CRISPR-Cas9, and cultured with Ferrostatin-1 (Fer-1) (10 μmol/L; 60-600 min). Cell viability [using propidium iodide (PI) staining] and lipid peroxidation (using C11-BODIPY staining) were measured without or with Fer-1 dependent on time.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2023 Jul 7;13(7):1720-1747. [Abstract]

Cell viability assays using Alamar Blue in MOLM-14 (left) and MV4-11 (right) cells overexpressing SCD (SCD-OE) or the empty vector, and incubated with dose-range RSL3 for 14 hours, and with vehicle or 10 μmol/L ferrostatin-1 (Fer-1).
Adv Mater

NIR-Actuated Ferroptosis Nanomotor for Enhanced Tumor Penetration and Therapy. [Abstract]

2024 Dec;36(49):e2412227. PMID: 39370589

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec;36(49):e2412227. [Abstract]

Ferrostatin-1 (1 μM; 24 h) inhibits Z@P-F+NIR-induced ROS production and reversed mitochondrial dysfunction in 4T1 cells.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec;36(49):e2412227. [Abstract]

Ferrostatin-1 (1 μM; 24 h) suppresses the downregulation of GPX4 and SLC7A11 proteins induced by Z@P-F+NIR, thereby reversing ferroptosis effects in 4T1 cells.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec;36(49):e2412227. [Abstract]

Ferrostatin-1 (Fer-1; 1 μM; 12 h). The ratios of 4T1 cells after different treatments. Live cells are stained with AM (green) and dead cells are stained with PI (red), (n = 3, scale bar = 100 μm).
Adv Mater

Combating Atherosclerosis with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment-Programmed Senolytic and Senomorphic Actions. [Abstract]

2024 Jul;36(29):e2401361. PMID: 38721975

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Jul;36(29):e2401361. [Abstract]

Lipid peroxidation in cells as visualized by BODIPY-C11 dye. Fluorescence emitted from BODIPY in an oxidative (O-BODIPY, green) and reduced form (R-BODIPY, red) represents oxidized and pristine lipids, respectively. Nuclei of cells was counterstained with DAPI (blue). NC: Normal control; mitomycin C (MMC): Senescent cells induced by MMC treatment; MMC+D-PtPd2CuFe +/− Fer-1: Senescent cells received D-PtPd2CuFe w/wo treatment with Fer-1 (10 μM, 24 h) in prior, respectively.
Adv Mater

Impairing Tumor Metabolic Plasticity via a Stable Metal-Phenolic-Based Polymeric Nanomedicine to Suppress Colorectal Cancer. [Abstract]

2023 Jun;35(23):e2300548. PMID: 36917817
Cancer Commun (Lond)

2026 Feb 19:46:0005. PMID: 41727907
Cancer Commun (Lond)

N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA. [Abstract]

2022 Dec;42(12):1347-1366. PMID: 36209353

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2022 Dec;42(12):1347-1366. [Abstract]

A CCK-8 assay was used to analyze the effect of Ferrostatin-1 (1μM) on the proliferation of NAT10-knockdown colon cancer cells(n = 3).

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2022 Dec;42(12):1347-1366. [Abstract]

EdU‐positive cell numbers were quantified in the tumors derived from HT‐29 (shNC and shNAT10) cells with and without Ferrostatin‐1 (1μM) treatment (n = 5).
Nat Cancer

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]

2025 May;6(5):768-785. PMID: 40108413
Nat Immunol

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]

2025 Oct;26(10):1660-1672. PMID: 40954252
Int J Extrem Manuf

2025 Jan 24.
Nat Aging

Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury. [Abstract]

2024 Jun;4(6):771-782. PMID: 38724734
Bioact Mater

Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening. [Abstract]

2023 Dec 3:33:483-496. PMID: 38125638

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Dec 3:33:483-496. [Abstract]

Ferrostain-1 (Fer-1) (100-400 nM; 24 h) significantly inhibits the decrease in 4T1 cell viability induced by CMS.
Bioact Mater

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. [Abstract]

2021 Nov 19;13:23-36. PMID: 35224289

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]

H1299 and H460 cells are treated with Curcumenol with or without Ferrostatin-1 (Fer-1; 1 μM) for 24 h, and the cell viability is analyzed.
Cell Host Microbe

Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis. [Abstract]

2026 Jan 14;34(1):35-51.e9. PMID: 41500222
Nat Cell Biol

Stress granules restrain ferroptosis by sequestering ferritin. [Abstract]

2026 Jun;28(6):1204-1218. PMID: 42174134
Nat Cell Biol

A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis. [Abstract]

2025 Aug;27(8):1288-1300. PMID: 40681752
Nat Cell Biol

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer. [Abstract]

2025 Apr;27(4):641-653. PMID: 40033101
Nat Cell Biol

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. [Abstract]

2024 Sep;26(9):1470-1481. PMID: 39009641
Nat Cell Biol

De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence. [Abstract]

2023 Jun;25(6):836-847. PMID: 37291265

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Jun;25(6):836-847. [Abstract]

Cell viability of HeLa cells treated with BQR (0.3 μM) and/or AICAR (40 μM)/A-769662 (200 μM)/MK-8722 (1 μM) for 72 h following pretreatment with vehicle or ferrostatin-1 (Ferr-1, 10 μM) for 24 h.
Cancer Res

TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Jul 15;86(14):3436-3458. PMID: 41974002
Cancer Res

Lactate-Activated GPR132 Signaling Drives a Tumor Microenvironmental Autocrine Metabolic Loop in Kidney Cancer. [Abstract]

2026 Jun 6. PMID: 42258526
Cancer Res

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer. [Abstract]

2025 Sep 24. PMID: 40991294
Cancer Res

CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer. [Abstract]

2025 Aug 29. PMID: 40882016
Drug Resist Updat

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]

2025 Jul:81:101224. PMID: 40058099
J Extracell Vesicles

Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. [Abstract]

2024 Feb;13(2):e12410. PMID: 38320981
Bone Res

Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. [Abstract]

2025 Jan 16;13(1):9. PMID: 39814705
Bone Res

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. [Abstract]

2024 Aug 27;12(1):47. PMID: 39191757

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 27;12(1):47. [Abstract]

Cell death induced by HOXC10 inhibition plus TTI-101 cotreatment was rescued by ferroptosis inhibitors. Cells with or without knockdown of HOXC10 were pretreated with HOXC10 TTI-101 for 12 h and then treated the indicated cell death inhibitors (3-MA-1 mmol/L, Necrostatin-1-20 μmol/L, Ferrostatin-1-2 μmol/L, Z-VAD-FMK-10 μmol/L, Glutathione-1 mmol/L, Deferoxamine (DFO-100 μmol/L)) for an additional 72 h. Effect on ferroptosis inhibitors rescuing cell death was assessed by cell viability assays.
Adv Funct Mater

2025 Jan 19.
Adv Funct Mater

2023 May 14.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2023 May 14.

The viability of MC38 cells treated with PAD@MS for 48 h in the presence or absence of 10 µM Ferr-1 (Ferrostatin-1), 20 µM Nec-1, 10 µM Z-VAD-FMK, and 1 mM NAC.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2023 May 14.

The viability of MC38 cells treated with (A) MTO, (B) SAS, (C) M+S, and (D) PD@MS for 48 h in the presence or absence of 10 µM Ferr-1, 20 µM Nec-1, 10 µM Z-VADFMK, and 1 mM NAC
Autophagy

RETREG1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis. [Abstract]

2026 Jun;22(6):1287-1305. PMID: 41787734
Autophagy

PRKN-IMMT/MIC60 axis promotes myocardial ischemia-reperfusion injury via lysosomal degradation of GPX4. [Abstract]

2026 May 14. PMID: 42132226
Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599
Autophagy

Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis. [Abstract]

2025 Oct;21(10):2091-2110. PMID: 40160153
Autophagy

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury. [Abstract]

2025 Jul;21(7):1473-1491. PMID: 40000916
Autophagy

SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury. [Abstract]

2025 May 19:1-18. PMID: 40366738
Nat Commun

2026 Jul 8;17(1):8447. PMID: 42420321
Nat Commun

KIF11 prevents retinal endothelial ferroptosis in familial exudative vitreoretinopathy by inhibiting phosphorylation-driven PRDX1 phase separation. [Abstract]

2026 Mar 24;17(1):4360. PMID: 41872221
Nat Commun

Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies. [Abstract]

2025 Dec 13. PMID: 41390693
Nat Commun

Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel. [Abstract]

2025 Dec 16;16(1):11045. PMID: 41402297
Nat Commun

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis. [Abstract]

2025 Dec 8. PMID: 41361241
Nat Commun

Spatially blocked split CRISPR-Cas12a system for ultra-sensitive and versatile small molecule activation and detection. [Abstract]

2025 May 30;16(1):5035. PMID: 40447601
Nat Commun

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes. [Abstract]

2025 Apr 1;16(1):3131. PMID: 40169595
Nat Commun

IDH status dictates oHSV mediated metabolic reprogramming affecting anti-tumor immunity. [Abstract]

2025 Apr 24;16(1):3874. PMID: 40274791
Nat Commun

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma. [Abstract]

2025 Jan 31;16(1):1212. PMID: 39890789
Nat Commun

Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity. [Abstract]

2024 Oct 8;15(1):8696. PMID: 39379392
Nat Commun

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress. [Abstract]

2022 Nov 17;13(1):7031. PMID: 36396642
Exp Mol Med

Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis. [Abstract]

2023 May;55(5):939-951. PMID: 37121969
Exp Mol Med

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. [Abstract]

2022 Nov;54(11):2007-2021. PMID: 36385558
ACS Nano

Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy. [Abstract]

2025 Jul 1;19(25):23315-23333. PMID: 40534228
ACS Nano

Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma. [Abstract]

2025 Jun 10;19(22):21105-21117. PMID: 40424612

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Jun 10;19(22):21105-21117. [Abstract]

The protein levels of ERα markers in BEAS-2B cells cocultured with indicated dEoL-1 cells for 48 h with or without Ferrostatin-1 (Fer-1, 1 μM) pretreatment for 2 h.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Jun 10;19(22):21105-21117. [Abstract]

Cell viability of BEAS-2B cells after coculturing with indicated dEoL-1 cells for 24 h with or without Ferrostatin-1 (Fer-1, 1 μM) or Deferoxamine (DFO, 100 μM) pretreatment.
ACS Nano

Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction. [Abstract]

2024 Jul 2;18(26):16790-16807. PMID: 38869479

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

TC-1 cells were pretreated with Ferrostatin-1 (Fer-1, 1 μM) or DFO (50 μM) for 1 h, followed by NP treatment for another 24 h. CCK8 results showed that pretreatment with Fer-1 could effectively inhibit the cell death induced by NPs (n = 3).
ACS Nano

Glutathione-Exhausting Nanoprobes for NIR-II Fluorescence Imaging-Guided Surgery and Boosting Radiation Therapy Efficacy via Ferroptosis in Breast Cancer. [Abstract]

2023 Jun 27;17(12):11345-11361. PMID: 37272787

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Jun 27;17(12):11345-11361. [Abstract]

Western blot assays of the levels of GPX4 protein in 4T1 cells after VGd@ICG-FA inhibition and the level were reversed by Ferrostatin 1 (5 μM).

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Jun 27;17(12):11345-11361. [Abstract]

Cell viability analysis of 4T1 cells after incubation with different formulations for 36 h.
ACS Nano

Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy. [Abstract]

2023 May 23;17(10):9126-9139. PMID: 37097811
J Adv Res

Targeting myofibroblast copper vulnerability reverses pulmonary fibrosis via METTL3-directed STAT6 m6A driving cuproptosis. [Abstract]

2026 May 21:S2090-1232(26)00436-4. PMID: 42173361
J Adv Res

Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis. [Abstract]

2026 May 3:S2090-1232(26)00381-4. PMID: 42086188
J Adv Res

DHA ameliorates GDM placental angiogenesis by regulating HAMP-mediated iron imbalance. [Abstract]

2026 Mar 9:S2090-1232(26)00224-9. PMID: 41812706
J Adv Res

MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis. [Abstract]

2025 Oct 10:S2090-1232(25)00764-7. PMID: 41077348
J Adv Res

NCOA4-Mediated Ferritinophagy Induces Ferroptosis and Enriches Ferritin-Containing EVs via Ferritin Phase Separation to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis. [Abstract]

2025 Jul 28:S2090-1232(25)00571-5. PMID: 40738474
J Adv Res

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo. [Abstract]

2025 Jul 12:S2090-1232(25)00545-4. PMID: 40659088
J Adv Res

SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice. [Abstract]

2025 May:71:369-381. PMID: 38797476
J Adv Res

Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis. [Abstract]

2025 Mar:69:515-529. PMID: 38621621
J Adv Res

Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments. [Abstract]

2025 Feb 8:S2090-1232(25)00107-9. PMID: 39929269
J Adv Res

Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis. [Abstract]

2024 Dec 6:S2090-1232(24)00554-X. PMID: 39647633
Cell Discov

Bergeyella cardium variant induces a unique cytoplasmic vacuolization cell death floatptosis in macrophage. [Abstract]

2025 Oct 21;11(1):83. PMID: 41115953
Cell Discov

Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma. [Abstract]

2025 Oct 7;11(1):81. PMID: 41057295
Cell Discov

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. [Abstract]

2025 Mar 11;11(1):22. PMID: 40064862
Neuron

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. [Abstract]

2024 Oct 23;112(20):3452-3469.e9. PMID: 39153477
Cell Discov

Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. [Abstract]

2022 May 3;8(1):40. PMID: 35504898

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

U2OS cells are incubated with DMSO or OSMI-1 for 12 h and then pre-treated with Ferrostatin-1 (Fer-1; 2 μM) for 2 h before the treatment of RSL3 for 4 h. Cells are stained with PI and cell death is then assessed by flow cytometry.
Redox Biol

2026 Sep:95:104315. PMID: 42472512
Redox Biol

2026 Jul 13. PMID: 42537476
Redox Biol

DNMT1-DUOXA1 axis discovers a novel methylation-ferroptosis circuit in bicalutamide-resistant prostate cancer. [Abstract]

2026 Jul:94:104188. PMID: 42097033
Redox Biol

Piceatannol-3'-O-β-d-glucopyranoside mitigates myocardial ischemia-reperfusion injury by inhibiting ferroptosis through the regulation of NDUFS1 lactylation via metabolic reprogramming. [Abstract]

2026 Jul:94:104198. PMID: 42134300
Redox Biol

2026 Jul 20:96:104311. PMID: 42537477
Redox Biol

CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ. [Abstract]

2026 Jun 13:95:104259. PMID: 42289168
Redox Biol

Ionizing radiation promotes lung injury by inducing ferroptosis-driven senescence in epithelial cells via NCOA4-mediated ferritinophagy. [Abstract]

2026 Apr:91:104091. PMID: 41722510
Redox Biol

Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells. [Abstract]

2026 Apr:91:104088. PMID: 41734579
Redox Biol

Neutrophil Irgm1 ameliorates sepsis-induced myocardial dysfunction by promoting Alox15 degradation. [Abstract]

2026 May:92:104104. PMID: 41795420
Redox Biol

USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers. [Abstract]

2026 May:92:104086. PMID: 41844497
Redox Biol

Genetically engineered Escherichia coli Nissle 1917 enabling on-site melanin synthesis attenuates radiation enteritis through ferroptosis inhibition and gut microbiota modulation. [Abstract]

2026 May:92:104141. PMID: 41903318
Redox Biol

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]

2026 Mar:90:104043. PMID: 41604941
Redox Biol

YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion. [Abstract]

2025 Oct:86:103811. PMID: 40763655
Redox Biol

LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer. [Abstract]

2025 Sep:85:103722. PMID: 40505346
Redox Biol

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells. [Abstract]

2025 May:82:103614. PMID: 40156957
Redox Biol

Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1. [Abstract]

2025 May:82:103597. PMID: 40107016
Redox Biol

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux. [Abstract]

2025 Apr:81:103557. PMID: 39986118
Redox Biol

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis. [Abstract]

2025 Mar:80:103528. PMID: 39922130
Redox Biol

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]

2025 Feb:79:103460. PMID: 39657365
Redox Biol

PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis. [Abstract]

2024 Dec:78:103417. PMID: 39549609
Redox Biol

Over-activation of iNKT cells aggravate lung injury in bronchopulmonary dysplasia mice. [Abstract]

2024 Nov:77:103370. PMID: 39342744
Redox Biol

Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD. [Abstract]

2024 Nov:77:103388. PMID: 39374556
Redox Biol

Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma. [Abstract]

2024 Oct:76:103328. PMID: 39216271
Redox Biol

Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells. [Abstract]

2024 Oct:76:103312. PMID: 39173539
Redox Biol

Plasma-generated RONS in liquid transferred into cryo-microneedles patch for skin treatment of melanoma. [Abstract]

2024 Sep:75:103284. PMID: 39059203
Redox Biol

FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]

2024 Aug:74:103225. PMID: 38875957
Redox Biol

ARID3A enhances chemoresistance of pancreatic cancer via inhibiting PTEN-induced ferroptosis. [Abstract]

2024 Jul:73:103200. PMID: 38781729
Redox Biol

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]

2024 Jul:73:103207. PMID: 38805974
Redox Biol

The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. [Abstract]

2024 Jun:72:103145. PMID: 38583415
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

Breast cancer cells have an increased ferroptosis risk induced by system xc- blockade after deliberately downregulating CYTL1 to mediate malignancy. [Abstract]

2024 Apr:70:103034. PMID: 38211443
Redox Biol

EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage. [Abstract]

2024 Apr:70:103075. PMID: 38364686
Redox Biol

Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. [Abstract]

2023 Dec:68:102970. PMID: 38035662
Redox Biol

Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. [Abstract]

2023 Oct:66:102857. PMID: 37611494
Redox Biol

Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer. [Abstract]

2023 Feb:59:102564. PMID: 36473315
Redox Biol

HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma. [Abstract]

2022 Dec:58:102546. PMID: 36423520
Redox Biol

Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model. [Abstract]

2022 Nov:57:102509. PMID: 36302319
Redox Biol

Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. [Abstract]

2022 Oct;56:102435. PMID: 36029649

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct;56:102435. [Abstract]

Primary HSCs and LX-2 cells are treated with EA (LX-2 cells: 40 μM; primary HSCs: 45 μM), Ferrostatin-1 (1 μM) and ZVAD-FMK (10 μM), and cells are stained with PI (red fluorescence) to examine the dead cells.
Redox Biol

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer. [Abstract]

2022 Aug 4;55:102426. PMID: 35963119
Redox Biol

Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. [Abstract]

2022 Jul 31;55:102408. PMID: 35944469
Redox Biol

Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes. [Abstract]

2022 Jun:52:102320. PMID: 35462320
Redox Biol

T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2. [Abstract]

2022 Apr;50:102257. PMID: 35149342
Redox Biol

ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance. [Abstract]

2021 Jul:43:101977. PMID: 33905957
Redox Biol

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. [Abstract]

2020 Jan:29:101402. PMID: 31926626
Mol Cell

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer. [Abstract]

2026 Apr 2;86(7):1260-1274.e4. PMID: 41932308
Mol Cell

mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway. [Abstract]

2026 Apr 16;86(8):1546-1559.e8. PMID: 41997112
Gut Microbes

Faecalibacterium prausnitzii prevents age-related heart failure by suppressing ferroptosis in cardiomyocytes through butyrate-mediated LCN2 regulation. [Abstract]

2025 Dec;17(1):2505119. PMID: 40364435
Gut Microbes

PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation. [Abstract]

2023 Dec;15(2):2265578. PMID: 37800577
J Nanobiotechnology

Dual metabolic intervention nanoplatform co-delivering BAY-876 and L-cystine for Wilms tumor therapy via disulfidptosis-associated cytoskeletal collapse. [Abstract]

2026 Jun 10. PMID: 42271349
J Nanobiotechnology

Ag2Se quantum dots neurotoxicity: mitochondrial stress drives ferroptosis-dependent microglial inflammation. [Abstract]

2026 Apr 2;24(1):431. PMID: 41928263
J Nanobiotechnology

Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer. [Abstract]

2025 Aug 12;23(1):562. PMID: 40797208
J Nanobiotechnology

Ferrocene-derived magnetic fiber-particles from diesel exhaust: enhanced pulmonary toxicity via Bach1-SAT1-polyamine depletion. [Abstract]

2025 Apr 29;23(1):324. PMID: 40301891
J Nanobiotechnology

Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity. [Abstract]

2025 Feb 14;23(1):109. PMID: 39953537
J Nanobiotechnology

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy. [Abstract]

2024 Dec 18;22(1):758. PMID: 39696565
J Nanobiotechnology

miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts. [Abstract]

2022 Apr 22;20(1):196. PMID: 35459211
Theranostics

Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury. [Abstract]

2025 Aug 16;15(17):9131-9158. PMID: 40963901
Theranostics

Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy. [Abstract]

2025 Jun 9;15(14):6665-6685. PMID: 40585993
Theranostics

Hypoxia inducible factor (HIF) 3α prevents COPD by inhibiting alveolar epithelial cell ferroptosis via the HIF-3α-GPx4 axis. [Abstract]

2024 Aug 28;14(14):5512-5527. PMID: 39310101
Theranostics

Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis. [Abstract]

2020 Aug 2;10(21):9865-9887. PMID: 32863964

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Aug 2;10(21):9865-9887. [Abstract]

p53 expression of HepG2 cells after treated with Fer-1 at a concentration of 0-40 nM. The addition of Fer-1 could repress the expression of p53 protein by inhibiting the ferroptosis of SFB formulation.
Theranostics

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. [Abstract]

2020 Apr 6;10(11):5107-5119. PMID: 32308771
Genes Dis

2026 Jun 15.
Acta Pharm Sin B

2026 Mar 3.
Genes Dis

2026 Mar 19.
Genes Dis

2025 Dec 24.
Acta Pharm Sin B

2025 Oct 28.
Acta Pharm Sin B

High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming. [Abstract]

2025 Jul;15(7):3788-3804. PMID: 40698150
Acta Pharm Sin B

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]

2024 Aug;14(8):3493-3512. PMID: 39220878
Biomark Res

Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling. [Abstract]

2024 Jan 25;12(1):13. PMID: 38273343
Acta Pharm Sin B

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. [Abstract]

2021 Dec;11(12):3966-3982. PMID: 35024319
J Biomed Sci

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis. [Abstract]

2025 Jan 13;32(1):8. PMID: 39800682
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Exp Clin Cancer Res

Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1. [Abstract]

2023 May 19;42(1):127. PMID: 37202791
J Exp Clin Cancer Res

L-kynurenine induces NK cell loss in gastric cancer microenvironment via promoting ferroptosis. [Abstract]

2023 Mar 1;42(1):52. PMID: 36855135
J Exp Clin Cancer Res

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. [Abstract]

2022 Oct 20;41(1):307. PMID: 36266731
J Exp Clin Cancer Res

Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma. [Abstract]

2022 Jan 3;41(1):3. PMID: 34980204
J Exp Clin Cancer Res

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. [Abstract]

2021 Jun 23;40(1):206. PMID: 34162423

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2021 Jun 23;40(1):206. [Abstract]

T47D cells are treated with Metformin (5 mM) for 48 h in the absence or presence of Ferrostatin-1 (1 μM) for 48 h.
Adv Sci (Weinh)

Penfluridol Triggers GSDME-Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy. [Abstract]

2026 Jul 3:e76408. PMID: 42396980
Adv Sci (Weinh)

2026 Jul 13:e76586. PMID: 42439361
Adv Sci (Weinh)

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis. [Abstract]

2026 Jul;13(37):e75216. PMID: 42003743
Adv Sci (Weinh)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin-Mediated NRF2 Degradation. [Abstract]

2026 Jun;13(36):e75157. PMID: 41945797
Adv Sci (Weinh)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer. [Abstract]

2026 May 25:e75818. PMID: 42183833
Adv Sci (Weinh)

Targeting the GPX4-FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis-Associated Lung Injury. [Abstract]

2026 Apr;13(20):e16488. PMID: 41616122
Adv Sci (Weinh)

Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis. [Abstract]

2026 Apr;13(19):e15768. PMID: 41589658
Adv Sci (Weinh)

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [Abstract]

2026 Mar;13(16):e13310. PMID: 41589654
Adv Sci (Weinh)

Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [Abstract]

2025 Nov 30:e14349. PMID: 41319283
Adv Sci (Weinh)

NARFL Knockout Triggers Ferroptosis-Driven Vascular Endothelial Dysfunction. [Abstract]

2025 Nov 30:e15580. PMID: 41319277
Adv Sci (Weinh)

NADH-Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis. [Abstract]

2025 Dec 5:e20444. PMID: 41346305
Adv Sci (Weinh)

Fe-S Protein FDX1 Triggers Tumor-Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC. [Abstract]

2025 Nov 7:e18323. PMID: 41199656
Adv Sci (Weinh)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke. [Abstract]

2025 Nov 6:e07384. PMID: 41195589
Adv Sci (Weinh)

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway. [Abstract]

2025 Oct 13:e12599. PMID: 41082335
Adv Sci (Weinh)

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction. [Abstract]

2025 Oct 6:e04817. PMID: 41051274
Adv Sci (Weinh)

CHAC1 Mediates Endoplasmic Reticulum Stress-Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation. [Abstract]

2025 Mar;12(10):e2403992. PMID: 39836526
Adv Sci (Weinh)

Dexmedetomidine Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting MDH2 Lactylation via Regulating Metabolic Reprogramming. [Abstract]

2024 Dec;11(48):e2409499. PMID: 39467114
Adv Sci (Weinh)

Mitochondrial Dysfunction-Evoked DHODH Acetylation is Involved in Renal Cell Ferroptosis during Cisplatin-Induced Acute Kidney Injury. [Abstract]

2024 Nov;11(43):e2404753. PMID: 39303219
Adv Sci (Weinh)

Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death. [Abstract]

2024 Aug;11(30):e2401396. PMID: 38859590
Adv Sci (Weinh)

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome-lysosome Fusion in NSCLC. [Abstract]

2024 Aug;11(31):e2308307. PMID: 39166458
MedComm (2020)

A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury. [Abstract]

2024 Jun 5;5(6):e571. PMID: 38840772
Adv Sci (Weinh)

Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis. [Abstract]

2024 Jun;11(23):e2310134. PMID: 38634567
MedComm

Antiferroptosis therapy alleviated the development of atherosclerosis. [Abstract]

2024 Apr 4;5(4):e520. PMID: 38576455
Adv Sci (Weinh)

VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy. [Abstract]

2024 Mar;11(10):e2305563. PMID: 38145959
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts. [Abstract]

2023 Aug;10(24):e2300881. PMID: 37341301
Adv Sci (Weinh)

Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus. [Abstract]

2023 Jun;10(17):e2206869. PMID: 37092591
Adv Sci (Weinh)

The Imbalance of p53-Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin-Challenged Cardiomyocytes. [Abstract]

2023 May;10(15):e2206007. PMID: 36967569
MedComm (2020)

Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells. [Abstract]

2021 Dec 16;2(4):821-837. PMID: 34977879
Cell Rep Med

2026 Aug 18;7(8):102928. PMID: 42486098
Cell Rep Med

Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds. [Abstract]

2026 Apr 21;7(4):102714. PMID: 41916295
Cell Rep Med

HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer. [Abstract]

2026 Feb 18:102630. PMID: 41713410
Cell Rep Med

5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation. [Abstract]

2026 Jan 20;7(1):102537. PMID: 41494533
Cell Rep Med

Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]

2025 Sep 25:102371. PMID: 41005298
Cell Rep Med

High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy. [Abstract]

2025 Aug 12:102291. PMID: 40818456
Sci Adv

Athlete-derived extracellular vesicles protect against spinal cord injury via inhibition of neuronal ferroptosis. [Abstract]

2025 Dec 12;11(50):eadx7695. PMID: 41385620
Sci Adv

HERVH-derived eRNA activates a super-enhancer-driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development. [Abstract]

2025 Dec 12;11(50):eaea9074. PMID: 41370380
Sci Adv

BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis. [Abstract]

2025 Jul 11;11(28):eadw1720. PMID: 40644536
Sci Adv

Endogenous/exogenous dual-responsive nanozyme for photothermally enhanced ferroptosis-immune reciprocal synergistic tumor therapy. [Abstract]

2025 May 16;11(20):eadq3870. PMID: 40367177
Sci Adv

RIPK3 deficiency blocks R-2-hydroxyglutarate-induced necroptosis in IDH-mutated AML cells. [Abstract]

2024 Apr 19;10(16):eadi1782. PMID: 38630819
Sci Adv

Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases. [Abstract]

2024 Mar 29;10(13):eadk1200. PMID: 38552012
Sci Adv

Ferroptosis MRI for early detection of anticancer drug-induced acute cardiac/kidney injuries. [Abstract]

2023 Mar 10;9(10):eadd8539. PMID: 36888714
Cell Death Differ

FAM96A functions as a novel pace controller for iron uptake to maintain iron homeostasis and erythropoiesis. [Abstract]

2026 Apr 1. PMID: 41922801
Cell Death Differ

GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM). [Abstract]

2026 Mar 5. PMID: 41787053
Cell Death Differ

Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination. [Abstract]

2026 Mar 2. PMID: 41772062
Cell Death Differ

MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer. [Abstract]

2025 Dec 19. PMID: 41420103
Cell Death Differ

PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury. [Abstract]

2025 Oct 7. PMID: 41057687
Cell Death Differ

AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]

2025 Sep 23. PMID: 40987895
Cell Death Differ

Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. [Abstract]

2025 Jun;32(6):1041-1057. PMID: 39875520
Biomaterials

Reverse magnetic resonance tuning nanoplatform with heightened sensitivity for non-invasively multiscale visualizing ferroptosis-based tumor sensitization therapy. [Abstract]

2025 Apr:315:122935. PMID: 39489017
Cell Death Differ

The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. [Abstract]

2025 Mar;32(3):506-520. PMID: 39478199
Biomaterials

A versatile nanoplatform carrying cascade Pt nanozymes remodeling tumor microenvironment for amplified sonodynamic/chemo therapy of thyroid cancer. [Abstract]

2025 Feb:313:122778. PMID: 39213978
Cell Death Differ

Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells. [Abstract]

2024 Nov;31(11):1452-1466. PMID: 38987382
Cell Death Differ

The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. [Abstract]

2023 Jul;30(7):1757-1770. PMID: 37173391
Cell Death Differ

Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction. [Abstract]

2023 Mar;30(3):825-838. PMID: 36639542
Cell Death Differ

PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway. [Abstract]

2022 Oct;29(10):1982-1995. PMID: 35383293
Cell Death Differ

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. [Abstract]

2021 Apr;28(4):1222-1236. PMID: 33097833
Carbohydr Polym

Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy. [Abstract]

2025 Mar 1:351:123123. PMID: 39779030
Chem Eng J

2026 Jul 17.
Chem Eng J

2025 Sep 19;523:168705.
Chem Eng J

2025 Aug 1.
Chem Eng J

2024 Nov 28.
Chem Eng J

2023 Oct 17, 146749.
Chem Eng J

2023 Jun 15, 466, 143104.
J Control Release

In situ delivery of JPH203 via camptothecin-peptide conjugate nanoassemblies to trigger ferroptosis in triple-negative breast cancer. [Abstract]

2026 May 10:393:114829. PMID: 41839266
J Control Release

Inducing potent ferroptosis in cancer cells by manipulation of ferritinophagy with a ferritin-targeted ATTEC. [Abstract]

2026 Jan 10:389:114450. PMID: 41274571
J Control Release

Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition. [Abstract]

2025 May 10:381:113598. PMID: 40043912
J Control Release

Laser-responsive erastin-loaded chondroitin sulfate nanomedicine targeting CD44 and system xc- in liver cancer: A non-ferroptotic approach. [Abstract]

2024 Nov:375:574-588. PMID: 39293529
Cell Mol Biol Lett

2026 Jul 8. PMID: 42420830
Cell Death Dis

2026 Jul 1. PMID: 42380121
Cell Death Dis

Inflammation impairs fertility and oocyte quality in systemic lupus erythematosus by triggering oxidative stress-mediated ferroptosis. [Abstract]

2026 Jun 30. PMID: 42380111
Cell Death Dis

Sunitinib enhances cuproptosis induced by copper ionophores via ROS-ATF3-SLC31A1 axis in thyroid Carcinoma. [Abstract]

2026 Jun 1. PMID: 42225617
Cell Death Dis

Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging. [Abstract]

2026 May 23. PMID: 42177202
Cell Death Dis

IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury. [Abstract]

2026 Mar 23;17(1):350. PMID: 41872158
Cell Death Dis

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis. [Abstract]

2026 Mar 27;17(1):413. PMID: 41896546
Cell Death Dis

PGC-1α protects against MASH via Tim23-dependent inhibition of DRP1-mediated ferroptosis. [Abstract]

2026 Feb 23;17(1):246. PMID: 41724762
Cell Death Dis

Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells. [Abstract]

2025 Dec 18. PMID: 41413023
Cell Death Dis

2025 Dec 1.
Pharmacol Res

ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction. [Abstract]

2025 Dec:222:108029. PMID: 41205728
Cell Death Dis

Elovl7 sensitizes podocytes to ferroptosis in podocytopathy by elongating polyunsaturated fatty acids. [Abstract]

2025 Nov 24;16(1):857. PMID: 41285716
Cell Death Dis

SETD7-mediated H3K4me1 activates ALDH1A3 to drive ferroptosis resistance in esophageal squamous cell carcinoma. [Abstract]

2025 Nov 7;16(1):810. PMID: 41203594
Environ Sci Technol

Bisphenol A Disrupts Spermatogenesis via Excessive Mitophagy-Driven Ferroptosis. [Abstract]

2025 Oct 28;59(42):22423-22438. PMID: 41104744
Environ Sci Technol

Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets. [Abstract]

2025 Oct 21;59(41):21898-21909. PMID: 41068997
Cell Mol Biol Lett

PPARγ-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis. [Abstract]

2025 Oct 28;30(1):128. PMID: 41152705
Cell Mol Biol Lett

RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis. [Abstract]

2025 Oct 2;30(1):109. PMID: 41039223
Cell Death Dis

YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer. [Abstract]

2025 Sep 1;16(1):589. PMID: 40890129
Cell Death Dis

DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. [Abstract]

2025 Aug 28;16(1):654. PMID: 40877242
Cell Death Dis

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. [Abstract]

2025 Jul 23;16(1):549. PMID: 40695795
Cell Death Dis

(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway. [Abstract]

2025 Jul 23;16(1):548. PMID: 40695797
Cell Death Dis

Ferroptosis mediated by the IDO1/Kyn/AhR pathway triggers acute thymic involution in sepsis. [Abstract]

2025 Jul 25;16(1):562. PMID: 40715082
Cell Death Dis

Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2. [Abstract]

2025 Jul 11;16(1):513. PMID: 40645965
Cell Death Dis

Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore. [Abstract]

2025 Jul 1;16(1):482. PMID: 40592836
Cell Death Dis

IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma. [Abstract]

2025 Jul 11;16(1):512. PMID: 40645933
Cell Death Dis

A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP. [Abstract]

2025 May 19;16(1):403. PMID: 40389408
Cell Death Dis

A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis. [Abstract]

2025 Apr 14;16(1):291. PMID: 40229247
Cell Death Dis

Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. [Abstract]

2025 Apr 5;16(1):254. PMID: 40185704
Cell Death Dis

BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer. [Abstract]

2025 Apr 24;16(1):337. PMID: 40274762
Cell Death Dis

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]

2025 Mar 20;16(1):193. PMID: 40113760
Cell Death Dis

Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway. [Abstract]

2025 Feb 3;16(1):64. PMID: 39900894
Pharmacol Res

Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis. [Abstract]

2025 Feb:212:107587. PMID: 39778639
Cell Death Dis

SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling. [Abstract]

2024 Nov 12;15(11):820. PMID: 39532848
Cell Death Dis

FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis. [Abstract]

2024 Nov 14;15(11):826. PMID: 39543094
Cell Death Dis

Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest. [Abstract]

2024 Nov 15;15(11):834. PMID: 39548081
Cell Death Dis

MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression. [Abstract]

2024 Nov 14;15(11):825. PMID: 39543140
Environ Sci Technol

Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis. [Abstract]

2024 Oct 1;58(39):17259-17269. PMID: 39208335
Cell Death Dis

Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4. [Abstract]

2024 Oct 5;15(10):729. PMID: 39368999
Cell Mol Biol Lett

Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer. [Abstract]

2024 Aug 28;29(1):113. PMID: 39198750
Cell Mol Biol Lett

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway. [Abstract]

2024 Jun 14;29(1):88. PMID: 38877424
Cell Mol Biol Lett

High-content image screening to identify chemical modulators for peroxisome and ferroptosis. [Abstract]

2024 Feb 17;29(1):26. PMID: 38368371
Cell Death Dis

Gp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis. [Abstract]

2023 Dec 8;14(12):810. PMID: 38065978
Cell Death Dis

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. [Abstract]

2023 Nov 25;14(11):767. PMID: 38007473
Cell Mol Biol Lett

Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis. [Abstract]

2023 Nov 25;28(1):95. PMID: 38007415
Pharmacol Res

PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma. [Abstract]

2023 Oct:196:106915. PMID: 37689128
Cell Death Dis

Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis. [Abstract]

2023 Oct 21;14(10):694. PMID: 37865653
Cell Death Dis

Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. [Abstract]

2023 Sep 4;14(9):588. PMID: 37666806
Cell Death Dis

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC. [Abstract]

2023 Aug 21;14(8):539. PMID: 37604811
Cell Death Dis

PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma. [Abstract]

2023 Mar 11;14(3):193. PMID: 36906674
Pharmacol Res

PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. [Abstract]

2023 Feb:188:106666. PMID: 36657504
Cell Death Dis

SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase. [Abstract]

2023 Jan 12;14(1):22. PMID: 36635256
Pharmacol Res

3'-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells. [Abstract]

2023 Jan:187:106613. PMID: 36535569
Cell Death Dis

Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis. [Abstract]

2022 Sep 26;13(9):825. PMID: 36163182
Cell Death Dis

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2. [Abstract]

2022 Aug 29;13(8):742. PMID: 36038548
Cell Death Dis

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. [Abstract]

2022 Jul 28;13(7):653. PMID: 35902564
Cell Death Dis

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling. [Abstract]

2022 Jul 20;13(7):630. PMID: 35859150
Cell Death Dis

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. [Abstract]

2022 Jul 4;13(7):579. PMID: 35787614
Cell Death Dis

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. [Abstract]

2022 May 20;13(5):479. PMID: 35595754
Cell Death Dis

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. [Abstract]

2022 May 30;13(5):507. PMID: 35637215
Cell Death Dis

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner. [Abstract]

2022 Jan 21;13(1):73. PMID: 35064112
Cell Death Dis

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. [Abstract]

2021 Nov 13;12(11):1079. PMID: 34775496
Cell Death Dis

Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. [Abstract]

2021 Oct 27;12(11):1009. PMID: 34707088
Cell Death Dis

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. [Abstract]

2021 Apr 30;12(5):426. PMID: 33931597
Cell Death Dis

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. [Abstract]

2021 Jan 11;12(1):65. PMID: 33431801
Cell Death Dis

Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. [Abstract]

2020 Nov 17;11(11):988. PMID: 33203867
Cell Death Dis

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. [Abstract]

2020 Sep 15;11(9):756. PMID: 32934217

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Sep 15;11(9):756. [Abstract]

Acot1 protein levels in different concentrations of DOX-treated HL-1 cell with or without Fer-1 (10 μM) for 24 h. Acot1 expression is decreased at a higher concentration of DOX, while Fer-1 co-treatment partially suppressed this trend.
Cell Death Dis

"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. [Abstract]

2020 Mar 13;11(3):183. PMID: 32170066
Cell Death Dis

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. [Abstract]

2019 Apr 15;10(5):331. PMID: 30988278
Small

Dynamically Reprograms Mitochondrial Respiration to Augment Cuproptosis in Cancer Therapy. [Abstract]

2026 Mar;22(18):e13435. PMID: 41653427
Small

Dual-Light-Primed GSH-Scavenging Lipid Hybrid Nanoplatform for Cascade-Activated Photodynamic Therapy. [Abstract]

2026 Feb 9:e12546. PMID: 41662168
Cancer Lett

Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression. [Abstract]

2025 Oct 10:630:217903. PMID: 40618880
Cancer Lett

Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response. [Abstract]

2025 Aug 10:625:217759. PMID: 40311913
Cancer Lett

SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis. [Abstract]

2025 Jul 28:623:217726. PMID: 40250791
Cancer Lett

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma. [Abstract]

2024 Aug 28:598:217092. PMID: 38945202
Small

New Sight of Renal Toxicity Caused by UV-Aged Polystyrene Nanoplastics: Induced Ferroptosis via Adsorption of Transferrin. [Abstract]

2024 Jun;20(23):e2309369. PMID: 38175859
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Small

Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization. [Abstract]

2023 Mar;19(10):e2206415. PMID: 36627264
Small

Biomimetic Activator of Sonodynamic Ferroptosis Amplifies Inherent Peroxidation for Improving the Treatment of Breast Cancer. [Abstract]

2022 Mar;18(12):e2106568. PMID: 35092152
Cancer Lett

UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer. [Abstract]

2021 Oct 28;519:2-19. PMID: 34161791
Small

A Ferrocene-Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis. [Abstract]

2021 Aug;17(32):e2101368. PMID: 34216420
Cancer Lett

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. [Abstract]

2021 Jul 10:510:93-104. PMID: 33872694

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 Jul 10:510:93-104. [Abstract]

Ferrostatin-1(2 μM) has the ability to fully restore the cell viability impaired by Erastin (5 μM) treated control cells in GBC-SD cells.
Int J Biol Sci

Canagliflozin and Brusatol Synergize against LKB1-KEAP1 Co-Mutant NSCLC through AKT Suppression. [Abstract]

2026 Apr 23;22(9):4618-4632. PMID: 42157939
Int J Biol Sci

Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis. [Abstract]

2025 Apr 28;21(7):3247-3261. PMID: 40384872
Int J Biol Sci

METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification. [Abstract]

2025 Jan 1;21(1):189-203. PMID: 39744432
J Immunother Cancer

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. [Abstract]

2024 Nov 24;12(11):e009805. PMID: 39581704
Int J Biol Sci

Novel LncRNA LINC02936 Suppresses Ferroptosis and Promotes Tumor Progression by Interacting with SIX1/CP Axis in Endometrial Cancer. [Abstract]

2024 Jan 27;20(4):1356-1374. PMID: 38385087
Int J Biol Sci

microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis. [Abstract]

2023 Aug 15;19(13):4223-4241. PMID: 37705752
Int J Biol Sci

Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer. [Abstract]

2023 May 8;19(8):2531-2550. PMID: 37215985
Int J Biol Sci

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis. [Abstract]

2023 Feb 13;19(4):1192-1210. PMID: 36923942
Int J Biol Sci

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. [Abstract]

2023 Feb 27;19(5):1471-1489. PMID: 37056925
Int J Biol Sci

Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells. [Abstract]

2022 Aug 29;18(14):5438-5458. PMID: 36147466
Int J Biol Sci

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. [Abstract]

2022 Aug 29;18(14):5459-5474. PMID: 36147463
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792
Int J Biol Sci

Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid. [Abstract]

2021 Mar 1;17(4):942-956. PMID: 33867820

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2021 Mar 1;17(4):942-956. [Abstract]

After the gallic acid treatment, Fe2+, ROS, and MDA are significantly increased compared to the control group, and at the same time, the content of GSH is significantly reduced. The intervention of Ferrostatin-1 (2 μM) while treating the cells with gallic acid reversed the changes in these indicators to varying degrees.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2021 Mar 1;17(4):942-956. [Abstract]

Gallic acid affects the expression of ferroptosis-related proteins. The relative expression levels of GPX4, SLC7A11, and SIGMAR1 decreased, while the relative expression levels of ATF4 and TFR1 increased. Ferrostatin-1 (2 μM) as a ferroptosis inhibitor reverses the expression trend of these proteins.
Cell Commun Signal

PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy. [Abstract]

2025 May 25;23(1):242. PMID: 40414879
Cell Commun Signal

Protein disulfide isomerase plays a crucial role in mediating chemically-induced, glutathione depletion-associated hepatocyte injury in vitro and in vivo. [Abstract]

2024 Sep 6;22(1):431. PMID: 39243059
Cell Commun Signal

Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]

2024 Jan 18;22(1):53. PMID: 38238728
Cell Commun Signal

The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma. [Abstract]

2020 Oct 28;18(1):174. PMID: 33115468
J Neuroinflammation

THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells. [Abstract]

2025 Feb 24;22(1):48. PMID: 39994679
Phytomedicine

2026 Oct:160:158645. PMID: 42542057
Phytomedicine

2026 Oct:160:158520. PMID: 42542061
Phytomedicine

2026 Oct:160:158611. PMID: 42537468
Phytomedicine

2026 Sep:159:158563. PMID: 42470954
Phytomedicine

Huaier induces lipophagy to promote ferroptosis and chemosensitivity via de-acetylation of PLIN3 in triple-negative breast cancer. [Abstract]

2026 Sep:159:158559. PMID: 42470956
Phytomedicine

2026 Sep:159:158529. PMID: 42391814
Phytomedicine

Patchouli oil and its main component patchouli alcohol inhibit colorectal cancer by activating ectopic olfactory receptor. [Abstract]

2026 Aug:158:158408. PMID: 42287815
Phytomedicine

Chlorella pyrenoidosa-derived extracellular vesicles ameliorate ulcerative colitis through microbiota-mediated AKT/mTOR/ferroptosis pathway. [Abstract]

2026 Jul:156:158199. PMID: 42030800
Phytomedicine

Mollugin induces ferroptosis through dysregulation of iron homeostasis and redox balance in non-small cell lung cancer. [Abstract]

2026 Jul 25:157:158316. PMID: 42241811
Phytomedicine

Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α. [Abstract]

2026 Jun:155:158070. PMID: 41861683
Phytomedicine

Quercetin alleviates liver injury in Wilson's disease by inhibiting ferroptosis. [Abstract]

2026 Jun:155:158155. PMID: 41966025
Phytomedicine

5-O-Methylembelin disrupts the ACO1-TPI1 interaction to promote ferroptosis in clear cell renal cell carcinoma. [Abstract]

2026 May 14:157:158282. PMID: 42166976
Phytomedicine

Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1. [Abstract]

2026 May:154:158040. PMID: 41818942
Phytomedicine

β-mangostin triggers ER stress-mediated mitochondrial dysfunction to induce apoptosis in colorectal cancer. [Abstract]

2026 May 26. PMID: 42275878
Phytomedicine

Apigenin-5-O-glucoside alleviates hepatic fibrosis through NOX4-mediated ferroptosis in zebrafish. [Abstract]

2026 Apr:153:157956. PMID: 41713217
Phytomedicine

Hydroalcoholic gel of Angelica sinensis polysaccharides promotes wound healing by suppressing ferroptosis through PI3K/AKT/Nrf2 signaling pathway. [Abstract]

2026 Apr:153:157962. PMID: 41724102
Phytomedicine

Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway. [Abstract]

2026 Jun:155:158126. PMID: 41931998
Phytomedicine

Concentrated Angelica sinensis pills ameliorate ovarian insufficiency by promoting vascular remodeling via inhibiting CYP1B1/ACSL4-mediated ferroptosis. [Abstract]

2026 May:154:158024. PMID: 41795290
Phytomedicine

Molecular mechanisms of shenhong tongluo formula against myocardial ischemia-reperfusion injury: Insights from RNA sequencing, bioinformatics, reverse network pharmacology, molecular docking, and molecular dynamics simulations combined with experimental studies. [Abstract]

2026 Jun:155:157896. PMID: 41921237
Phytomedicine

Xuebijing injection alleviates sepsis-induced acute lung injury by triggering ferroptosis of CCR2hi monocytes. [Abstract]

2026 Jan:150:157641. PMID: 41365193
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2026 Jan:150:157633. PMID: 41351983
Phytomedicine

Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming. [Abstract]

2026 Mar:152:157884. PMID: 41619549
Phytomedicine

Dehydrocavidine alleviates lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway to inhibit hepatocyte ferroptosis. [Abstract]

2026 Jan 17:153:157845. PMID: 41653616
Phytomedicine

Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways. [Abstract]

2026 Jan:150:157584. PMID: 41349457
Phytomedicine

Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3. [Abstract]

2026 Jan:150:157675. PMID: 41385950
Phytomedicine

Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation. [Abstract]

2026 Jan 20:153:157860. PMID: 41650525
Phytomedicine

Xin-Ji-Er-Kang modulates NRF2 to inhibit ferroptosis and attenuate doxorubicin-induced myocardial injury. [Abstract]

2025 Nov 25:148:157302. PMID: 41056858
Phytomedicine

Andrographolide induces ferroptosis in colorectal cancer via P53-mediated downregulation of the SLC7A11/GPX4 signaling pathway. [Abstract]

2025 Nov 25:148:157470. PMID: 41187650
Phytomedicine

Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO. [Abstract]

2025 Nov:147:157171. PMID: 40839992
Phytomedicine

2',4'-dihydroxychalcone induces ferroptosis through ERO1A/GPX4 regulatory axis in cholangiocarcinoma. [Abstract]

2025 Nov:147:157192. PMID: 40902362
Phytomedicine

Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer. [Abstract]

2025 Oct:146:157117. PMID: 40812220
Phytomedicine

Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury. [Abstract]

2025 Sep:145:157034. PMID: 40617054
Phytomedicine

The protective mechanism of Hydroxysafflor yellow A for the treatment of stroke - heart - syndrome via activating the ZBP1-NLRP3 signaling pathway. [Abstract]

2025 Sep:145:157011. PMID: 40602292
Phytomedicine

Astragali radix - Curcumae rhizoma herb pair enhances Sorafenib's efficacy by inducing ferroptosis and activates Th1 cell immune response synergistically against hepatocellular carcinoma. [Abstract]

2025 Sep 23:148:157326. PMID: 41016296
Phytomedicine

Suppressing ferroptosis via modulating FTH1 by silybin for treatment of renal fibrosis. [Abstract]

2025 Sep:145:156937. PMID: 40541121
Phytomedicine

Synergistic effects of heterophyllin B with nintedanib against experimental pulmonary fibrosis in mice. [Abstract]

2025 Aug:144:156922. PMID: 40513322
Phytomedicine

Ginsenoside Rg5 ameliorates lipopolysaccharide (LPS)-induced acute liver injury via interfering Autophagy/Nrf2/Ferroptosis signal axis. [Abstract]

2025 Aug:144:156941. PMID: 40516288
Phytomedicine

Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis. [Abstract]

2025 Jul 25:143:156925. PMID: 40456202
Phytomedicine

CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis. [Abstract]

2025 Jul 25:143:156911. PMID: 40466505
Phytomedicine

Celastrol attenuates ferroptosis-mediated intestinal ischemia/reperfusion-induced acute lung injury via Hippo-YAP signaling. [Abstract]

2025 Jul 25:143:156865. PMID: 40414049
Phytomedicine

The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis. [Abstract]

2025 Jul:142:156804. PMID: 40311597
Phytomedicine

α-Hederin causes ferroptosis in triple-negative breast cancer through modulating IRF1 to suppress GPX4. [Abstract]

2025 Jun:141:156611. PMID: 40153970
Phytomedicine

Gastrodin targets the system Xc-/GPX4 axis to inhibit abnormal proliferation of fibroblast-like synoviocytes and improve rheumatoid arthritis. [Abstract]

2025 Apr:139:156493. PMID: 39970857
Phytomedicine

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis. [Abstract]

2025 Apr:139:156417. PMID: 39923427
Phytomedicine

Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis. [Abstract]

2025 Feb:137:156362. PMID: 39809030
Phytomedicine

Erianin triggers ferroptosis in colorectal cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2025 Apr:139:156465. PMID: 39938177
Phytomedicine

Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy. [Abstract]

2025 Jan:136:156286. PMID: 39647465
Phytomedicine

Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis. [Abstract]

2024 Dec:135:156095. PMID: 39383632
Phytomedicine

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis. [Abstract]

2024 Dec:135:156139. PMID: 39423479
Phytomedicine

Vinpocetine protects against osteoarthritis by inhibiting ferroptosis and extracellular matrix degradation via activation of the Nrf2/GPX4 pathway. [Abstract]

2024 Dec:135:156115. PMID: 39368343
Phytomedicine

Ginsenoside compound K alleviates brain aging by inhibiting ferroptosis through modulation of the ASK1-MKK7-JNK signaling pathway. [Abstract]

2024 Dec:135:156239. PMID: 39547099
Phytomedicine

β,β-Dimethylacrylalkannin, a key component of Zicao, induces cell cycle arrest and necrosis in hepatocellular carcinoma cells. [Abstract]

2024 Nov:134:155959. PMID: 39178682
Phytomedicine

TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway. [Abstract]

2024 Jul:129:155597. PMID: 38643713
Phytomedicine

Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta. [Abstract]

2024 Jun:128:155423. PMID: 38518646
Phytomedicine

Ethanol extract of Eclipta prostrata induces multiple myeloma ferroptosis via Keap1/Nrf2/HO-1 axis. [Abstract]

2024 Jun:128:155401. PMID: 38507850
Phytomedicine

Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction. [Abstract]

2024 Apr:126:155407. PMID: 38340577
Phytomedicine

Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway. [Abstract]

2024 Mar:125:155342. PMID: 38295665
Phytomedicine

Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel. [Abstract]

2024 Jan:122:155165. PMID: 37922791
Phytomedicine

Timosaponin AIII induces lipid peroxidation and ferroptosis by enhancing Rab7-mediated lipophagy in colorectal cancer cells. [Abstract]

2024 Jan:122:155079. PMID: 37863004
Phytomedicine

Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis. [Abstract]

2023 Jul 25:116:154881. PMID: 37209607
Phytomedicine

Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway. [Abstract]

2023 Jun:114:154748. PMID: 36933519
Phytomedicine

A novel sesquiterpene lactone fraction from Eupatorium chinense L. suppresses hepatocellular carcinoma growth by triggering ferritinophagy and mitochondrial damage. [Abstract]

2023 Apr:112:154671. PMID: 36773432
Phytomedicine

Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. [Abstract]

2023 Jan:109:154593. PMID: 36610113
Phytomedicine

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction. [Abstract]

2023 Jan:109:154601. PMID: 36610134
Phytomedicine

6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species. [Abstract]

2022 May 13;102:154164. PMID: 35597026
Phytomedicine

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. [Abstract]

2021 May:85:153551. PMID: 33827043
J Pharm Anal

2026 Apr 13.
J Pharm Anal

2025 Dec 15.
EBioMedicine

2025 Dec 8;123:106058.
J Pharm Anal

Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6. [Abstract]

2025 May;15(5):101092. PMID: 40496065

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Cell viability of chondrocytes treated with ferroptosis inducers ((1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1,10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1, 1 μM) for 24 h was detected by Cell Counting Kit-8 (CCK-8).

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Bright-field and fluorescent images of live/dead staining of chondrocytes treated with ferroptosis inducers (1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h. Propidium iodide (PI) stained (Red) for dead cells, and Calcein-AM (Green) stained for live cells.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

The protein levels of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by Western blotting assay

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

The mRNA levels of catabolic enzymes (Mmp13 and Adamts4) and matrix components (Col2a1 and Acan) in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by RT-qPCR.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Immunofluorescence of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Representative images of H&E, safranin O fast green and toluidine blue staining of cartilage sections of mice injected intraarticularly with VK1 (1 mg/kg, DMM + VK1 + AAV-NC and DMM + VK1 + AAV-shGas6 groups), Ferrostatin-1 (Fer-1; 0.1 mg/kg, DMM + Fer-1 + AAV-NC group) or vehicle (Sham + AAV-NC and DMM + AAV-NC groups) twice a week for two weeks.
J Pharm Anal

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52. [Abstract]

2024 Jan;14(1):86-99. PMID: 38352945
J Pharm Anal

Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor. [Abstract]

2023 Jan;13(1):99-109. PMID: 36816538
EBioMedicine

Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression. [Abstract]

2022 Feb;76:103847. PMID: 35101656

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Feb;76:103847. [Abstract]

Mitochondrial membrane potential (ΔΨm) measured by fluorescence microscopy of MCC treated with TBHP and rescued via Ferrostatin-1 (Fer-1; 1 μM) using JC-1 Mitochondrial Membrane Potential Assay. In Fer-1 and DFO group, red fluorescence (poly JC-1) is increased and green fluorescence (mono JC-1) is decreased.
EBioMedicine

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. [Abstract]

2021 Jul;69:103456. PMID: 34233258
Burns Trauma

2026 Jul 6.
Mater Today Bio

2026 Jul 22:40:103486. PMID: 42576909
Mater Today Bio

NIR-elicited nanoplatform amplifies cancer ferrotherapy in uveal melanoma via synergistic ferroptosis induction and glucose metabolism intervention. [Abstract]

2026 May 6:38:103208. PMID: 42170235
Mater Today Bio

Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway. [Abstract]

2026 Apr 10:38:103113. PMID: 42028284
Adv Healthc Mater

Biomimetic Copper-Doped Nano-Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia. [Abstract]

2026 Mar 10:e04039. PMID: 41804653
Mater Today Bio

Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system. [Abstract]

2026 Feb 23:37:102965. PMID: 41800454
Mater Today Bio

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse. [Abstract]

2025 Nov 13:35:102547. PMID: 41322137
Adv Healthc Mater

Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression. [Abstract]

2025 Sep 13:e02489. PMID: 40944582
Mater Today Bio

Injectable magnetic hydrogel induces multi-programmed cell death and deep tumor regression in magnetic hyperthermia therapy in hepatocellular carcinoma. [Abstract]

2025 Sep 25:35:102341. PMID: 41089724
Adv Healthc Mater

Engineering Iridium Nanoclusters for Boosting Ferroptotic Cell Death by Regulating GPX4 and p53 Functions. [Abstract]

2025 Apr;14(10):e2404895. PMID: 40018815
Mater Today Bio

IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. [Abstract]

2022 Nov 24:17:100503. PMID: 36457846
Arch Toxicol

Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis. [Abstract]

2024 Oct;98(10):3323-3336. PMID: 38896176
Arch Toxicol

The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice. [Abstract]

2024 Jun;98(6):1781-1794. PMID: 38573338
J Hazard Mater

2026 Aug 1:514:142882. PMID: 42407312
J Hazard Mater

HFPO-TA inhibits testosterone synthesis by triggering FTO-mediated m6A modification to drive NCOA4-associated ferroptosis. [Abstract]

2026 Jun 16:514:142733. PMID: 42314315
J Hazard Mater

Polystyrene microplastics disrupt the blood-testis barrier via CEBPB-driven lysosomal autophagy and induce ferroptosis-like injury in human sperm, compromising embryo development. [Abstract]

2026 Jun 1:510:142073. PMID: 42000504
J Hazard Mater

A translational in vitro to in vivo study on chronic arsenic exposure induced pulmonary ferroptosis and multi-omics analysis of gut-lung axis correlation. [Abstract]

2025 Sep 5:495:139049. PMID: 40614423
J Hazard Mater

Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach. [Abstract]

2024 Dec 5:480:135814. PMID: 39303606
J Hazard Mater

The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis. [Abstract]

2024 Oct 5:478:135580. PMID: 39186845
Part Fibre Toxicol

Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage. [Abstract]

2024 Mar 7;21(1):13. PMID: 38454452
J Hazard Mater

BDE-47 induced PC-12 cell differentiation via TrkA downstream pathways and caused the loss of hippocampal neurons in BALB/c mice. [Abstract]

2022 Jan 15;422:126850. PMID: 34419847
Cell Death Discov

2026 Jul 22. PMID: 42481442
Cell Death Discov

The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway. [Abstract]

2026 Feb 25;12(1):111. PMID: 41741409
Cell Death Discov

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation. [Abstract]

2026 Jan 9;12(1):12. PMID: 41513631
Cell Death Discov

SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer. [Abstract]

2025 Oct 7;11(1):447. PMID: 41057306
Cell Death Discov

Metabolic interplay between exogenous cystine and glutamine dependence in triple-negative breast cancer. [Abstract]

2025 Oct 6;11(1):430. PMID: 41053011
Cell Death Discov

ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer. [Abstract]

2025 Aug 22;11(1):398. PMID: 40846695
Cell Death Discov

Inhibition of ferroptosis in inflammatory macrophages alleviates intestinal injury in neonatal necrotizing enterocolitis. [Abstract]

2025 Aug 5;11(1):365. PMID: 40764334
Acta Biomater

A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment. [Abstract]

2025 Aug:202:463-475. PMID: 40618974
Cell Death Discov

Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury. [Abstract]

2025 Jul 1;11(1):290. PMID: 40595455
Cell Death Discov

Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer. [Abstract]

2025 Apr 4;11(1):139. PMID: 40180904
Cell Death Discov

Decreased miR-128-3p in serum exosomes from polycystic ovary syndrome induces ferroptosis in granulosa cells via the p38/JNK/SLC7A11 axis through targeting CSF1. [Abstract]

2025 Feb 18;11(1):64. PMID: 39966422
Acta Pharmacol Sin

Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2024 Aug;45(8):1673-1685. PMID: 38641746
Acta Pharmacol Sin

SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer. [Abstract]

2024 Apr;45(4):844-856. PMID: 38057506
Cell Death Discov

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. [Abstract]

2024 Mar 12;10(1):134. PMID: 38472168
Cell Death Discov

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. [Abstract]

2024 Jan 17;10(1):34. PMID: 38233385

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Jan 17;10(1):34. [Abstract]

After pretreatment with Fer-1 (10 μM), Lip-1 (2 μM), or DFO (10 μM) for 1 hour, the cells were treated with GLU or NMDA (1 mM) for 24 hours, and then flow cytometry was performed.
Cell Death Discov

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer. [Abstract]

2024 Jan 23;10(1):42. PMID: 38263152
Cell Death Discov

SCARB1 in extracellular vesicles promotes NPC metastasis by co-regulating M1 and M2 macrophage function. [Abstract]

2023 Aug 29;9(1):323. PMID: 37644041
Cell Death Discov

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis. [Abstract]

2023 Aug 15;9(1):297. PMID: 37582760
Cell Death Discov

Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. [Abstract]

2023 Aug 14;9(1):296. PMID: 37580343
Cell Death Discov

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. [Abstract]

2023 Aug 25;9(1):311. PMID: 37626043
Acta Pharmacol Sin

Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma. [Abstract]

2023 Mar;44(3):622-634. PMID: 36109580
Cell Death Discov

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis. [Abstract]

2021 Dec 4;7(1):374. PMID: 34864819
Acta Pharmacol Sin

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Feb;42(2):301-310. PMID: 32699265
Acta Pharmacol Sin

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2021 Jan;42(1):160-170. PMID: 32541921
Environ Int

Trimethyltin chloride triggers ferroptosis in myocardial injury: mitochondria-dependent protection by luteolin. [Abstract]

2026 May:211:110262. PMID: 42013553
Environ Int

Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis. [Abstract]

2025 Aug:202:109706. PMID: 40749542
NPJ Precis Oncol

SPOCK1 acts as a negative regulator of ferroptosis in non-small cell lung cancer. [Abstract]

2026 May 14. PMID: 42135411
NPJ Precis Oncol

M6A-ALKBH5-dependent RBMS3-AS3 down-regulation suppresses ferroptosis to promote lung adenocarcinoma progression through HNRNPDL/ZEB1/GPX4 axis. [Abstract]

2025 Nov 17;9(1):356. PMID: 41249383
NPJ Precis Oncol

Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLC. [Abstract]

2024 Aug 21;8(1):183. PMID: 39169204
Sci China Chem

2025 Jun 30.
J Orthop Translat

SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound. [Abstract]

2025 Apr 25:52:233-248. PMID: 40337549
NPJ Sci Food

Lycopene mitigates T-2 toxin-induced hepatic ferroptosis by targeting the Nrf2/mitophagy axis in mice. [Abstract]

2026 Feb 7;10(1):94. PMID: 41654705
J Transl Med

Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma. [Abstract]

2025 Sep 24;23(1):1011. PMID: 40993737
J Transl Med

Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression. [Abstract]

2025 Apr 15;23(1):442. PMID: 40234906
J Transl Med

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis. [Abstract]

2025 Feb 28;23(1):247. PMID: 40022222
J Transl Med

Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis. [Abstract]

2025 Jan 8;23(1):30. PMID: 39780143
J Colloid Interface Sci

Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy. [Abstract]

2025 Jun 15:688:44-58. PMID: 39987840
Sci China Life Sci

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis. [Abstract]

2025 Jan;68(1):204-218. PMID: 39245684
J Colloid Interface Sci

Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx. [Abstract]

2024 Aug:667:91-100. PMID: 38621335
Sci China Life Sci

Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure. [Abstract]

2024 Feb;67(2):360-378. PMID: 37815699
J Colloid Interface Sci

Interfacial strong interaction-enabling cascade nanozymes for apoptosis-ferroptosis synergistic therapy. [Abstract]

2024 Jan;653(Pt A):20-29. PMID: 37708728
Sci China Life Sci

Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis. [Abstract]

2023 Aug;66(8):1800-1817. PMID: 36949229
Proc Natl Acad Sci U S A

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. [Abstract]

2025 Dec 9;122(49):e2515641122. PMID: 41348733
Proc Natl Acad Sci U S A

HOIP modulates the stability of GPx4 by linear ubiquitination. [Abstract]

2022 Nov;119(44):e2214227119. PMID: 36279464
Nano Res

2026.
Nano Res

2023 Apr 18.
Diabetes

Cooperative Action of Cathepsin K Inhibitor and hUMSC-EVs in Attenuating Ferroptosis Sensitivity for Superior Diabetic Wound Healing. [Abstract]

2026 Jun 1;75(6):1007-1023. PMID: 41979994
Dev Cell

Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma. [Abstract]

2025 Mar 20:S1534-5807(25)00121-2. PMID: 40132584
Dev Cell

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]

2024 Oct 7;59(19):2643-2658.e7. PMID: 38981469
Dev Cell

A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis. [Abstract]

2024 Feb 26;59(4):517-528.e3. PMID: 38272028
CCS Chem

20 Jul 2021.
Oncogene

2026 Jul 4. PMID: 42401760
Chin Med J (Engl)

Inhibitory effect of blestriarene C on triple-negative breast cancer: Inducing ferroptosis and mitophagy via SESN2/AKT/FOXO4 axis. [Abstract]

2026 Mar 5;139(5):699-709. PMID: 41527177
Oncogene

Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma. [Abstract]

2025 Sep;44(34):3142-3148. PMID: 40781157
Oncogene

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]

2025 Jun;44(22):1678-1693. PMID: 40089640
Oncogene

SGK1 suppresses ferroptosis in ovarian cancer via NRF2-dependent and -independent pathways. [Abstract]

2024 Nov;43(45):3335-3347. PMID: 39306614
Apoptosis

2026 Jul 1;31(7):181. PMID: 42384133
Apoptosis

Zinc regulates the balance of specific gut microbiota through MTF1/Nrf2 and mitigates ferroptosis through activation of PINK1/Parkin/mitophagy via the gut-kidney axis in sepsis-associated acute kidney injury in pregnant mice. [Abstract]

2026 Jun 16;31(7):171. PMID: 42301500
Apoptosis

Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway. [Abstract]

2026 May 24;31(6):156. PMID: 42178429
Apoptosis

QD394 induces ferroptosis and suppresses the proliferation of colorectal cancer via the SP1/JNK pathway. [Abstract]

2026 May 6;31(5):133. PMID: 42090009
Apoptosis

Copper modulates cell fate through the PLK1-FOXO3a-β-catenin signaling pathway by differentially regulating cuproptosis and EMT. [Abstract]

2026 Jan 10;31(1):12. PMID: 41518407
Apoptosis

Mechanism of the enterobacterial metabolite sodium butyrate mediating ferroptosis to affect osteogenic ability of BMSCs in mice with estrogen deficiency-caused osteoporosis via the PTEN/PI3K/AKT pathway. [Abstract]

2025 Dec;30(11-12):3087-3104. PMID: 41205030
Int J Surg

Ferroptosis is involved in the IL-9-induced intestinal barrier injury in sepsis: an experimental animal and translational study. [Abstract]

2025 Jul 1;111(7):4314-4324. PMID: 40391960
Apoptosis

The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome. [Abstract]

2024 Dec 3. PMID: 39627575
Apoptosis

Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation. [Abstract]

2024 Oct;29(9-10):1810-1823. PMID: 38704789
Small Methods

2026 Aug;10(15):e70859. PMID: 42458865
Int J Biol Macromol

Ganoderma lucidum polysaccharides alleviate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through modulation of the Nrf2/SLC7A11/GPX4 signaling pathway. [Abstract]

2026 Jun:367:152584. PMID: 42155741
Int J Biol Macromol

Pharmacological activation of HSF1 by HSF1A mitigates heatstroke-induced acute kidney injury via ferroptosis inhibition. [Abstract]

2026 May:360:151803. PMID: 41937010
Int J Biol Macromol

Emodin exerts antitumor effects in cervical cancer cells by reprogramming phospholipid metabolism through modulation of H3K27ac and H3K27me3. [Abstract]

2026 Apr:357:151454. PMID: 41856179
Int J Biol Macromol

ETS transcription factor 1-insulin-like growth factor 2 mRNA-binding protein 2-interferon-induced transmembrane protein 3 pathway promotes ferroptosis-driven osteoblast senescence in diabetic osteoporosis. [Abstract]

2026 Mar:350:150917. PMID: 41692190
Int J Biol Macromol

S100A4 regulates ferroptosis to suppress cell proliferation via the SLC7A11-GSH axis but facilitates Brucella infection in RAW264.7 macrophages. [Abstract]

2025 Dec;333(Pt 1):148831. PMID: 41203174
Int J Biol Macromol

Rbbp7-mediated deacetylation of Acsl4 promotes ovarian aging by enhancing ferroptosis. [Abstract]

2025 Dec 30;339(Pt 2):149976. PMID: 41478474
Int J Nanomedicine

GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress. [Abstract]

2025 Nov 24:20:14033-14055. PMID: 41321900
Int J Biol Macromol

Light-crosslinked gelatin methacrylate hydrogel prevents intervertebral disc degeneration by delivering 10-hydroxy-2-decenoic acid to inhibit ferroptosis via NF-κB signaling. [Abstract]

2025 Oct 21;331(Pt 2):148454. PMID: 41130468
Int J Biol Macromol

SPINT2 inhibits NEDD4L-mediated ACSL4 ubiquitination to promote ferroptosis and suppress gallbladder cancer progression. [Abstract]

2025 Oct 9;330(Pt 3):148141. PMID: 41067336
Int J Biol Macromol

Pleurotus citrinopileatus polysaccharides ameliorate DSS-induced ulcerative colitis by improving intestinal barrier and inflammation modulation via NF-κB pathway. [Abstract]

2025 Sep 4;327(Pt 2):147256. PMID: 40914366
Int J Biol Macromol

Heme oxygenase-1 (HO-1) depletion promotes ferroptosis to reverse cisplatin-resistance via enhancing NCOA4-mediated ferritinophagy in ovarian cancer. [Abstract]

2025 Sep 2;327(Pt 2):147257. PMID: 40907917
Int J Nanomedicine

Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing. [Abstract]

2025 Aug 6:20:9753-9770. PMID: 40791776
Int J Biol Macromol

Molecular mechanisms underlying the anti-Colon Cancer effects of Caulerpa lentillifera polysaccharides (CLP). [Abstract]

2025 May;308(Pt 4):142594. PMID: 40157667
Int J Biol Macromol

Mechanism of UHRF1 protein macromolecule regulating ferroptosis in liver cancer: inhibition of GSTZ1 expression through DNA methylation. [Abstract]

2025 May 8;311(Pt 4):144060. PMID: 40348248
Int J Nanomedicine

Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro. [Abstract]

2025 Apr 2:20:4035-4050. PMID: 40191047
Int J Nanomedicine

Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma. [Abstract]

2025 Mar 10:20:2901-2921. PMID: 40093542
Int J Biol Macromol

Poly-l-arginine promotes ferroptosis in asthmatic airway epithelial cells by modulating PBX1/GABARAPL1 axis. [Abstract]

2025 Jan:286:138478. PMID: 39645127
Int J Biol Macromol

Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2/GPX4 pathway. [Abstract]

2024 Sep;276(Pt 1):133792. PMID: 38992539
Int J Nanomedicine

A pH-Responsive Drug-Delivery System Based on Apatinib-Loaded Metal-Organic Frameworks for Ferroptosis-Targeted Synergistic Anti-Tumor Therapy. [Abstract]

2024 Sep 4:19:9055-9070. PMID: 39246426
JHEP Rep

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling. [Abstract]

2023 Feb 3;5(5):100695. PMID: 36968217
Int J Nanomedicine

p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides. [Abstract]

2021 Jan 12:16:283-296. PMID: 33469287
Int J Mol Med

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway. [Abstract]

2026 May;57(5):117. PMID: 41823538
Int J Mol Med

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer. [Abstract]

2026 Jan;57(1):4. PMID: 41133455
Neural Regen Res

TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury. [Abstract]

2025 Sep 3. PMID: 40903977
Int J Mol Med

Curcumenol inhibits malignant progression and promotes ferroptosis via the SLC7A11/NF‑κB/TGF‑β pathway in triple‑negative breast cancer. [Abstract]

2025 Jul;56(1):111. PMID: 40377003
Int J Mol Med

Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. [Abstract]

2024 Dec;54(6):110. PMID: 39364745
JACS Au

DefNEtTrp: An Iron Dual Chelator Approach for Anticancer Application. [Abstract]

2024 Dec 4;4(12):4799-4808. PMID: 39735911
Int J Mol Med

New insight for SS‑31 in treating diabetic cardiomyopathy: Activation of mitoGPX4 and alleviation of mitochondria‑dependent ferroptosis. [Abstract]

2024 Dec;54(6):112. PMID: 39364755
Int J Mol Med

Copper supplementation alleviates hypoxia‑induced ferroptosis and oxidative stress in neuronal cells. [Abstract]

2024 Dec;54(6):117. PMID: 39422051
Int J Mol Med

Unveiling the role of RhoA and ferroptosis in vascular permeability: Implications for osteoarthritis. [Abstract]

2024 Oct;54(4):86. PMID: 39129277
Neural Regen Res

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1. [Abstract]

2024 Jul 1;19(7):1568-1574. PMID: 38051901
Int J Mol Med

Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1. [Abstract]

2023 Nov;52(5):109. PMID: 37800609
Int J Mol Med

Metabolic heterogeneity protects metastatic mucosal melanomas cells from ferroptosis. [Abstract]

2022 Oct;50(4):124. PMID: 36004461
Int J Mol Med

Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway. [Abstract]

2022 Jul;50(1):89. PMID: 35582998
Int J Mol Med

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. [Abstract]

2021 Apr;47(4):61. PMID: 33649797
EMBO J

Stearate-derived very long-chain fatty acids are indispensable to tumor growth. [Abstract]

2023 Jan 16;42(2):e111268. PMID: 36408830
Mol Med

The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts. [Abstract]

2025 Oct 21;31(1):315. PMID: 41120907
Mol Med

Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy. [Abstract]

2025 Jul 24;31(1):264. PMID: 40702453
Mol Med

MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis. [Abstract]

2024 Nov 5;30(1):199. PMID: 39501138
Mol Med

CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer. [Abstract]

2024 Nov 15;30(1):219. PMID: 39548421
Sens Actuators B Chem

2024 Nov 1.
Sens Actuators B Chem

2024 Jan 15, 399, 134872.
Mol Med

Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis. [Abstract]

2023 Sep 28;29(1):132. PMID: 37770820
Sens Actuators B Chem

15 December 2022, 132707.
Antioxidants (Basel)

2026 Jul 19;15(7):891. PMID: 42510622
Antioxidants (Basel)

2026 Jul 14;15(7):876. PMID: 42510607
Antioxidants (Basel)

Gut Microbiota-Mediated Histidine Deficiency Drives Testicular Ferroptosis Induced by Bisphenol F Exposure. [Abstract]

2026 Jun 4;15(6):714. PMID: 42352020
Antioxidants (Basel)

Spermidine Targets Ovarian Granulosa Cells via Activating the FHC/SLC7A11 Axis to Regulate Iron Homeostasis and Ameliorate Iron Overload-Induced Ovarian Dysfunction. [Abstract]

2026 May 18;15(5):637. PMID: 42193258
Antioxidants (Basel)

Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis. [Abstract]

2026 Apr 14;15(4):484. PMID: 42072126
Antioxidants (Basel)

Aspirin Eugenol Ester Alleviates Gastric Injury by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Feb 9;15(2):225. PMID: 41750606
Arch Pharm Res

JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity. [Abstract]

2026 Feb;49(2):223-241. PMID: 41723769
Antioxidants (Basel)

Aspirin Eugenol Ester Alleviates Vascular Endothelial Ferroptosis by Enhancing Antioxidant Ability and Inhibiting the JNK/c-Jun/NCOA4/FTH Signaling Pathway. [Abstract]

2025 Oct 10;14(10):1220. PMID: 41154529
Environ Res

Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis. [Abstract]

2024 Oct 1:258:119483. PMID: 38914254
Environ Res

Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts. [Abstract]

2024 Oct 2;263(Pt 2):120098. PMID: 39366441
Antioxidants (Basel)

Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway. [Abstract]

2024 Jan 23;13(2):140. PMID: 38397738
Antioxidants (Basel)

PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis. [Abstract]

2023 Dec 19;13(1):3. PMID: 38275623
Antioxidants (Basel)

Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53-Mediated Ferroptosis. [Abstract]

2023 May 29;12(6):1173. PMID: 37371903
Phytother Res

Z-Guggulsterone Induces Ferroptosis in Chemoresistant Breast Cancer via a CDKN2B-Mediated Suppression of GTP Cyclohydrolase 1. [Abstract]

2026 Jun;40(6):3704-3721. PMID: 41952325
Phytother Res

Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction. [Abstract]

2026 Jun 22. PMID: 42333683
Phytother Res

Daphnetin Alleviates Liver Fibrosis by Inducing Ferritinophagy-Mediated Ferroptosis in Activated Hepatic Stellate Cells. [Abstract]

2025 Dec 5. PMID: 41351245
Phytother Res

Sepsis-Induced Liver Injury Mitigated by Isoferulic Acid Through Inhibition of Hepatic Ferroptosis via the SIRT1 Signaling Pathway. [Abstract]

2025 Sep 18. PMID: 40968354
Phytother Res

4'-Hydroxychalcone Induces Ferroptosis in Glioblastoma Through the xCT/GSH/GPX4 Axis Under the Regulation of the AKT/mTORC1/4EBP1 Pathway. [Abstract]

2025 Aug 25. PMID: 40855403
Phytother Res

l-Theanine Improves Learning and Memory Through Attenuation of NOX4-Mediated Ferroptosis in Hippocampal Neurons of Sleep-Deprived Mice. [Abstract]

2025 Jul 19. PMID: 40682446
VIEW

2025 May 25.
Phytother Res

Platycodin D2 Mediates Incomplete Autophagy and Ferroptosis in Breast Cancer Cells by Regulating Mitochondrial ROS. [Abstract]

2025 Feb;39(2):581-592. PMID: 39581858
Phytother Res

Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma. [Abstract]

2024 Dec;38(12):5583-5597. PMID: 39293861
Phytother Res

Delay the progression of glucocorticoid-induced osteoporosis: Fraxin targets ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2024 Nov;38(11):5203-5224. PMID: 39192711
Free Radic Biol Med

Rab26 mitigates ferroptosis in airway epithelium induced by cigarette smoke through suppression of VDAC1 oligomerization-mediated cGAS-STING activation. [Abstract]

2026 Sep:253:177-194. PMID: 42176907
Free Radic Biol Med

Raddeanin A induces ferroptosis by targeting VEPH1 in a cisplatin-resistant epithelial ovarian cancer cell line. [Abstract]

2026 Aug 16:252:55-68. PMID: 41997548
Free Radic Biol Med

Macrophage TRPML1 ameliorates post-myocardial infarction inflammation by blocking VDAC1 oligomerization to prevent ferroptosis and cGAS-STING activation. [Abstract]

2026 Aug 16:252:166-183. PMID: 42092410
Free Radic Biol Med

DLAT sustains redox homeostasis and prevent colorectal cancer from ferroptosis by regulating SLC25A39-mediated mitochondrial glutathione transport. [Abstract]

2026 Aug 1:251:229-242. PMID: 42009144
Free Radic Biol Med

Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis. [Abstract]

2026 Jul:250:284-297. PMID: 41933740
Free Radic Biol Med

2026 Jul 16:255:194-205. PMID: 42462913
Free Radic Biol Med

Repurposing the hERG activator NS-1643 as a ferroptosis-targeting therapeutic against doxorubicin cardiotoxicity. [Abstract]

2026 Jun:249:14-26. PMID: 41794151
Free Radic Biol Med

Stabilization of Keap1 by alkannin triggers ferroptotic cell death in colorectal cancer via suppression of the Nrf2/GPX4 signaling. [Abstract]

2026 Jun 23:254:342-359. PMID: 42336003
Free Radic Biol Med

PARS2 deficiency impairs mitochondrial homeostasis and activates ferroptotic to drive developmental and epileptic encephalopathy. [Abstract]

2026 Jun 7:254:307-322. PMID: 42259431
Free Radic Biol Med

Stabilization of β-catenin by 7,8-Dihydroxyflavone protects against osteoblast ferroptosis and bone loss in type 2 diabetic osteoporosis. [Abstract]

2026 May 16:252:541-558. PMID: 42144026
Free Radic Biol Med

Tartrate-Resistant Acid Phosphatase 5 (TRAP/ACP5) aggravates atherosclerosis by regulating macrophage polarization and promoting ferroptosis. [Abstract]

2026 Apr:247:486-501. PMID: 41692316
Free Radic Biol Med

Chronic intermittent cold stress-induced lipophagy promotes foamy macrophage susceptibility to ferroptosis and exacerbates atherosclerosis. [Abstract]

2026 Jan:242:636-653. PMID: 41205774
Free Radic Biol Med

Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]

2026 Mar 16:246:35-50. PMID: 41520847
Free Radic Biol Med

Inhibiting Arachidonate-5-lipoxygenase expression ameliorates osteoarthritis progression by suppressing ferroptosis via the JAK2/STAT3 signaling pathway. [Abstract]

2026 Mar 16:246:334-349. PMID: 41581577
Free Radic Biol Med

Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation. [Abstract]

2025 Dec 15:244:284-295. PMID: 41407052
Free Radic Biol Med

Baicalin triggers ferroptosis to suppress colorectal cancer via SLC25A28-UQCRC2-regulated electron transport chain disruption. [Abstract]

2025 Dec 26:245:56-70. PMID: 41456814
Free Radic Biol Med

The MafG/Bach1-Lcn2 transcriptional axis drives ferroptosis in sepsis-induced acute lung injury via disrupting redox homeostasis. [Abstract]

2025 Dec 29:245:250-268. PMID: 41475687
Free Radic Biol Med

Exosomal CagA induces macrophage polarization and ferroptosis by JAK1-2/STAT1 signaling pathway in Helicobacter pylori-associated gastritis. [Abstract]

2025 Nov:239:91-103. PMID: 40706822
Free Radic Biol Med

Reticulon 3 deficiency induces ferroptosis via chaperone-mediated autophagy in ischemia-reperfusion induced acute kidney injury. [Abstract]

2025 Oct 10:242:9-20. PMID: 41077100
Free Radic Biol Med

NADPH oxidase-dependent heme oxygenase-1 expression mediates cigarette smoke-induced ferroptosis via intracellular Fe(II) accumulation. [Abstract]

2025 Sep:237:131-146. PMID: 40456495
Free Radic Biol Med

siHIF-1α-loaded micellar nanoparticles inhibit M1 macrophage activation to ameliorate chronic rhinosinusitis. [Abstract]

2025 Sep:237:403-418. PMID: 40456494
Free Radic Biol Med

Neutrophil extracellular traps induce fibroblast ferroptosis via IRE1α/XBP1-mediated ER stress to impair diabetic wound healing. [Abstract]

2025 Aug 16:236:17-27. PMID: 40379156
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: Insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis. [Abstract]

2025 Aug 9:240:267-283. PMID: 40789497
Free Radic Biol Med

FATP5 deficiency alleviates MASH via remodeling hepatic lipid composition to suppress ferroptosis. [Abstract]

2025 Aug 19:240:170-182. PMID: 40840619
Free Radic Biol Med

Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING. [Abstract]

2025 Aug 20:240:373-383. PMID: 40846100
Free Radic Biol Med

Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway. [Abstract]

2025 Aug 11:240:238-252. PMID: 40803417
Free Radic Biol Med

The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism. [Abstract]

2025 May:232:97-106. PMID: 40032029
Free Radic Biol Med

Role of ferroptosis mediated by abnormal membrane structure in DEHP-induced reproductive injury. [Abstract]

2025 Apr 28:235:150-161. PMID: 40306442
Free Radic Biol Med

S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis. [Abstract]

2025 Mar 16:230:112-126. PMID: 39947495
Free Radic Biol Med

Triptolide alleviates acute lung injury by reducing mitochondrial dysfunction mediated ferroptosis through the STAT3/p53 pathway. [Abstract]

2025 Mar 16:230:79-94. PMID: 39914683
Free Radic Biol Med

Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]

2025 Feb 16:228:173-182. PMID: 39761766
Free Radic Biol Med

HO-1-mediated ferroptosis regulates retinal neovascularization via the COX2/VEGFA axis. [Abstract]

2025 Jan:226:84-95. PMID: 39542186
Free Radic Biol Med

Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury. [Abstract]

2024 Dec 9:227:296-311. PMID: 39653130
Free Radic Biol Med

Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis. [Abstract]

2024 Nov 6:226:13-28. PMID: 39510452
Free Radic Biol Med

Novel therapeutic approach for psoriasis: Upregulating FcRn to inhibit ferroptosis and alleviate lesional skin. [Abstract]

2024 Nov 1:224:797-808. PMID: 39270944
Free Radic Biol Med

Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma. [Abstract]

2024 Nov 1:224:310-324. PMID: 39216560
Free Radic Biol Med

Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis. [Abstract]

2024 Nov 1:224:272-286. PMID: 39216559
Free Radic Biol Med

LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction. [Abstract]

2024 Nov 8:226:29-42. PMID: 39522565
Free Radic Biol Med

LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis. [Abstract]

2024 Oct:223:42-52. PMID: 39033829
Free Radic Biol Med

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis. [Abstract]

2024 Sep:222:344-360. PMID: 38945457
Free Radic Biol Med

Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1. [Abstract]

2024 Aug 1:220:139-153. PMID: 38705495
Free Radic Biol Med

Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury. [Abstract]

2024 Jul:219:215-230. PMID: 38636715
Free Radic Biol Med

Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury. [Abstract]

2024 Jun:218:120-131. PMID: 38583680
Free Radic Biol Med

Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice. [Abstract]

2024 May 9:221:1-12. PMID: 38734270
Free Radic Biol Med

Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy. [Abstract]

2024 May 1:217:1-14. PMID: 38522484
Free Radic Biol Med

Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction. [Abstract]

2024 Mar:214:193-205. PMID: 38369075
Free Radic Biol Med

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]

2024 Mar:213:150-163. PMID: 38190923
Free Radic Biol Med

Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion. [Abstract]

2024 Mar:214:115-128. PMID: 38331008
Free Radic Biol Med

Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma. [Abstract]

2024 Mar:213:512-522. PMID: 38301975
Free Radic Biol Med

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis. [Abstract]

2023 Dec 14:211:127-144. PMID: 38103660
Free Radic Biol Med

Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression. [Abstract]

2023 Nov 1:208:530-544. PMID: 37717793
Free Radic Biol Med

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]

2023 Jul:203:86-101. PMID: 37044150
Free Radic Biol Med

The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity. [Abstract]

2023 May 1:200:26-35. PMID: 36893944
Free Radic Biol Med

Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. [Abstract]

2023 May 20:201:76-88. PMID: 36933812
Free Radic Biol Med

STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice. [Abstract]

2023 May 20:201:111-125. PMID: 36940731
Free Radic Biol Med

Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy. [Abstract]

2023 Feb 1:195:329-342. PMID: 36610561
Free Radic Biol Med

VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis. [Abstract]

2022 Nov 20;193(Pt 2):720-735. PMID: 36402439
Free Radic Biol Med

IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis. [Abstract]

2022 Nov 20;193(Pt 2):579-594. PMID: 36356714
Free Radic Biol Med

Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase. [Abstract]

2022 Nov 20;193(Pt 1):202-212. PMID: 36228830
Free Radic Biol Med

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling. [Abstract]

2022 Nov 3;193(Pt 1):459-473. PMID: 36334846
Free Radic Biol Med

Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling. [Abstract]

2022 Nov 20;193(Pt 1):108-121. PMID: 36241072
Free Radic Biol Med

Sequestered SQSTM1/p62 crosstalk with Keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis. [Abstract]

2022 Sep:190:62-74. PMID: 35940517
Free Radic Biol Med

Macrophages induce cardiomyocyte ferroptosis via mitochondrial transfer. [Abstract]

2022 Sep:190:1-14. PMID: 35933052
Free Radic Biol Med

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation. [Abstract]

2022 Aug 1:188:337-350. PMID: 35752374
Free Radic Biol Med

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2022 Feb 20:180:75-84. PMID: 35038550
Free Radic Biol Med

Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. [Abstract]

2022 Feb 20:180:198-209. PMID: 35063650
Free Radic Biol Med

A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. [Abstract]

2022 Jan:178:271-294. PMID: 34883251
Free Radic Biol Med

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. [Abstract]

2021 Jun:169:271-282. PMID: 33895289
Free Radic Biol Med

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. [Abstract]

2020 Nov 20:160:303-318. PMID: 32846217
Free Radic Biol Med

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. [Abstract]

2020 Nov 20:160:92-102. PMID: 32768568
Free Radic Biol Med

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease. [Abstract]

2020 May 20:152:227-234. PMID: 32217194
Clin Transl Med

USP43-mediated deubiquitination of SLC7A11 protects against LPS-induced acute lung injury by inhibiting ferroptosis. [Abstract]

2026 Jul;16(7):e70718. PMID: 42381269
Clin Transl Med

β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1. [Abstract]

2025 Sep;15(9):e70438. PMID: 40866937
EMBO Mol Med

Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML. [Abstract]

2025 Aug 29. PMID: 40883610
Clin Transl Med

Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4. [Abstract]

2025 Feb;15(2):e70221. PMID: 39902679
J Anim Sci Biotechnol

Quercetin mitigates iron-induced cell death in chicken granulosa cell. [Abstract]

2024 Dec 8;15(1):168. PMID: 39645563
Clin Transl Med

Selective cargo sorting in stem cell-derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration. [Abstract]

2023 Dec;13(12):e1494. PMID: 38037469
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
Clin Transl Med

Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1-Wnt/β-catenin-TFE3 feedback loop signalling. [Abstract]

2022 Apr;12(4):e752. PMID: 35485210
Br J Cancer

2026 Jul 2. PMID: 42393460
Am J Chin Med

Andrographolide Suppresses Head and Neck Squamous Cell Carcinoma Progression via EGR1-ACSL4 Axis-Mediated Ferroptosis. [Abstract]

2026;54(4):1309-1330. PMID: 42252950
ACS Appl Mater Interfaces

Nanoparticle-Based Mitochondrial Disruptor Drives Tumor-Selective Pyroptosis for Effective Colorectal Cancer Immunotherapy. [Abstract]

2026 Jun 24;18(24):33542-33558. PMID: 42273718
ACS Appl Mater Interfaces

ROS-Responsive Hydrogel Delivering Bio-Nanoselenium for Targeted Therapy of UVB-Induced Skin Photodamage. [Abstract]

2026 Apr 29;18(16):22798-22819. PMID: 41983715
Am J Chin Med

Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation. [Abstract]

2026;54(1):329-348. PMID: 41684093
Am J Chin Med

Nobiletin Ameliorated the Development of Diabetic Kidney Disease via Modulating Ferroptosis and Epithelial-Mesenchymal Transition Involving Gut-Kidney Axis. [Abstract]

2026;54(1):303-328. PMID: 41582083
ACS Appl Mater Interfaces

Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment. [Abstract]

2025 Dec 17;17(50):67595-67608. PMID: 41348354
Am J Chin Med

Unraveling the Mechanisms of Active Saponins from Rhizoma Anemarrhenae Against Ferroptosis in Alzheimer's Disease: Integrating Network Pharmacology, Cell Membrane Chromatography, and Experimental Validation. [Abstract]

2025;53(4):1119-1154. PMID: 40582724
Am J Chin Med

Puerarin Attenuates Myocardial Ischemia-Reperfusion Damage by Targeting Ferroptosis through 14-3-3η Modulation. [Abstract]

2025;53(5):1501-1520. PMID: 40646505
Am J Chin Med

Sanguinarine Inhibits Gastric Cancer Progression by Targeting the NOS2/SOD1 Axis to Promote Ferroptosis. [Abstract]

2025;53(5):1545-1571. PMID: 40663435
Am J Chin Med

Astragaloside IV Improves Pulmonary Vascular Endothelial Dysfunction in Pulmonary Arterial Hypertension by Inhibiting Ferroptosis through Modulation of the Calpain-1/TGF-β/TFRC Pathway. [Abstract]

2025;53(4):1181-1206. PMID: 40582717
Am J Chin Med

Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway. [Abstract]

2025;53(4):1207-1224. PMID: 40582719
ACS Appl Mater Interfaces

Tannic Acid-Based Injectable Hydrogel Promotes the Recovery of Traumatic Brain Injury by Anti-Ferroptosis. [Abstract]

2025 Jun 4;17(22):31843-31858. PMID: 40402142
Stem Cell Res Ther

Reducing PDK4 level constitutes a pivotal mechanism for glucocorticoids to impede osteoblastic differentiation through the enhancement of ferroptosis in mesenchymal stem cells. [Abstract]

2025 Feb 25;16(1):91. PMID: 40001240
ACS Appl Mater Interfaces

Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment. [Abstract]

2025 Feb 26;17(8):11718-11730. PMID: 39963718
Stem Cell Res Ther

Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4. [Abstract]

2025 Feb 21;16(1):81. PMID: 39985001
Am J Chin Med

Panax notoginseng Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion. [Abstract]

2024;52(3):821-839. PMID: 38699996
Stem Cell Res Ther

Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. [Abstract]

2022 Sep 5;13(1):450. PMID: 36064453
Stem Cell Res Ther

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis. [Abstract]

2021 Jun 5;12(1):325. PMID: 34090492
Cell Rep

STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy. [Abstract]

2026 Jun 9;45(6):117515. PMID: 42268710
Cell Rep

circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis. [Abstract]

2025 Dec 5;44(12):116659. PMID: 41351835
Cell Rep

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]

2025 Sep 1;44(9):116139. PMID: 40892544
Cell Rep

Pp1-87B/PPP1CC-JNK axis integrates apoptosis and ferroptosis-like cell death to regulate cell competition and tumorigenesis. [Abstract]

2025 Sep 3;44(9):116240. PMID: 40906558
World J Gastroenterol

Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism. [Abstract]

2025 Aug 28;31(32):108654. PMID: 40900769
Cell Rep

Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer. [Abstract]

2025 Jul 23;44(8):116018. PMID: 40711881
Cell Rep

Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. [Abstract]

2024 Nov 28;43(12):114982. PMID: 39612244
World J Gastroenterol

Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis. [Abstract]

2023 Apr 21;29(15):2294-2309. PMID: 37124891
Cell Prolif

Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma. [Abstract]

2025 Jun;58(6):e13816. PMID: 40071723
Cell Prolif

CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway. [Abstract]

2021 Dec;54(12):e13142. PMID: 34632658
Cell Prolif

D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner. [Abstract]

2021 Nov;54(11):e13134. PMID: 34561933
Br J Pharmacol

Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway. [Abstract]

2025 Oct 8. PMID: 41063334
Br J Pharmacol

Silencing the fibronectin gene (FN1) improves NaCl-induced cardiac fibrosis via ferritinophagy-mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)-dependent manner. [Abstract]

2025 Sep 29. PMID: 41022663
Br J Pharmacol

A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death. [Abstract]

2025 May 13. PMID: 40356419
Chin J Nat Med

2024.
J Pineal Res

Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction. [Abstract]

2024 Sep;76(6):e12992. PMID: 39228264
Br J Pharmacol

Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel. [Abstract]

2024 Sep;181(17):3136-3159. PMID: 38715438
J Pineal Res

Sleep Deprivation Induces Gut Damage via Ferroptosis. [Abstract]

2024 Aug;76(5):e12987. PMID: 38975671
Br J Pharmacol

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis. [Abstract]

2021 Mar;178(5):1133-1148. PMID: 33347603
Chin Med

2026 Jul 8;21(1):185. PMID: 42421131
Chin Med

Ginsenoside Rb1 targets the NRF2-PPARγ-ACSL4 axis to inhibit PTECs ferroptosis. [Abstract]

2026 Jan 8;21(1):19. PMID: 41508002
Int J Radiat Oncol Biol Phys

Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma. [Abstract]

2023 Nov 15;117(4):966-978. PMID: 37244629
Int J Radiat Oncol Biol Phys

High dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38/NCOA4-mediated ferritinophagy/ferroptosis of endothelial cells. [Abstract]

2023 Sep 1;117(1):223-236. PMID: 37059236
Chin Med

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. [Abstract]

2022 Sep 29;17(1):115. PMID: 36175965
Neurotherapeutics

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. [Abstract]

2020 Oct;17(4):1796-1812. PMID: 32959272
J Med Chem

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma. [Abstract]

2026 Jun 11;69(11):13141-13164. PMID: 42216892
J Med Chem

Design, Synthesis, and Antitumor Evaluation of Novel Shikonin Derivatives: Discovery of 3k as a Dual Activator of the Integrated Stress Response and ROS in Gastric Cancer. [Abstract]

2026 Jun 11;69(11):13121-13140. PMID: 42205055
Food Sci Hum Wellness

2026 Jun 24.
J Med Chem

Phytohormone Strigolactams Overcomes Oxaliplatin Resistance in Colorectal Cancer by Blocking the Late-Stage Autophagy to Tip the Metabolic Balance toward Ferroptosis. [Abstract]

2025 Nov 27;68(22):24546-24559. PMID: 41208142
Food Sci Hum Wellness

2025.
J Med Chem

Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. [Abstract]

2024 Sep 12;67(17):15098-15117. PMID: 39145486
Metab Eng

Metabolic Engineering of CHO Cells Towards Cysteine Prototrophy and Systems Analysis of The Ensuing Phenotype. [Abstract]

2024 Jul:84:128-144. PMID: 38908817
J Med Chem

Developing a Gadolinium(III) Compound Based on Apoferritin for Targeted Magnetic Resonance Imaging and Dual-Modal Therapy of Cancer. [Abstract]

2023 Jun 8;66(11):7268-7279. PMID: 37218052
Food Science and Human Wellness

2023 Nov;12(6);2390-2407.
Int J Oncol

High‑throughput screening identification of a small‑molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis. [Abstract]

2023 Mar;62(3):42. PMID: 36825585
Int J Oncol

A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. [Abstract]

2022 Dec;61(6):148. PMID: 36222299
J Med Chem

Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy. [Abstract]

2019 Oct 10;62(19):8760-8772. PMID: 31509699
Environ Pollut

Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2-HO-1 signaling. [Abstract]

2026 Jun 1:398:128010. PMID: 41887355
Environ Pollut

Ferroptosis-mediated ocular developmental toxicity of biodegradable nanoplastics in zebrafish. [Abstract]

2026 Jan 1:388:127383. PMID: 41241370
Environ Pollut

"Iron -free" CdSe/ZnS quantum dots disrupt neural differentiation of embryonic stem cells via the induction of ferroptosis. [Abstract]

2025 Jul 1:376:126378. PMID: 40339883
Environ Pollut

Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway. [Abstract]

2025 Jul 1:376:126395. PMID: 40345373
Environ Pollut

Iron-doped diesel exhaust early-in-life inhalation-induced cardiopulmonary toxicity in chicken embryo: Roles of ferroptosis and acyl hydrocarbon signaling. [Abstract]

2024 Oct 5;363(Pt 1):125085. PMID: 39374763
Environ Pollut

Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis. [Abstract]

2024 Oct 15:359:124590. PMID: 39043312
Environ Pollut

Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway. [Abstract]

2024 May 15:349:123958. PMID: 38621452
Environ Pollut

Manganese-induced miR-125b-2-3p promotes anxiety-like behavior via TFR1-mediated ferroptosis. [Abstract]

2024 Mar 1:344:123255. PMID: 38159631
Environ Pollut

Methylmercury induced ferroptosis by interference of iron homeostasis and glutathione metabolism in CTX cells. [Abstract]

2023 Oct 15:335:122278. PMID: 37517642
Environ Pollut

Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice. [Abstract]

2023 May 15:325:121434. PMID: 36907243
Environ Pollut

Role of RNA m6A modification in titanium dioxide nanoparticle-induced acute pulmonary injury: An in vitro and in vivo study. [Abstract]

2022 Oct 15:311:119986. PMID: 36007795
Environ Pollut

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance. [Abstract]

2019 Nov;254(Pt A):112937. PMID: 31401526
Emerg Microbes Infect

Streptococcus suis Stk1 sensitizes epithelial cells to ferroptosis and exacerbates disruption of the respiratory epithelial barrier. [Abstract]

2026 Dec;15(1):2627066. PMID: 41630441
Front Immunol

NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis. [Abstract]

2026 Jan 13:16:1712786. PMID: 41607775
Fundam Res

2025 Dec 16.
EPMA J

Ferroptosis in acinar cells of traumatic pancreatitis: implications for predictive, preventive, and personalized approaches in intra-abdominal infection management. [Abstract]

2025 Sep 3;16(3):689-707. PMID: 40948981
Cancer Cell Int

Taurochenodeoxycholic acid suppresses the progression of glioblastoma via HMGCS1/HMGCR/GPX4 signaling pathway in vitro and in vivo. [Abstract]

2025 Apr 22;25(1):160. PMID: 40264142
Cancer Cell Int

Comprehensive network pharmacology and experimental study to investigate the effect and mechanism of solasonine on breast carcinoma treatment. [Abstract]

2025 Feb 17;25(1):49. PMID: 39962568
Cancer Cell Int

Digoxigenin activates autophagy in hepatocellular carcinoma cells by regulating the PI3K/AKT/mTOR pathway. [Abstract]

2024 Dec 18;24(1):405. PMID: 39696358
Cancer Cell Int

Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy. [Abstract]

2024 Jun 3;24(1):194. PMID: 38831301
J Invest Dermatol

The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma. [Abstract]

2023 Feb;143(2):305-316.e5. PMID: 36058299
J Invest Dermatol

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway. [Abstract]

2022 Jan;142(1):189-200.e8. PMID: 34242660
Appl Mater Today

2021, 101066.
Redox Rep

Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells. [Abstract]

2026 Dec;31(1):2632434. PMID: 41697789
Redox Rep

Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration. [Abstract]

2026 Dec;31(1):2618396. PMID: 41558682
Redox Rep

The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis. [Abstract]

2026 Dec;31(1):2643967. PMID: 41833934
Redox Rep

Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury. [Abstract]

2026 Dec 31;31(1):2657075. PMID: 41960638
Redox Rep

Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathways. [Abstract]

2026 Dec;31(1):2588866. PMID: 41526224
Redox Rep

Macrophage metabolic reprogramming via HIF-1α-glycolysis drives osteoblast ferroptosis and bone loss through an IL-6-STAT3-dependent redox axis. [Abstract]

2026 Dec 31;31(1):2667673. PMID: 42071169
Redox Rep

The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress. [Abstract]

2025 Dec;30(1):2588086. PMID: 41292488
Redox Rep

Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis. [Abstract]

2025 Dec;30(1):2503130. PMID: 40361284
Redox Rep

Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress. [Abstract]

2024 Dec;29(1):2428147. PMID: 39607819
Pharmaceutics

Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma. [Abstract]

2024 Sep 13;16(9):1205. PMID: 39339241
Lipids Health Dis

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis. [Abstract]

2023 Jul 8;22(1):99. PMID: 37422643
J Ethnopharmacol

Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. [Abstract]

2026 Oct 28:369:121932. PMID: 42219071
J Ethnopharmacol

Dandelion (Taraxacum mongolicum Hand. -Mazz.) extract inhibits triple-negative breast cancer by inducing ferroptosis via NCOA4-mediated ferritinophagy. [Abstract]

2026 May 23:363:121393. PMID: 41707813
Antioxid Redox Signal

Epitranscriptomic Control of Vascular Smooth Muscle Cell Ferroptosis by WTAP in the Pathogenesis of Vascular Restenosis. [Abstract]

2026 May;44(13-15):726-747. PMID: 41786513
J Ethnopharmacol

Ginsenoside Rg1 attenuates PM2.5-induced neurotoxicity by suppressing ferroptosis via the Nrf2/GPx4 axis. [Abstract]

2026 May 23:363:121464. PMID: 41775233
J Ethnopharmacol

Blockade of GPX4-mediated ferroptosis underlies the protective effect of Forsythiae Fructus water extract against poly(I:C)-induced inflammation. [Abstract]

2026 Mar 25:359:121076. PMID: 41423162
J Ethnopharmacol

Duhuo mitigates intervertebral disc degeneration by activating PI3K/AKT to inhibit ferroptosis in nucleus pulposus cells. [Abstract]

2026 Mar 1:358:121027. PMID: 41380858
J Ethnopharmacol

Sesamin promotes the survival of skin flaps in rats by inhibiting ferroptosis through the Nrf2/SLC7A11/GPX4 signaling pathway. [Abstract]

2026 Feb 28:357:120938. PMID: 41275941
JCI Insight

Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis. [Abstract]

2025 Nov 24;10(22):e187448. PMID: 41277553
Antioxid Redox Signal

Kindlin-2/Otub1/Slc7a11 Axis Improved Cardiac Ischemia Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis. [Abstract]

2025 Oct 13. PMID: 41081614
Antioxid Redox Signal

Empagliflozin Attenuates Diabetic Cardiomyopathy via Inhibiting Cardiomyocyte Ferroptosis Through the USP7/NRF2 Signaling Pathway. [Abstract]

2025 Sep 26. PMID: 41002023
J Ethnopharmacol

Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis. [Abstract]

2025 Aug 5;353(Pt A):120357. PMID: 40759297
J Ethnopharmacol

Erchen decoction alleviates silicosis by attenuating ferroptosis and fibrosis in alveolar macrophages via modulating the P53/HMOX1 pathway. [Abstract]

2025 Aug 29:352:120227. PMID: 40617365
J Ethnopharmacol

Buzhong yiqi decoction improves cisplatin resistance in non-small cell lung cancer by inhibiting PCBP1 to activate the ferritinophagy-mediated ferroptosis pathway. [Abstract]

2025 Jul 20;353(Pt A):120317. PMID: 40695404
Antioxid Redox Signal

ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity. [Abstract]

2025 Jun 2. PMID: 40455659
J Ethnopharmacol

Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis. [Abstract]

2025 May 28:348:119894. PMID: 40319933
J Ethnopharmacol

Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1α/HO-1/GPX4 axis. [Abstract]

2025 May 28:348:119912. PMID: 40316156
J Ethnopharmacol

Study on the effect of deer bone in improving rheumatoid arthritis based on the "drug-target-pathway" association network. [Abstract]

2025 Apr 25:346:119684. PMID: 40127831
J Ethnopharmacol

Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice. [Abstract]

2025 Apr 9:345:119571. PMID: 40023344
J Ethnopharmacol

Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway. [Abstract]

2025 Mar 13:343:119454. PMID: 39922329
J Ethnopharmacol

Modulating HIF-1α/HIF-2α homeostasis with Shen-Qi-Huo-Xue formula alleviates tubular ferroptosis and epithelial-mesenchymal transition in diabetic kidney disease. [Abstract]

2025 Mar 13:343:119478. PMID: 39947365
Antioxid Redox Signal

Lipotoxicity Induces Cardiomyocyte Ferroptosis via Activating the STING Pathway. [Abstract]

2025 Feb;42(4-6):184-198. PMID: 39001814
J Ethnopharmacol

XueBiJing injection improves the symptoms of sepsis-induced acute lung injury by mitigating oxidative stress and ferroptosis. [Abstract]

2025 Jan 30;337(Pt 1):118732. PMID: 39181287
J Ethnopharmacol

Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis. [Abstract]

2024 Nov 15:334:118582. PMID: 39009325
J Ethnopharmacol

Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. [Abstract]

2024 Aug 10:330:118214. PMID: 38641076
J Ethnopharmacol

Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway. [Abstract]

2024 Jun 28:328:118135. PMID: 38556139
J Ethnopharmacol

Danlou tablet attenuates ischemic stroke injury and blood‒brain barrier damage by inhibiting ferroptosis. [Abstract]

2024 Mar 25:322:117657. PMID: 38145861
J Ethnopharmacol

QiShenYiQi pills preserve endothelial barrier integrity to mitigate sepsis-induced acute lung injury by inhibiting ferroptosis. [Abstract]

2024 Mar 25:322:117610. PMID: 38122915
J Ethnopharmacol

Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation. [Abstract]

2023 Mar 25:304:116034. PMID: 36529245
Hum Reprod

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. [Abstract]

2021 Mar 18;36(4):951-964. PMID: 33378529
J Agric Food Chem

Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification. [Abstract]

2026 Apr 29;74(16):13162-13178. PMID: 41906758
J Agric Food Chem

Nonesterified Fatty Acids Cause Hepatic Ferroptosis in Dairy Cows via SIRT3-JNK Signaling. [Abstract]

2026 Mar 11;74(9):7553-7565. PMID: 41742716
Eur J Med Chem

Chemical induction of ferroptosis through GPX4 inhibition: Rational design of triazole-benzoxazine hybrids for melanoma therapy. [Abstract]

2026 Feb 5:303:118434. PMID: 41370972
J Agric Food Chem

Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway. [Abstract]

2025 Mar 22. PMID: 40119801
J Agric Food Chem

Astaxanthin Prevents Glucocorticoid-Induced Femoral Head Osteonecrosis by Targeting Ferroptosis through the JAK2/STAT3 Signaling Pathway. [Abstract]

2025 Feb 19;73(7):4270-4287. PMID: 39903514
J Agric Food Chem

Nuciferine Alleviates High-Fat Diet- and ApoE-/--Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway. [Abstract]

2024 Nov 6;72(44):24417-24431. PMID: 39445611
J Agric Food Chem

Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma. [Abstract]

2024 Nov 13;72(45):25173-25185. PMID: 39497239
J Agric Food Chem

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4. [Abstract]

2024 Mar 27;72(12):6178-6188. PMID: 38483540
J Agric Food Chem

Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux. [Abstract]

2023 Nov 1;71(43):16310-16322. PMID: 37871339
J Agric Food Chem

Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro. [Abstract]

2023 Oct 4;71(39):14365-14378. PMID: 37750412
J Agric Food Chem

Quercetin Alleviates Acrylamide-Induced Liver Injury by Inhibiting Autophagy-Dependent Ferroptosis. [Abstract]

2023 May 17;71(19):7427-7439. PMID: 37134181
J Agric Food Chem

A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. [Abstract]

2023 Feb 15;71(6):2745-2761. PMID: 36719855
Ecotoxicol Environ Saf

2026 Sep 1:322:120545. PMID: 42492176
Ecotoxicol Environ Saf

Nanoplastics and Benzo[a]pyrene Co-pollution aggravates pulmonary ferroptosis via endoplasmic reticulum stress-triggered IRE1α liquid-liquid phase separation. [Abstract]

2026 Jun 8:322:120347. PMID: 42259117
Ecotoxicol Environ Saf

Curcumin alleviates BPAF-induced ferroptosis in caprine endometrial epithelial cells through inhibition of endoplasmic reticulum stress and autophagy. [Abstract]

2026 May 14:318:120253. PMID: 42134007
Ecotoxicol Environ Saf

Chrysin reshapes ferroptosis sensitivity to reverse nickel refining fumes-induced lung injury via the miR-210/ANGPTL4 signaling axis mediated by the PHD1/HIF-1α pathway. [Abstract]

2026 May 13:318:120239. PMID: 42127541
CNS Neurosci Ther

Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the SIRT1/FOXO1/SLC7A11/GPX4 Pathway. [Abstract]

2026 Feb;32(2):e70798. PMID: 41718043
Ecotoxicol Environ Saf

Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]

2025 Sep 15:303:119045. PMID: 40945091
Ecotoxicol Environ Saf

Acute cadmium exposure damaged granulosa cell structure and blocked oocyte maturation via ferroptosis caused by intracellular iron overload and oxidative stress in mice. [Abstract]

2025 Sep 15:303:118851. PMID: 40803268
Ecotoxicol Environ Saf

Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc--GSH-GPX4 signaling pathway. [Abstract]

2025 Sep 1:302:118600. PMID: 40592152
Ecotoxicol Environ Saf

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis. [Abstract]

2025 Jan 15:290:117729. PMID: 39818137
Ecotoxicol Environ Saf

Fine particulate matter potentiates Th17-cell pathogenicity in experimental autoimmune uveitis via ferroptosis. [Abstract]

2024 Oct 1:284:116979. PMID: 39232294
Ecotoxicol Environ Saf

Diquat causes mouse testis injury through inducing heme oxygenase-1-mediated ferroptosis in spermatogonia. [Abstract]

2024 Jul 15:280:116562. PMID: 38850704
Ecotoxicol Environ Saf

Prolonged exposure to environmental levels of microcystin-LR triggers ferroptosis in brain via the activation of Erk/MAPK signaling pathway. [Abstract]

2023 Nov 15:267:115651. PMID: 37913581
Ecotoxicol Environ Saf

Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice. [Abstract]

2023 Jul 1:259:115049. PMID: 37235900
CNS Neurosci Ther

Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway. [Abstract]

2023 Jul;29(7):1923-1939. PMID: 36942513
CNS Neurosci Ther

Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes. [Abstract]

2022 Oct;28(10):1509-1518. PMID: 35698913
Ecotoxicol Environ Saf

Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction. [Abstract]

2022 Jun 15;238:113595. PMID: 35525119
Ecotoxicol Environ Saf

Perfluorooctanoic acid alters the developmental trajectory of female germ cells and embryos in rodents and its potential mechanism. [Abstract]

2022 May 1;236:113467. PMID: 35390687
Ecotoxicol Environ Saf

25 December 2021, 113028.
Ecotoxicol Environ Saf

LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. [Abstract]

2021 Sep 1:220:112376. PMID: 34051661
Biochem Pharmacol

2026 Oct:252:118224. PMID: 42409323
Biochem Pharmacol

Convergence of ER stress and ferroptosis in diabetic vasculopathy: therapeutic protection by ferrostatin-1. [Abstract]

2026 Aug;250(Pt 1):117998. PMID: 42025809
Biochem Pharmacol

Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis. [Abstract]

2026 Jul:249:117926. PMID: 41876017
Biochem Pharmacol

Celastrol induces liver cancer cell death via TFEB-mediated lysosome activation and ROS-dependent ferroptosis. [Abstract]

2026 Jun:248:117848. PMID: 41759594
Biochem Pharmacol

Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lipid peroxidation. [Abstract]

2026 Jun:248:117862. PMID: 41794265
Biochem Pharmacol

Sotorasib induces intestinal epithelial injury through suppression of the cAMP/PKA/CREB signaling axis. [Abstract]

2026 May 16:118078. PMID: 42144204
Cell Mol Life Sci

SLC25A21 promotes ferroptosis by inducing mitochondrial GPX4 deficiency in colorectal cancer. [Abstract]

2026 Apr 21. PMID: 42012504
Biochem Pharmacol

Almonertinib inhibits liver cancer progression by triggering autophagy-dependent ferroptosis through inhibition of the PI3K/Akt1/mTOR pathway. [Abstract]

2026 Mar:245:117628. PMID: 41380804
Biochem Pharmacol

Imperatorin induces ferroptosis via mediating lipid peroxidation and SLC7A11/ACSL4/GPX4 signaling for inhibition and therapeutics of prostate cancer. [Abstract]

2026 Mar:245:117683. PMID: 41506540
Biochem Pharmacol

PFKFB4-Mediated HSPB1 phosphorylation suppresses ferroptosis to Promote gastric cancer progression. [Abstract]

2026 Apr:246:117714. PMID: 41577048
Biochem Pharmacol

KDM2B promotes chemoresistance in glioma cells by inhibiting ferroptosis via the LINC01018/miR-182-5p axis. [Abstract]

2025 Dec;242(Pt 4):117416. PMID: 41077157
Cell Mol Life Sci

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [Abstract]

2025 Nov 14;82(1):406. PMID: 41236547
Biochem Pharmacol

Tetramethylpyrazine ameliorates sepsis-induced liver injury via inhibiting ferroptosis. [Abstract]

2025 Nov:241:117193. PMID: 40721008
Cell Mol Life Sci

Mechanism of LncRNA NORAD regulating ferroptosis in endometrial cancer cells by modifying GPX4 through FTO-mediated m6A methylation. [Abstract]

2025 Oct 25;82(1):364. PMID: 41137882
Biochem Pharmacol

Ghrelin attenuates metabolic dysfunction-associated steatotic liver disease by activating glutamine metabolism via inhibition of the IRE1α-XBP-1 pathway. [Abstract]

2025 Oct:240:117089. PMID: 40581331
Biochem Pharmacol

(-)-Epicatechin targets early growth response protein 1, an inflammation-associated ferroptosis regulator, to ameliorate metabolic dysfunction-associated steatotic liver disease. [Abstract]

2025 Oct:240:117100. PMID: 40619009
J Environ Sci

2025 Sep 30.
Biochem Pharmacol

PTBP1 acts as a tumor suppressor in glioma by promoting HMOX1-dependent ferroptosis. [Abstract]

2025 Sep:239:117041. PMID: 40484043
Biochem Pharmacol

SLC1A5 mediates myocardial damage after myocardial infarction by triggering cardiomyocyte ferroptosis. [Abstract]

2025 Sep:239:117047. PMID: 40490039
Biochem Pharmacol

Dimethylmalonate induces ferroptosis by inhibiting the SUCNR1/PI3K/HIF-1α/SLC7A11 signaling axis in triple-negative breast cancer. [Abstract]

2025 Sep:239:117051. PMID: 40532859
Biochem Pharmacol

Flubendazole inhibits cervical carcinoma by targeting DHODH to induce ferroptosis and mitophagy. [Abstract]

2025 Aug 28;242(Pt 1):117287. PMID: 40885318
Cell Mol Life Sci

Downregulation of FcRn promotes ferroptosis in herpes simplex virus-1-induced lung injury. [Abstract]

2025 Jan 6;82(1):36. PMID: 39760769
Cell Mol Life Sci

Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2. [Abstract]

2024 Jul 30;81(1):325. PMID: 39079969
Biochem Pharmacol

G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. [Abstract]

2024 Apr:222:116077. PMID: 38395264
Biochem Pharmacol

STING activation in macrophages by vanillic acid exhibits antineoplastic potential. [Abstract]

2023 Jul:213:115618. PMID: 37211172
Biochem Pharmacol

ALOX5 Promotes Autophagy-dependent Ferroptosis by Activating the AMPK/mTOR Pathway in Melanoma. [Abstract]

2023 Jun:212:115554. PMID: 37080437
Cancer Gene Ther

GOT1 promotes endometrial cancer progression by regulating ferroptosis through the STAT3-GPX4 axis and attenuating medroxyprogesterone acetate sensitivity. [Abstract]

2026 Jun 2. PMID: 42230821
Precis Clin Med

JS-K induces autophagy-dependent ferroptosis in bladder cancer: a multimodal mechanistic and translational study. [Abstract]

2026 Apr 25;9(2):pbag012. PMID: 42179765
Life Sci

Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis. [Abstract]

2026 Mar 1:388:124214. PMID: 41548594
Cell Insight

The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages. [Abstract]

2025 Jun 11;4(4):100257. PMID: 40677785
Life Sci

Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway. [Abstract]

2025 Mar 15:365:123452. PMID: 39923835
Ind Crops Prod

2024 Sep 1, 215, 118652.
Life Sci

FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells. [Abstract]

2020 Nov 1:260:118077. PMID: 32810509
Life Sci

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. [Abstract]

2020 Apr 15:247:117425. PMID: 32057904
Mol Metab

Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization. [Abstract]

2026 May 20:102382. PMID: 42155637
Prog Orthod

Ferroptosis inhibits cementoblast mineralization via cGAS-STING/GPX4 axis. [Abstract]

2026 Jan 13;27(1):1. PMID: 41528413
Prog Orthod

Inhibition of NCOA4/FTH1-mediated ferritinophagy attenuates ferroptosis in PDLCs and alleviates orthodontically induced inflammatory root resorption. [Abstract]

2025 Oct 28;26(1):43. PMID: 41148492
Food Front

2025 Aug 19.
Food Funct

Panaxynol from dietary sources modulates ferroptosis through ceRNA networks in synovium: a novel strategy for alleviating rheumatoid arthritis through functional food intervention. [Abstract]

2025 May 19;16(10):4104-4121. PMID: 40304116
Food Funct

Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway. [Abstract]

2024 May 7;15(9):4954-4969. PMID: 38602356
Mol Cell Proteomics

Proteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis. [Abstract]

2023 Dec;22(12):100672. PMID: 37866481
Mol Cell Proteomics

Sulconazole induces PANoptosis by triggering oxidative stress and inhibiting glycolysis to increase radiosensitivity in esophageal cancer. [Abstract]

2023 Jun;22(6):100551. PMID: 37076047
Food Funct

Juglone, a novel activator of ferroptosis, induces cell death in endometrial carcinoma Ishikawa cells. [Abstract]

2021 Jun 8;12(11):4947-4959. PMID: 34100505
Breast Cancer Res

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer. [Abstract]

2025 Jul 6;27(1):124. PMID: 40619388
Food Biosci

2024 Dec.
Inflamm Res

Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury. [Abstract]

2024 Oct;73(10):1727-1745. PMID: 39112649
Liver Int

Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1). [Abstract]

2024 Mar;44(3):691-705. PMID: 38082504
Liver Int

Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy. [Abstract]

2022 Dec;42(12):2889-2899. PMID: 36254713
Bioeng Transl Med

Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis. [Abstract]

2021 Dec 8;7(2):e10276. PMID: 35600640
Liver Int

Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. [Abstract]

2020 Jun;40(6):1378-1394. PMID: 32145145
Transl Res

GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis. [Abstract]

2024 Sep:271:79-92. PMID: 38797432
Drug Des Devel Ther

Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis. [Abstract]

2024 Feb 1:18:259-275. PMID: 38318502
Drug Des Devel Ther

Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells. [Abstract]

2022 Sep 7:16:2981-2993. PMID: 36105321
Drug Des Devel Ther

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells. [Abstract]

2019 Jul 2:13:2135-2144. PMID: 31456633
Biomater Sci

Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. [Abstract]

2019 Mar 26;7(4):1311-1322. PMID: 30734774
Pharm Biol

Majoon Ushba alleviated IL-17A sensitized keratinocyte ferroptosis via JAK-2-STAT-3 signaling axis and reversed imiquimod induced psoriasiform inflammation. [Abstract]

2026 Dec;64(1):575-598. PMID: 41973793
Pharm Biol

Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [Abstract]

2026 Dec;64(1):764-782. PMID: 42165632
Cells

Punicic Acid in Ovarian Cancer: Anticancer Activity and Mechanistic Insights. [Abstract]

2026 Jan;15(9):792. PMID: 42121893
Foods

Polysaccharides Extraction from Opuntia milpa alta and Their Protective Effect on Alcohol-Induced Neuro 2a Cell Damage via Ferroptosis. [Abstract]

2026 Jan 9;15(2):249. PMID: 41596848
Oncogenesis

ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer. [Abstract]

2025 Nov 21;14(1):45. PMID: 41271644
J Clin Transl Hepatol

GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis. [Abstract]

2024 Nov 28;12(11):917-929. PMID: 39544244
Cells

Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF. [Abstract]

2022 Nov 12;11(22):3580. PMID: 36429010
Cells

TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. [Abstract]

2022 Sep 26;11(19):2992. PMID: 36230956
Cells

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis. [Abstract]

2022 Aug 17;11(16):2560. PMID: 36010637
Int J Pharm

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells. [Abstract]

2019 Dec 15:572:118782. PMID: 31678528
Colloids Surf B Biointerfaces

Arginine tagged liposomal carrier for the delivery of celastrol for ferroptosis-induced hepatocellular carcinoma therapy. [Abstract]

2025 Jun:250:114546. PMID: 39919344
ACS Appl Nano Mater

2026 Jan 9;9(3):1696-1709.
Nat Prod Bioprospect

Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour. [Abstract]

2026 Jan 9;16(1):10. PMID: 41507578
Commun Biol

Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC. [Abstract]

2025 Dec 10;8(1):1772. PMID: 41372608
Commun Biol

Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets. [Abstract]

2025 Nov 20;8(1):1626. PMID: 41266595
Commun Biol

Biphasic protective effects of macrophage migration inhibitory factor in ischemia/reperfusion-induced acute kidney injury. [Abstract]

2025 Jul 28;8(1):1112. PMID: 40721484
Commun Biol

Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration. [Abstract]

2025 Jul 29;8(1):1118. PMID: 40731132
Commun Biol

Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury. [Abstract]

2025 Feb 3;8(1):159. PMID: 39901028
Commun Biol

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1. [Abstract]

2024 Oct 8;7(1):1279. PMID: 39379617
Commun Biol

Human α-synuclein aggregation activates ferroptosis leading to parvalbumin interneuron degeneration and motor learning impairment. [Abstract]

2024 Oct 1;7(1):1227. PMID: 39349708
Commun Biol

PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis. [Abstract]

2024 Apr 9;7(1):429. PMID: 38594496
Cancer Nanotechnol

2023 Nov 13.
Nutrients

Biomimetic Nanozymes Suppressed Ferroptosis to Ameliorate Doxorubicin-Induced Cardiotoxicity via Synergetic Effect of Antioxidant Stress and GPX4 Restoration. [Abstract]

2023 Feb 22;15(5):1090. PMID: 36904089
Front Bioeng Biotechnol

Tocopherol attenuates the oxidative stress of BMSCs by inhibiting ferroptosis through the PI3k/AKT/mTOR pathway. [Abstract]

2022 Aug 17:10:938520. PMID: 36061427
Nutrients

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes. [Abstract]

2020 Sep 27;12(10):2954. PMID: 32992479
Cancer Biol Ther

2026 Dec 31;27(1):2695501. PMID: 42377119
Cancer Biol Ther

Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis. [Abstract]

2026 Dec 31;27(1):2676474. PMID: 42189063
Eur J Pharmacol

Inhibition of ferroptosis exerts renal protective effects in membranous nephropathy rats via the Nrf2/HO-1 pathway. [Abstract]

2026 May 28:1025:178898. PMID: 42044765
Eur J Pharmacol

Pharmacological inhibition of fatty acid-binding protein 4 alleviates sepsis-associated acute kidney injury in mice via suppressing ferroptosis. [Abstract]

2026 May 30:1030:179061. PMID: 42219054
Eur J Pharmacol

Artesunate reverses gefitinib resistance in lung adenocarcinoma by inducing ferroptosis and suppressing the Wnt/β-catenin pathway. [Abstract]

2026 Apr 28:1022:178856. PMID: 41967624
Eur J Pharmacol

Carnosic acid protects against mitochondrial dysfunction and ferroptosis in myocardial ischemia/reperfusion injury through mediating Mfn2. [Abstract]

2026 Mar 28:1019:178690. PMID: 41765272
Mar Drugs

Fucoxanthin Induces Ferroptosis in Hypopharyngeal Carcinoma Cells by Activating the p53/SLC7A11/GPX4 Axis. [Abstract]

2026 Jan 27;24(2):55. PMID: 41745458
Cell Biol Toxicol

FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation. [Abstract]

2026 Mar 4;42(1):50. PMID: 41781602
Mitochondrion

Sensitivity of primary mitochondrial disease fibroblasts to ferroptosis: The role of intracellular iron. [Abstract]

2026 Mar:87:102112. PMID: 41581630
Eur J Pharmacol

Leonurine attenuates cisplatin-induced AKI-CKD transition via Nrf2-Mediated ferroptosis suppression. [Abstract]

2026 Jan 30:1013:178508. PMID: 41448263
Clin Epigenetics

WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia. [Abstract]

2025 Nov 19;17(1):195. PMID: 41257944
Eur J Pharmacol

Targeting eEF2K induces oxidative stress and sensitizes cancer cells to ferroptosis induction. [Abstract]

2025 Aug 15:1001:177746. PMID: 40409701
Pharmaceuticals (Basel)

Drug Pair of Astragali Radix-Ligustri Lucidi Fructus Alleviates Acute Kidney Injury in Mice Induced by Ischemia-Reperfusion Through Inhibiting Ferroptosis. [Abstract]

2025 May 25;18(6):789. PMID: 40573186
Mar Drugs

Marine Sponge-Derived Gukulenin A Sensitizes Ovarian Cancer Cells to PARP Inhibition via Ferroptosis Induction. [Abstract]

2025 Mar 22;23(4):138. PMID: 40278259
Mar Drugs

Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]

2025 Mar 12;23(3):123. PMID: 40137309
Cell Biol Toxicol

Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer. [Abstract]

2025 Feb 26;41(1):52. PMID: 40000487
Cell Biol Toxicol

Targeting p38γ synergistically enhances sorafenib-induced cytotoxicity in hepatocellular carcinoma. [Abstract]

2025 Jan 28;41(1):35. PMID: 39871031
Eur J Pharmacol

Longikaurin A induces ferroptosis and inhibits glioblastoma progression through DNA methylation - Mediated GPX4 suppression. [Abstract]

2024 Dec 5:984:177061. PMID: 39426467
Eur J Pharmacol

Exendin-4 promotes ischemia-reperfusion flap survival by upregulating Gpx4 to inhibit ferroptosis. [Abstract]

2024 Dec 5:984:177029. PMID: 39366501
Cell Biol Toxicol

NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer. [Abstract]

2024 Oct 30;40(1):93. PMID: 39476297
Mar Drugs

Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells. [Abstract]

2024 Aug 6;22(8):357. PMID: 39195474
Pharmaceuticals (Basel)

Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway. [Abstract]

2024 Jul 2;17(7):871. PMID: 39065721
Eur J Pharmacol

Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1. [Abstract]

2024 Jul 5:974:176620. PMID: 38685305
Eur J Pharmacol

Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway. [Abstract]

2024 May 15:971:176524. PMID: 38561102
Reprod Biol Endocrinol

Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression. [Abstract]

2024 Apr 11;22(1):41. PMID: 38605340
Eur J Pharmacol

Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats. [Abstract]

2024 Feb 5:964:176298. PMID: 38145645
Eur J Pharmacol

Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway. [Abstract]

2024 Jan 15:963:176264. PMID: 38123006
Eur J Pharmacol

Identification and experimental validation of Stearoyl-CoA desaturase is a new drug therapeutic target for osteosarcoma. [Abstract]

2024 Jan 15:963:176249. PMID: 38070637
Respir Res

CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD. [Abstract]

2023 Dec 1;24(1):301. PMID: 38041059
Eur J Pharmacol

Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. [Abstract]

2023 Oct 15:957:176009. PMID: 37619784
Eur J Pharmacol

Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis. [Abstract]

2023 Oct 5:956:175967. PMID: 37549729
Eur J Pharmacol

Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis. [Abstract]

2023 Apr 5:944:175516. PMID: 36758783
Eur J Pharmacol

Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. [Abstract]

2023 Mar 15:943:175569. PMID: 36740037
Eur J Pharmacol

Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage. [Abstract]

2022 Sep 15:931:175175. PMID: 35921957
Eur J Pharmacol

Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress. [Abstract]

2022 Aug 5:928:175119. PMID: 35753403
Front Endocrinol

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice. [Abstract]

2021 Feb 18:12:626390. PMID: 33679620
Respir Res

Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. [Abstract]

2020 Sep 9;21(1):232. PMID: 32907551
Int Immunopharmacol

2026 Oct 1:186:117098. PMID: 42385643
Int Immunopharmacol

2026 Oct 1:186:117093. PMID: 42419145
Int J Mol Sci

2026 Jul 18;27(14):6391. PMID: 42511738
Int J Mol Sci

2026 Jul 14;27(14):6265. PMID: 42511609
Int Immunopharmacol

2026 Jul 28:187:117174. PMID: 42520681
Int Immunopharmacol

2026 Jul 24:187:117176. PMID: 42497660
Int Immunopharmacol

Kaempferide alleviates glucocorticoid-induced osteoporosis by targeting ferroptosis through the GSK3β/Nrf-2/GPX4 pathway. [Abstract]

2026 Jun 15:179:116601. PMID: 41962468
Int Immunopharmacol

Synergistic induction of ferroptosis by paclitaxel and sunitinib is mediated through SLC7A11 in lung cancer. [Abstract]

2026 Jun 15:179:116595. PMID: 41955701
Int Immunopharmacol

MCL inhibits macrophage ferroptosis through the NRF2/HO-1/GPX4 axis to attenuate carotid atherosclerotic plaque formation. [Abstract]

2026 Jun 22:185:117056. PMID: 42330582
Int J Mol Sci

Bufalin Suppresses Pancreatic Ductal Adenocarcinoma Through ER Stress-Ferroptosis Crosstalk Associated with IP3R-Linked Ca2+ Dysregulation and ATF3/SLC7A11 Regulation. [Abstract]

2026 May 14;27(10):4373. PMID: 42196362
Int J Mol Sci

Uric Acid Induces Hepatocytes Ferroptosis Through HIF-2α/DMT1-Mediated Iron Overload. [Abstract]

2026 Mar 20;27(6):2833. PMID: 41898692
Cell Oncol (Dordr)

NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4. [Abstract]

2026 Mar 18;49(2):57. PMID: 41848996
Int J Mol Sci

MED12 Dictates Epithelial Ovarian Cancer Cell Ferroptosis Sensitivity via YAP-TEAD1 Signaling. [Abstract]

2026 Jan 20;27(2):1020. PMID: 41596664
Int Immunopharmacol

Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2. [Abstract]

2026 Jan 15:169:115974. PMID: 41370977
Biomolecules

RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells. [Abstract]

2025 Dec 18;15(12):1749. PMID: 41463402
Int Immunopharmacol

Cucurbitacin B suppresses malignant progression of oral leukoplakia via ferroptosis-induced macrophage polarization. [Abstract]

2025 Sep 13:165:115485. PMID: 40946669
Int J Mol Sci

NEDD4L-Mediated Ubiquitination of GPX4 Exacerbates Doxorubicin-Induced Cardiotoxicity. [Abstract]

2025 Aug 23;26(17):8201. PMID: 40943126
Int Immunopharmacol

OTUD1 inhibits macrophage ferroptosis via regulation of AMPK and GSK3β/β-catenin signaling pathways exerting protective effects in sepsis-induced acute lung injury. [Abstract]

2025 Jul 28:160:114985. PMID: 40460602
Int J Mol Sci

Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway. [Abstract]

2025 Jul 25;26(15):7204. PMID: 40806353
Int Immunopharmacol

Silencing of activating transcription factor 3 alleviates oxidative stress and inflammation and improves cognitive dysfunction in vascular dementia rats by repressing ferroptosis. [Abstract]

2025 Jun 17:158:114730. PMID: 40347885
Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 Jun 17:158:114827. PMID: 40359890
Int Immunopharmacol

Exploring the role of Mitoferrin-1 in Ferroptosis and mitochondrial damage in acute ischemic stroke. [Abstract]

2025 May 16:155:114625. PMID: 40199135
Int J Mol Sci

Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway. [Abstract]

2025 May 24;26(11):5075. PMID: 40507886
Int Immunopharmacol

Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis. [Abstract]

2025 Apr 16:152:114400. PMID: 40058106
Int Immunopharmacol

Mesenchymal stromal cells reduce ferroptosis of podocytes by activating the Nrf2/HO-1/GPX4 pathway in lupus nephritis. [Abstract]

2025 Apr 24:153:114537. PMID: 40147265
Int J Mol Sci

Smilax glabra Flavonoids Inhibit AMPK Activation and Induce Ferroptosis in Obesity-Associated Colorectal Cancer. [Abstract]

2025 Mar 10;26(6):2476. PMID: 40141120
Int Immunopharmacol

Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma. [Abstract]

2025 Mar 26:150:114278. PMID: 39954659
Int Immunopharmacol

Microglial HO-1 aggravates neuronal ferroptosis via regulating iron metabolism and inflammation in the early stage after intracerebral hemorrhage. [Abstract]

2025 Feb 6:147:113942. PMID: 39740507
Int Immunopharmacol

Hesperetin alleviates PM2.5-induced lung injury by inhibiting ferroptosis in an Nrf2-dependent manner. [Abstract]

2025 Feb 20:148:114123. PMID: 39884081
Biomolecules

Angiotensin II Induces Vascular Endothelial Dysfunction by Promoting Lipid Peroxidation-Mediated Ferroptosis via CD36. [Abstract]

2024 Nov 17;14(11):1456. PMID: 39595632
Int Immunopharmacol

Interleukin-17D accelerates atherosclerosis through promoting endothelial cells ferroptosis via CD93/miR-181a-5p/SLC7A11 signaling. [Abstract]

2024 Nov 6;143(Pt 3):113558. PMID: 39510035
Int Immunopharmacol

Apigenin alleviates Sjögren's syndrome-induced salivary gland epithelial cell ferroptosis via ERα signaling-mediated regulation of the ATF3/SLC7A1l axis. [Abstract]

2024 Oct 17;143(Pt 2):113409. PMID: 39426238
Int Immunopharmacol

PKCδ modulates SP1 mediated mitochondrial autophagy to exacerbate diacetylmorphine-induced ferroptosis in neurons. [Abstract]

2024 Oct 25;143(Pt 2):113468. PMID: 39490143
Int Immunopharmacol

Liraglutide alleviates ferroptosis in renal ischemia reperfusion injury via inhibiting macrophage extracellular trap formation. [Abstract]

2024 Sep 27;142(Pt B):113258. PMID: 39340991
Int Immunopharmacol

Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE. [Abstract]

2024 Sep 10:138:112617. PMID: 38972213
Int Immunopharmacol

Inhibitors of APE1 redox and ATM synergistically sensitize osteosarcoma cells to ionizing radiation by inducing ferroptosis. [Abstract]

2024 Sep 30:139:112672. PMID: 39032469
Int Immunopharmacol

Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway. [Abstract]

2024 Sep 6;142(Pt A):113065. PMID: 39243557
Int J Mol Sci

Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway. [Abstract]

2024 Sep 29;25(19):10509. PMID: 39408842
Int J Mol Sci

Isopropyl 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoate Alleviates Palmitic Acid-Induced Vascular Aging in HUVEC Cells through ROS/Ferroptosis Pathway. [Abstract]

2024 Aug 27;25(17):9278. PMID: 39273228
Int Immunopharmacol

Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis. [Abstract]

2024 Jun 15:134:112159. PMID: 38692018
Int Immunopharmacol

Asiaticoside promoted ferroptosis and suppressed immune escape in gastric cancer cells by downregulating the Wnt/β-catenin pathway. [Abstract]

2024 Jun 15:134:112175. PMID: 38733821
Int J Mol Sci

Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis. [Abstract]

2024 Feb 20;25(5):2458. PMID: 38473706
Int J Mol Sci

Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats. [Abstract]

2024 Jan 7;25(2):763. PMID: 38255838
Int Immunopharmacol

TMEM16A deficiency in alveolar type 2 epithelial cells protected against endoplasmic reticulum stress-induced ferroptosis during acute lung injury. [Abstract]

2023 Nov 15;125(Pt B):111208. PMID: 37976603
Int Immunopharmacol

BzATP reverses ferroptosis-induced gut microbiota disorders in collagen-induced arthritis mice. [Abstract]

2023 Sep 13;124(Pt A):110885. PMID: 37713784
Int Immunopharmacol

Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4+ T cells after liver transplantation in rat. [Abstract]

2023 Aug 23;124(Pt A):110810. PMID: 37625370
Int Immunopharmacol

Identification and verification of hub genes associated with ferroptosis in ischemia and reperfusion injury during renal transplantation. [Abstract]

2023 Jul:120:110393. PMID: 37279643
Int Immunopharmacol

Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease. [Abstract]

2023 Jul:120:110290. PMID: 37216800
Int Immunopharmacol

FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. [Abstract]

2023 Mar:116:109762. PMID: 36702076
Int Immunopharmacol

Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPK-mediated autophagy. [Abstract]

2023 Feb:115:109658. PMID: 36608444
Int Immunopharmacol

Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss. [Abstract]

2023 Jan:114:109607. PMID: 36700777
Int J Mol Sci

Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii. [Abstract]

2022 Dec 23;24(1):229. PMID: 36613672
Int Immunopharmacol

Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis. [Abstract]

2022 Dec;113(Pt A):109359. PMID: 36288647
Int Immunopharmacol

Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. [Abstract]

2022 Nov:112:109162. PMID: 36067654
Int J Mol Sci

Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice. [Abstract]

2022 Nov 10;23(22):13828. PMID: 36430312
Int J Mol Sci

The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway. [Abstract]

2022 Sep 20;23(19):11004. PMID: 36232313
Int Immunopharmacol

Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury. [Abstract]

2022 Jun:107:108687. PMID: 35279512
Int J Mol Sci

Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. [Abstract]

2022 Apr 26;23(9):4783. PMID: 35563172
Artif Cells Nanomed Biotechnol

The efficacy and potential mechanism of cnidium lactone to inhibit osteoclast differentiation. [Abstract]

2019 Dec;47(1):3087-3093. PMID: 31343277
Biol Direct

NSDHL as a regulator of lipid peroxidation and ER stress-mediated apoptosis in ovarian cancer. [Abstract]

2026 Apr 8;21(1):68. PMID: 41952197
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
Mol Neurobiol

Puerarin Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through SLC7A11/GPX4/ACSL4 Axis and Alleviate Pyroptosis Through Caspase-1/GSDMD Axis. [Abstract]

2025 Jul;62(7):8931-8948. PMID: 40056342
Mol Neurobiol

OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress. [Abstract]

2025 Jun;62(6):7557-7575. PMID: 39915357
Invest Ophthalmol Vis Sci

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice. [Abstract]

2025 Jun 2;66(6):28. PMID: 40488714
Biol Direct

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma. [Abstract]

2025 Feb 7;20(1):19. PMID: 39920793
Neurochem Int

Ferritinophagy promotes microglia ferroptosis to aggravate neuroinflammation induced by cerebral ischemia-reperfusion injury via activation of the cGAS-STING signaling pathway. [Abstract]

2025 Feb:183:105920. PMID: 39732341
Biol Direct

Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis. [Abstract]

2024 Jul 23;19(1):57. PMID: 39039611
Front Cell Infect Microbiol

Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis. [Abstract]

2022 Feb 4;12:825824. PMID: 35186798
Inflammation

FBXW7-Mediated Downregulation of GPX4 Aggravates Acute Kidney Injury Following Ischemia‒Reperfusion. [Abstract]

2025 Jun;48(3):1484-1498. PMID: 39207602
Front Pharmacol

Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer. [Abstract]

2025 Jun 4:16:1567942. PMID: 40535769
Inflammation

Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury. [Abstract]

2025 May 13. PMID: 40358793
Am J Respir Cell Mol Biol

FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in COPD. [Abstract]

2025 May;72(5):551-562. PMID: 39453438
mBio

The long noncoding RNA APR attenuates PPRV infection-induced accumulation of intracellular iron to inhibit membrane lipid peroxidation and viral replication. [Abstract]

2025 Apr 9;16(4):e0012725. PMID: 40126010
Inflammation

MLKL-Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage. [Abstract]

2025 Apr 7. PMID: 40195182
Front Pharmacol

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway. [Abstract]

2025 Mar 26:16:1527316. PMID: 40206070
Inflammation

Targeting Lcn2 to Inhibit Myocardial Cell Ferroptosis is a Potential Therapy for Alleviating Septic Cardiomyopathy. [Abstract]

2025 Feb 3. PMID: 39899131
Inflammation

4-octyl Itaconate Attenuates Acute Pancreatitis and Associated Lung Injury by Suppressing Ferroptosis in Mice. [Abstract]

2025 Feb 7. PMID: 39920558
Front Pharmacol

β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. [Abstract]

2024 Oct 17:15:1469180. PMID: 39484165
COLLOID SURFACE A

2023 Apr 13, 131458.
Front Pharmacol

Resveratrol Attenuate Myocardial Injury by Inhibiting Ferroptosis Via Inducing KAT5/GPX4 in Myocardial Infarction. [Abstract]

2022 May 24:13:906073. PMID: 35685642
Front Pharmacol

Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. [Abstract]

2021 May 10:12:670224. PMID: 34040532
Front Pharmacol

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells. [Abstract]

2019 Sep 3:10:968. PMID: 31551778
Animal Research and One Health

2025 Nov 12.
J Ovarian Res

M6A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis. [Abstract]

2025 Nov 29;19(1):4. PMID: 41316396
J Ovarian Res

Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction. [Abstract]

2024 May 18;17(1):107. PMID: 38762721
Front Cell Dev Biol

Exosomal MIF Derived From Nasopharyngeal Carcinoma Promotes Metastasis by Repressing Ferroptosis of Macrophages. [Abstract]

2021 Dec 31:9:791187. PMID: 35036405
Front Cell Dev Biol

Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation. [Abstract]

2021 Dec 16:9:751593. PMID: 34977009
Chem Biol Interact

F-53B exacerbates doxorubicin-induced cardiotoxicity by impairing NRF2-dependent ferroptosis defense. [Abstract]

2026 Aug 1:436:112210. PMID: 42297177
Chem Biol Interact

Polystyrene nanoplastics induce hippocampal damage and cognitive deficits through oxidative stress-triggered microglial extracellular traps and neuronal ferroptosis. [Abstract]

2026 Jul 1:434:112120. PMID: 42070744
Chem Biol Interact

Co-exposure to PS-NPs and HFPO-TA potentiates reproductive toxicity via ferroptosis and SLC1A5-Mediated glutamine deprivation in male mice. [Abstract]

2026 Jun 1:432:112059. PMID: 41887313
Chem Biol Interact

Cyclophosphamide-induced iron homeostasis imbalance triggers ovarian toxicity through ferroptosis of ovarian granulosa cells in a mitophagy crosstalk manner. [Abstract]

2026 Jun 1:432:112047. PMID: 41861985
Chem Biol Interact

Exposure to polyethylene microplastics induces a male testosterone synthesis disorder via oxidative stress-mediated ferroptosis. [Abstract]

2026 May 25:435:112171. PMID: 42191080
Chem Biol Interact

A novel HDAC1-Hcy/Glu-ferroptosis axis underlies valproic acid-induced hepatic steatosis. [Abstract]

2026 Apr 28:112112. PMID: 42061694
J Nutr Biochem

Ferroptosis inhibition by spermidine via the NCOA4/Ferritin axis and polyamine-microbiota dysbiosis in ulcerative colitis. [Abstract]

2026 Apr:150:110222. PMID: 41352542
ACS Omega

RS-1: A Novel Hydrophobic Tagging GPX4 Degrader Inducing Ferroptosis and Suppressing Tumor Growth. [Abstract]

2026 Feb 2;11(6):9098-9106. PMID: 41726627
Chem Biol Interact

Oridonin exposure induces testicular impairment through regulating ferroptosis via HIF-1α/HO-1 activation and STUB1-driven GPX4 ubiquitination-dependent degradation. [Abstract]

2026 Jan 5:423:111838. PMID: 41265811
Chem Biol Interact

Novel insights into male reproductive toxicity: autophagy-dependent ferroptosis triggered by polylactic acid nanoplastics and copper sulfate. [Abstract]

2025 Nov 1:421:111740. PMID: 40947090
Biofactors

Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90/GPX4 Ubiquitination. [Abstract]

2025 Nov-Dec;51(6):e70063. PMID: 41292183
J Nutr Biochem

P-coumaric-acid ameliorates acute kidney injury induced by ischemia-reperfusion injury via suppressing ferroptosis. [Abstract]

2025 Nov 7:149:110175. PMID: 41207539
J Nutr Biochem

1,25(OH)2D3 ameliorates DSS-induced intestinal ferroptosis through the SIRT3-SOD2-mtROS pathway. [Abstract]

2025 Oct:144:109999. PMID: 40513839
Chem Biol Interact

Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7/GPX4 regulatory axis in chronic obstructive pulmonary disease. [Abstract]

2025 Oct 22:420:111697. PMID: 40769290
Chem Biol Interact

A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC. [Abstract]

2025 Oct 22:420:111693. PMID: 40754060
Chem Biol Interact

Erianin reverses 5-FU resistance by targeting CALM1/CAMKK2 and activating autophagy in colorectal cancer. [Abstract]

2025 Sep 19:111750. PMID: 40976489
Microchem J

2025 Sep 9;218:115245.
ACS Omega

Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson's Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation. [Abstract]

2025 Sep 16;10(38):44447-44460. PMID: 41048757
Chem Biol Interact

Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. [Abstract]

2025 Sep 4:111724. PMID: 40914538
Chem Biol Interact

FB1 causes barrier damage to vascular endothelial cells through ferroptosis by a PINK1/Parkin mediated mitophagy-dependent mechanism. [Abstract]

2025 Aug 1:416:111536. PMID: 40324642
J Integr Med

Morin inhibits ubiquitination degradation of BCL-2 associated agonist of cell death and synergizes with BCL-2 inhibitor in gastric cancer cells. [Abstract]

2025 Apr 22:S2095-4964(25)00050-0. PMID: 40319008
Toxicology

Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance. [Abstract]

2025 Mar:512:154078. PMID: 39921026
Toxicology

Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease. [Abstract]

2025 Feb:511:154067. PMID: 39864238
Microchem J

2024 Dec.
Toxicology

Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis. [Abstract]

2024 Nov 10:509:153996. PMID: 39532264
Toxicology

CYP2E1 mediated deoxynivalenol-induced hepatocyte toxicity by regulating ferroptosis. [Abstract]

2024 Nov:508:153923. PMID: 39147090
Chem Biol Interact

Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4. [Abstract]

2024 Apr 25:393:110944. PMID: 38518851
J Nutr Biochem

Dietary docosahexaenoic acid plays an opposed role in ferroptotic and non-ferroptotic acute kidney injury. [Abstract]

2023 Oct:120:109418. PMID: 37490984
Chem Biol Interact

Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. [Abstract]

2023 Sep 1:382:110602. PMID: 37302459
Chem Biol Interact

Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis. [Abstract]

2023 Sep 25:383:110684. PMID: 37648051
Toxicology

Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance. [Abstract]

2023 May 15:490:153514. PMID: 37075931
Chem Biol Interact

Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway. [Abstract]

2022 Aug 1:362:110004. PMID: 35661779
Toxicology

Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation. [Abstract]

2022 Jan 15:465:153055. PMID: 34864093
Bioorg Chem

DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer. [Abstract]

2026 Aug 5:177:109901. PMID: 42048687
Bioorg Chem

Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis. [Abstract]

2026 Jul 5:175:109753. PMID: 41875752
Bioorg Chem

A mitochondria-targeting glutathione fluorescent probe reveals distinct mitochondria-endoplasmic reticulum contact between disulfidptosis and ferroptosis. [Abstract]

2026 Feb:169:109437. PMID: 41453306
Spine J

Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc. [Abstract]

2025 Mar;25(3):597-608. PMID: 39522771
Molecules

Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents. [Abstract]

2025 Feb 24;30(5):1031. PMID: 40076255
Molecules

Study on the Antitumor Mechanism of Tanshinone IIA In Vivo and In Vitro through the Regulation of PERK-ATF4-HSPA5 Pathway-Mediated Ferroptosis. [Abstract]

2024 Mar 30;29(7):1557. PMID: 38611836
Molecules

Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H2S via Inhibition of Ferroptosis. [Abstract]

2023 Jun 14;28(12):4770. PMID: 37375325
Molecules

Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. [Abstract]

2022 Sep 24;27(19):6311. PMID: 36234847
World J Diabetes

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction. [Abstract]

2021 Feb 15;12(2):124-137. PMID: 33594332
Mol Med Rep

ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression. [Abstract]

2026 Jul;34(1):202. PMID: 42169636
J Mol Med (Berl)

The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis. [Abstract]

2026 Apr 23;104(1):68. PMID: 42020785
Food Sci Nutr

Curcumin Protected CoCl2-Induced Apoptosis and Ferroptosis in Human Umbilical Vein Endothelial Cells by Regulating the Expression of HSPA6. [Abstract]

2026 Jan 5;14(1):e71343. PMID: 41502827
Mol Med Rep

PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis. [Abstract]

2026 Jan;33(1):4. PMID: 41104863
Mol Med Rep

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway. [Abstract]

2026 Jan;33(1):24. PMID: 41201015
J Mol Med (Berl)

Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis. [Abstract]

2025 Dec 20;104(1):10. PMID: 41419644
Food Sci Nutr

Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway. [Abstract]

2025 Sep 17;13(9):e70952. PMID: 40969904
Biochim Biophys Acta Mol Basis Dis

Polyphyllin I inhibits glioblastoma progression by initiating ferroptosis via the Sirt1/Nrf2/HO-1/GPX4 signaling cascade. [Abstract]

2025 Aug 26;1872(1):168028. PMID: 40876787
Biochim Biophys Acta Mol Basis Dis

Oncogenic HNF4α inhibits ferroptotic cell death through activating SLC7A11 by recruiting p300/CBP in breast cancer. [Abstract]

2025 Aug;1871(6):167884. PMID: 40320185
Mol Med Rep

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis. [Abstract]

2025 Jul;32(1):202. PMID: 40376993
Biochim Biophys Acta Mol Basis Dis

PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease. [Abstract]

2025 Mar;1871(3):167645. PMID: 39743023
Eur J Pharm Biopharm

Cancer cell membrane-camouflaged curcumin nanoparticles trigger ferroptosis for accurate gastric cancer therapy. [Abstract]

2024 Nov:204:114509. PMID: 39362384
Biochim Biophys Acta Mol Basis Dis

Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome. [Abstract]

2024 Jun;1870(5):167182. PMID: 38653359
Biochim Biophys Acta Mol Basis Dis

Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis. [Abstract]

2024 Jun;1870(5):167215. PMID: 38714267
Mol Med Rep

Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. [Abstract]

2024 May;29(5):75. PMID: 38488028
Mol Med Rep

Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress. [Abstract]

2024 May;29(5):84. PMID: 38516760
Biochim Biophys Acta Mol Basis Dis

MTH1 inhibition synergizes with ROS-inducing agents to trigger cervical cancer cells undergoing parthanatos. [Abstract]

2024 Apr 22;1870(5):167190. PMID: 38657912
Mol Med Rep

Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death. [Abstract]

2023 Nov;28(5):202. PMID: 37711057
Mol Med Rep

Activating autophagy and ferroptosis of 3‑Chloropropane‑1,2‑diol induces injury of human umbilical vein endothelial cells via AMPK/mTOR/ULK1. [Abstract]

2023 Mar;27(3):76. PMID: 36799162
Biochim Biophys Acta Mol Basis Dis

BTB domain and CNC homolog 1 promotes glioma invasion mainly through regulating extracellular matrix and increases ferroptosis sensitivity. [Abstract]

2022 Dec 1;1868(12):166554. PMID: 36181980
Mol Med Rep

Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. [Abstract]

2022 Aug;26(2):256. PMID: 35703358
Sci Rep

2026 Jul 8. PMID: 42420410
Sci Rep

VKORC1L1-mediated vitamin K recycling counters ferroptosis to promote endothelial repair. [Abstract]

2026 Jun 19;16(1):19171. PMID: 42321255
PLoS Pathog

MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway. [Abstract]

2026 Apr 24;22(4):e1014170. PMID: 42030333
Mater Today Commun

2026 Apr 30;53:115309.
Sci Rep

Cancer-associated fibroblasts -derived Tenascin-C activates the Hippo/TAZ pathway to suppress ferroptosis and confer cisplatin resistance in esophageal cancer. [Abstract]

2026 Apr 27. PMID: 42045517
Sci Rep

APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer. [Abstract]

2026 Mar 15;16(1):13595. PMID: 41840064
Sci Rep

Ferroptosis inhibits biological behaviors of glioma cells by downregulating Galectin-9 transcriptional level via extracellular Acetyl-HMGB1. [Abstract]

2026 Mar 29;16(1):10681. PMID: 41905987
Sci Rep

Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy. [Abstract]

2026 Mar 6;16(1):12384. PMID: 41792305
Sci Rep

HACE1 alleviates intervertebral disc degeneration by inhibiting ferroptosis in nucleus pulposus cells. [Abstract]

2026 Feb 13;16(1):8996. PMID: 41688644
Cell Calcium

Basic calcium phosphate crystals aggravate senescence-related osteoarthritis through GPX4-NRF2-mediated ferroptosis. [Abstract]

2026 Mar:134:103123. PMID: 41581266
J Mol Cell Cardiol

DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy. [Abstract]

2026 Jan 19:213:14-30. PMID: 41565199
Transl Oncol

The CHPT-pSTAT3-SLC7A11 signaling axis controls progression and ferroptosis susceptibility of pancreatic cancer. [Abstract]

2026 Jan:63:102624. PMID: 41337814
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
J Mol Cell Cardiol

ZIP14 upregulation leads to ferroptosis and lysosomal dysfunction through intracellular iron overload and induces myocardial ischemia/reperfusion injury in mouse hearts. [Abstract]

2025 Nov 27:211:78-91. PMID: 41317841
Am J Pathol

Growth Differentiation Factor 11 Attenuates Photoaging through Ferroptosis Pathway in SZ95 Sebocytes. [Abstract]

2025 Sep 12:S0002-9440(25)00332-3. PMID: 40946799
Cancer Sci

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1. [Abstract]

2025 Aug;116(8):2256-2269. PMID: 40485050
Sci Rep

Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis. [Abstract]

2025 Aug 18;15(1):30197. PMID: 40825957
Sci Rep

Leveraging diverse cell death patterns in osteosarcoma patients and identification of the function of FADS2 in osteosarcoma cells. [Abstract]

2025 Jul 1;15(1):20831. PMID: 40593006
Sci Rep

Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition. [Abstract]

2025 Jul 9;15(1):24789. PMID: 40634437
Cancer Sci

TP-0903 Suppresses Aurora A-PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome-Derived Cell Line. [Abstract]

2025 Jul 28. PMID: 40722126
Mediators Inflamm

HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis. [Abstract]

2025 Jul 11:2025:2395557. PMID: 40689397
Sci Rep

The ferroptotic effect of NRF2-GCLM signaling axis derived by radiotherapy of esophageal squamous cell cancer: the vivo study. [Abstract]

2025 Jul 24;15(1):26917. PMID: 40707557
Sci Rep

TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway. [Abstract]

2025 May 12;15(1):16448. PMID: 40355596
Sci Rep

Edaravone dexborneol provides neuroprotective benefits by suppressing ferroptosis in experimental intracerebral hemorrhage. [Abstract]

2025 May 13;15(1):16595. PMID: 40360664
PLoS Pathog

Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases. [Abstract]

2025 Apr 8;21(4):e1013060. PMID: 40198689
Transl Oncol

Anlotinib induced ferroptosis through the p53/xCT/GPX4 pathway in non-small cell lung cancer. [Abstract]

2025 Mar:53:102289. PMID: 39827731
Sci Rep

Dapagliflozin inhibits ferroptosis and ameliorates renal fibrosis in diabetic C57BL/6J mice. [Abstract]

2025 Feb 28;15(1):7117. PMID: 40016517
Transl Oncol

LPCAT3 regulates the proliferation and metastasis of serous ovarian cancer by modulating arachidonic acid. [Abstract]

2025 Feb:52:102256. PMID: 39733744
Sci Rep

Exploring Liraglutide's mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway. [Abstract]

2025 Jan 12;15(1):1754. PMID: 39799153
Sci Rep

RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel. [Abstract]

2025 Jan 11;15(1):1654. PMID: 39794456
Sci Rep

Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis. [Abstract]

2025 Jan 7;15(1):1141. PMID: 39774712
Sci Rep

EGCG activates Keap1/P62/Nrf2 pathway, inhibits iron deposition and apoptosis in rats with cerebral hemorrhage. [Abstract]

2024 Dec 28;14(1):31474. PMID: 39732956
PLoS Pathog

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia. [Abstract]

2024 Nov 5;20(11):e1012614. PMID: 39499730
Toxics

Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells. [Abstract]

2024 Aug 31;12(9):644. PMID: 39330572
Am J Pathol

Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion. [Abstract]

2024 Jul;194(7):1197-1217. PMID: 38537935
Sci Rep

Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η. [Abstract]

2024 Jul 2;14(1):15246. PMID: 38956068
J Lipid Res

Hyperactivation of SREBP induces Pannexin-1-dependent lytic cell death. [Abstract]

2024 Jul;65(7):100579. PMID: 38880128
Sci Rep

Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson's disease. [Abstract]

2024 Jul 2;14(1):15107. PMID: 38956066
Transl Oncol

A novel SLC3A2-targeting antibody-drug conjugate exerts potent antitumor efficacy in head and neck squamous cell cancer. [Abstract]

2024 Jul:45:101981. PMID: 38703658
Sci Rep

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin. [Abstract]

2024 Jun 21;14(1):14307. PMID: 38906931
Mol Pharm

Saponin and Ribosome-Inactivating Protein Synergistically Trigger Lysosome-Dependent Apoptosis by Inhibiting Lysophagy: Potential to Become a New Antitumor Strategy. [Abstract]

2024 Jun 3;21(6):2993-3005. PMID: 38722865
Transl Oncol

Exploring the role of disulfidptosis-related signatures in immune microenvironment, prognosis and therapeutic strategies of cervical cancer. [Abstract]

2024 Jun:44:101938. PMID: 38492499
Sci Rep

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [Abstract]

2024 May 30;14(1):12427. PMID: 38816543
Sci Rep

Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma. [Abstract]

2024 Apr 25;14(1):9509. PMID: 38664521
Sci Rep

The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk. [Abstract]

2024 Mar 18;14(1):6504. PMID: 38499622
Sci Rep

Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis. [Abstract]

2024 Feb 9;14(1):3335. PMID: 38336964
Mol Pharm

Fe(II)-Targeted PET/19F MRI Dual-Modal Molecular Imaging Probe for Early Evaluation of Anticancer Drug-Induced Acute Kidney Injury. [Abstract]

2023 Oct 2;20(10):5185-5194. PMID: 37711135
Mediators Inflamm

lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4. [Abstract]

2023 Aug 16:2023:5513245. PMID: 37621767
Mediators Inflamm

Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease. [Abstract]

2023 Jul 19:2023:6623329. PMID: 37501933
Sci Rep

Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer. [Abstract]

2022 Nov 12;12(1):19396. PMID: 36371529
Sci Rep

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. [Abstract]

2019 Nov 7;9(1):16185. PMID: 31700067
Exp Neurol

Combined targeting of iron overload and BLVRA synergistically attenuates reactive astrocytes after subarachnoid hemorrhage. [Abstract]

2026 Aug:402:115791. PMID: 42031091
Cancers (Basel)

NSUN4 Suppresses Ferroptosis Through m5C-Dependent Stabilization of C-MYC and Activation of the PI3K/Akt Signaling Pathway in Cervical Cancer. [Abstract]

2026 Apr 28;18(9):1392. PMID: 42122190
Cancers (Basel)

Targeting ATR and PI3Kα Pathways Promotes Ferroptosis in PIK3CA-Wildtype Platinum-Resistant Endometrial Cancer. [Abstract]

2026 Mar 25;18(7):1064. PMID: 41976288
Cancers (Basel)

Triptolide Triggers Protective Autophagy via ROS Induction in NSCLC: Therapeutic Synergy with Autophagy Inhibition. [Abstract]

2026 Mar 11;18(6):902. PMID: 41899507
Cancers (Basel)

Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism. [Abstract]

2025 Dec 27;18(1):92. PMID: 41514605
Eur J Med Res

Mechanism of methyltransferase METTL14 mediating m6A modification and regulating SIRT5 expression to promote ferroptosis and repress gastric cancer progression. [Abstract]

2025 Nov 12;30(1):1115. PMID: 41225679
Eur J Med Res

TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells. [Abstract]

2025 Aug 5;30(1):713. PMID: 40764595
Eur J Med Res

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer. [Abstract]

2025 Aug 4;30(1):704. PMID: 40760677
Exp Neurol

Inhibition of mitoNEET ameliorates traumatic brain injury-induced ferroptosis and cognitive dysfunction by stabilizing dihydroorotate dehydrogenase. [Abstract]

2025 Jul:389:115235. PMID: 40189124
Eur J Med Res

Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway. [Abstract]

2025 Jun 6;30(1):463. PMID: 40481609
Eur J Med Res

RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis. [Abstract]

2025 Jan 4;30(1):3. PMID: 39754243
Eur J Med Res

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2. [Abstract]

2024 Dec 20;29(1):611. PMID: 39702296
Stem Cells

Amphiregulin secreted by umbilical cord Multipotent Stromal Cells protects against ferroptosis of macrophages via the Activating Transcription Factor 3-CD36 axis to alleviate endometrial fibrosis. [Abstract]

2024 Aug 1;42(8):763-776. PMID: 38733123
Exp Neurol

Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4. [Abstract]

2024 Mar:373:114659. PMID: 38141803
Exp Neurol

Anacardic acid improves neurological deficits in traumatic brain injury by anti-ferroptosis and anti-inflammation. [Abstract]

2023 Dec:370:114568. PMID: 37820939
Cancers (Basel)

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway. [Abstract]

2023 Apr 23;15(9):2427. PMID: 37173894
Cancers (Basel)

Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. [Abstract]

2022 Jan 11;14(2):345. PMID: 35053507
Neoplasia

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Dec;23(12):1227-1239. PMID: 34768109
Neuropharmacology

Hypericin alleviates high glucose-induced ferroptosis in cultured rat satellite glial cells via targeting P2X7R to activate the Akt/GSK3β/Nrf2 axis. [Abstract]

2026 Nov 1:298:111050. PMID: 42214457
Neuropharmacology

Sevoflurane-induced neurotoxicity in neonatal mice is driven by microglial ferroptosis via MSTRG.7388-dependent NCOA4/STING axis. [Abstract]

2026 Aug 15:294:110978. PMID: 42009246
Oncol Rep

Schisandrin B exhibits anti‑proliferative effects by inducing ferroptosis in pancreatic cancer. [Abstract]

2026 Aug;56(2):147. PMID: 42318966
Cell Signal

TP53 links mitochondria-endoplasmic reticulum crosstalk and ferroptosis in septic cardiomyopathy: Protective modulation by nicorandil. [Abstract]

2026 Aug:144:112537. PMID: 41997516
Oncol Rep

2026 Aug;56(2):151. PMID: 42438262
Cell Signal

2026 Jul 4:112722. PMID: 42401358
Mol Cell Biochem

S-equol promotes ferroptosis in triple negative breast cancer by coordinating NCOA4-mediated ferritinophagy and PPARγ-mediated lipid metabolism. [Abstract]

2026 May;481(5):2119-2137. PMID: 41925800
J Mater Sci Mater Med

Engineered membrane-coated nanoparticles enhance ferroptosis and microtubule inhibition in prostate cancer. [Abstract]

2026 May 21. PMID: 42165953
J Cell Mol Med

Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway. [Abstract]

2026 Feb;30(3):e70911. PMID: 41614426
J Cell Mol Med

Kaempferol Mitigates CSE-Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2/NCOA4/GPx4 Axis. [Abstract]

2026 Jan;30(1):e71010. PMID: 41474210
Cell Signal

Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment. [Abstract]

2025 Dec:136:112116. PMID: 40930476
Med Oncol

Scutellarin triggers ferroptosis in ovarian cancer cells via inhibiting AKT/mTOR and JAK2/STAT3 pathways. [Abstract]

2025 Nov 25;43(1):24. PMID: 41288840
Cell Signal

CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway. [Abstract]

2025 Nov:135:111998. PMID: 40664345
Cell Signal

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62. [Abstract]

2025 Nov:135:112024. PMID: 40721064
Cell Signal

IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3. [Abstract]

2025 Oct:134:111906. PMID: 40436288
Mol Cell Biochem

CIITA was involved in regulating ACSL4-dependent ferroptosis in gastric cancer cells. [Abstract]

2025 Oct 20. PMID: 41114762
Cell Signal

PRAP1 regulates colorectal cancer cell proliferation and ferroptosis through the Nrf2 signaling pathway. [Abstract]

2025 Oct:134:111863. PMID: 40373840
Cell Signal

Natural exosome-like nanovesicles from Salvia chinensis Benth induce ferroptosis to suppress hepatocellular carcinoma progression via AMPK/Nrf2/xCT axis. [Abstract]

2025 Oct:134:111928. PMID: 40484104
Cell Signal

Oxidized-LDL aggravates renal injury via tubular cuproptosis. [Abstract]

2025 Aug:132:111839. PMID: 40306349
Oncol Rep

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. [Abstract]

2025 Aug;54(2):94. PMID: 40539448
Cell Signal

Mitochondrial ferritin inhibition aggravates pacing-induced ventricular arrhythmias after myocardial infarction by promoting cardiomyocyte ferroptosis. [Abstract]

2025 Jul:131:111683. PMID: 40023300
Mol Cell Biochem

STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis. [Abstract]

2025 Jul;480(7):4265-4281. PMID: 40087208
J Cell Mol Med

Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis. [Abstract]

2025 Jul;29(13):e70691. PMID: 40586853
J Cell Mol Med

Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer. [Abstract]

2025 Jul;29(14):e70710. PMID: 40682485
J Cell Mol Med

Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. [Abstract]

2025 Jul;29(13):e70592. PMID: 40576283
Cell Signal

Exploring the molecular mechanisms through which overexpression of TET3 alleviates liver fibrosis in mice via ferroptosis in hepatic stellate cells. [Abstract]

2025 Jul:131:111747. PMID: 40096933
J Cell Mol Med

Inhibitors of p53 Apoptosis-Stimulating Protein Mitigate Acute Kidney Injury by Modulating the HIF-1α/SLC7A11 Pathway to Suppress Ferroptosis. [Abstract]

2025 Jun;29(11):e70580. PMID: 40492946
J Cell Mol Med

Downregulation of Alox5 Inhibits Ferroptosis to Improve Doxorubicin-Induced Cardiotoxicity via the P53/SLC7A11 Pathway. [Abstract]

2025 Jun;29(11):e70641. PMID: 40485049
Mol Cell Biochem

A new gold(I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species. [Abstract]

2025 Apr;480(4):2265-2276. PMID: 38782835
Cell Signal

HMGB1 secretion by resveratrol in NSCLC: A pathway to ferroptosis-mediated platelet activation suppression. [Abstract]

2025 Mar:127:111607. PMID: 39842527
J Cell Mol Med

ADAM17/PTGS2 Facilitates Pulmonary Fibrosis by Regulating Ferroptosis. [Abstract]

2025 Mar;29(5):e70466. PMID: 40077919
Neuropharmacology

Gallic acid and loganic acid attenuate amyloid-β oligomer-induced microglia damage via NF-КB signaling pathway. [Abstract]

2025 Feb 1:263:110215. PMID: 39536861
J Cell Mol Med

Loss of FTH1 Induces Ferritinophagy-Mediated Ferroptosis in Anaemia of Myelodysplastic Syndromes. [Abstract]

2025 Jan;29(1):e70350. PMID: 39804099
J Cell Mol Med

Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1. [Abstract]

2024 Dec;28(24):e70313. PMID: 39730981
J Cell Mol Med

Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins. [Abstract]

2024 Nov;28(22):e70188. PMID: 39543084
J Cell Mol Med

NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma. [Abstract]

2024 Sep;28(18):e70062. PMID: 39317954
Cell Signal

Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis. [Abstract]

2024 Sep:121:111278. PMID: 38944257
Cell Signal

Thiostrepton induces oxidative stress, mitochondrial dysfunction and ferroptosis in HaCaT cells. [Abstract]

2024 Sep:121:111285. PMID: 38969192
J Cell Mol Med

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation. [Abstract]

2024 Apr;28(7):e18212. PMID: 38516826
J Cell Mol Med

Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway. [Abstract]

2024 Apr;28(8):e18335. PMID: 38652216
Virol Sin

Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia. [Abstract]

2024 Feb;39(1):31-43. PMID: 37690733
Cell Signal

PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway. [Abstract]

2024 Jan:113:110974. PMID: 37972803
J Cell Mol Med

KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m6 A-dependent posttranscriptional modification of SLC7A11. [Abstract]

2023 Dec;27(24):4118-4132. PMID: 37830241
Med Oncol

Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma. [Abstract]

2023 Apr 10;40(5):141. PMID: 37036615
Cell Signal

Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. [Abstract]

2021 Dec:88:110167. PMID: 34628002
J Cell Mol Med

Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. [Abstract]

2021 Apr;25(7):3300-3311. PMID: 33611811
Aquat Toxicol

2026 Jul 16:299:107936. PMID: 42497826
J Inflamm Res

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [Abstract]

2026 Jun 19:19:596461. PMID: 42345001
J Inflamm Res

2026 Jan 21;19:1-16.
J Inflamm Res

CYBB-Mediated Ferroptosis Drives Podocyte Injury in Lupus Nephritis and Represents a Therapeutic Target. [Abstract]

2026 Jan 22:19:575320. PMID: 41867462
J Neurochem

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [Abstract]

2025 Oct;169(10):e70246. PMID: 41017138
J Inflamm Res

Parishin Protects Against Sepsis-Induced Intestinal Injury by Modulating the ACSL4/p-Smad3/PGC-1α Pathway: An Integrated Approach of Bioinformatics and Experimental Validation. [Abstract]

2025 Oct 15:18:14283-14305. PMID: 41126972
Aquat Toxicol

2-Hydroxyanthraquinone induces cardiotoxicity in zebrafish via ferroptosis. [Abstract]

2025 Sep:286:107485. PMID: 40669437
J Inflamm Res

Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense. [Abstract]

2025 Jul 29:18:10061-10079. PMID: 40761383
J Inflamm Res

Integrated Analysis and Validation of Ferroptosis-Related Genes Associated with Ischemia/Reperfusion Injury in Lung Transplantation. [Abstract]

2025 Jan 7:18:251-270. PMID: 39802518
J Inflamm Res

Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury. [Abstract]

2024 Dec 13:17:11041-11053. PMID: 39691306
J Inflamm Res

Cardamonin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis Through Promoting STAT3 Signaling. [Abstract]

2024 Nov 15:17:8861-8879. PMID: 39569022
J Inflamm Res

Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson's Disease Through the LCN2/NLRP3 Signaling Pathway. [Abstract]

2024 Aug 23:17:5599-5618. PMID: 39193124
J Inflamm Res

Mesenchymal Stem Cells Ameliorate DSS-Induced Experimental Colitis by Modulating the Gut Microbiota and MUC-1 Pathway. [Abstract]

2023 May 11:16:2023-2039. PMID: 37197438
Hum Gene Ther

HIV Tat- conjugated Histone H3 peptides induce tumor cell death via cellular stress responses. [Abstract]

2023 Jan;34(1-2):42-55. PMID: 36373826
Ann N Y Acad Sci

2026 Jul;1561(1):e70339. PMID: 42478898
iScience

ALDH3A2-mediated fatty acid synthesis induces ferroptosis and AML drug resistance. [Abstract]

2026 Jun 2;29(6):116202. PMID: 42291184
Poult Sci

2026 Jun 19.
Poult Sci

Ferroptosis bridges early-life oxidative stress and lifetime meat quality defects in broilers. [Abstract]

2026 May 15;105(8):107133. PMID: 42184739
iScience

Hint2 deficiency aggravates mitochondria-associated ferroptosis in lung ischemia-reperfusion injury. [Abstract]

2026 May 22;29(6):116068. PMID: 42231980
Acta Biochim Biophys Sin (Shanghai)

Curcumin suppresses head and neck squamous cell carcinoma progression via NCOA4-FTH1-mediated ferroptosis. [Abstract]

2026 May 27. PMID: 42271129
iScience

Ceritinib induces ferroptosis via TRIM21-mediated GLUT1 ubiquitination and AMPK-driven metabolic reprogramming in breast cancer. [Abstract]

2026 Apr 22;29(6):115846. PMID: 42181273
iScience

Atmospheric particulate matter impairs pulmonary barriers by triggering FTH1-mediated ferroptosis. [Abstract]

2026 Feb 28;29(4):115177. PMID: 41858633
Neurochem Res

HAT1 Protects Against Cerebral Ischemia Injury by Inhibiting TFRC-Mediated Ferroptosis. [Abstract]

2025 Dec 29;51(1):24. PMID: 41460540
Poult Sci

Aflatoxin B1 triggers ferroptosis via inhibiting the NRF2 signaling pathway in duck granulosa cells. [Abstract]

2025 Dec;104(12):105993. PMID: 41197355
iScience

2025 Dec 5.
ACS Chem Neurosci

Knockdown SIRT6 Alleviates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage through Inhibiting Ferroptosis by Promoting SMARCA2 Acetylation. [Abstract]

2025 Aug 6;16(15):2989-3002. PMID: 40698625
iScience

Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway. [Abstract]

2025 Jul 24;28(8):113196. PMID: 40822356
Acta Biochim Biophys Sin (Shanghai)

Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating Nrf2 signaling. [Abstract]

2025 Aug 19. PMID: 40831377
iScience

NRF2 regulates lipid droplet dynamics to prevent lipotoxicity. [Abstract]

2025 Jun 18;28(7):112925. PMID: 40678507
Neurochem Res

Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury. [Abstract]

2025 Jun 21;50(4):204. PMID: 40542883
Poult Sci

Duck House Inhalable Particulate Matter Induces Lung Injury by Activating Ferroptosis. [Abstract]

2025 Apr 16;104(8):105169. PMID: 40403547
Acta Biochim Biophys Sin (Shanghai)

Characterization of the mechanisms underlying sulfasalazine-induced ferroptotic cell death: role of protein disulfide isomerase-mediated NOS activation and NO accumulation. [Abstract]

2025 Aug 21. PMID: 40836799
Biosci Rep

Identification and Functional Validation of ACSL1 as a Biomarker Regulating Ferroptosis in Nucleus Pulposus Cell. [Abstract]

2025 Apr 2;45(4):215-231. PMID: 40042449
Biologics

STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression. [Abstract]

2024 Jul 4:18:181-193. PMID: 38979130
iScience

USP7 upregulated by TGF-β1 promotes ferroptosis via inhibiting LATS1-YAP axis in sepsis-induced acute lung injury. [Abstract]

2024 Apr 5;27(6):109667. PMID: 38966570
Mol Nutr Food Res

Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin. [Abstract]

2024 Apr;68(7):e2300343. PMID: 38501770
iScience

A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury. [Abstract]

2024 Mar 15;27(4):109511. PMID: 38571759
Brain Res Bull

Nrf-2 modulates excitability of hippocampal neurons by regulating ferroptosis and neuroinflammation after subarachnoid hemorrhage in rats. [Abstract]

2024 Feb:207:110877. PMID: 38215951
iScience

Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression. [Abstract]

2023 Jul 17;26(8):107408. PMID: 37554459
Acta Biochim Biophys Sin (Shanghai)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells. [Abstract]

2023 Mar 20;55(8):1288-1300. PMID: 36942991
Brain Res Bull

TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β signaling pathway. [Abstract]

2023 Feb:193:146-157. PMID: 36596364
Acta Biochim Biophys Sin (Shanghai)

Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol. [Abstract]

2022 Jan 25;54(1):64-76. PMID: 35130622
Acta Biochim Biophys Sin (Shanghai)

Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer. [Abstract]

2021 Mar 2;53(3):333-341. PMID: 33522578
Mol Oncol

Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest. [Abstract]

2021 Feb;15(2):725-738. PMID: 33226737
Brain Res Bull

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects. [Abstract]

2019 Nov:153:122-132. PMID: 31442590
Endocr Relat Cancer

2026 Jun 8;33(6):e260018. PMID: 42160309
Aquaculture

2026 Jun 1;625:744253.
Comp Biochem Physiol C Toxicol Pharmacol

Prothioconazole induced stereoselective developmental toxicity and liver injury in zebrafish embryos via ferroptosis. [Abstract]

2026 Feb:300:110380. PMID: 41177498
BMC Complement Med Ther

Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells. [Abstract]

2024 Apr 25;24(1):174. PMID: 38664638
BMC Complement Med Ther

Ammidin ameliorates myocardial hypoxia/reoxygenation injury by inhibiting the ACSL4/AMPK/mTOR-mediated ferroptosis pathway. [Abstract]

2023 Dec 15;23(1):459. PMID: 38102654
Aquaculture

2024 Jan 30, 579, 740203.
J Pharmacol Exp Ther

2026 Jun 17;393(8):104968. PMID: 42442018
FASEB J

Transcriptional Control by FOXO4 Regulates Trophoblast Differentiation and Safeguards Placental Development Through MITD1- and PCBP2-Mediated Redox Homeostasis. [Abstract]

2026 Jun 15;40(11):e71971. PMID: 42201761
FASEB J

3,4-Dimethoxychalcone Protects Against Steroid Induced Femoral Head Necrosis by Suppressing Ferroptosis via Activation of STAT3-Nrf2 Signaling Pathway. [Abstract]

2026 Jun 30;40(12):e72021. PMID: 42268673
FASEB J

CAF-Secreted Exosomes Deliver BMP4 to Confer Radiotherapy Resistance in Cervical Cancer Through a Novel Mechanism Linking Nrf2 Activation to Cuproptosis Inhibition. [Abstract]

2026 May 15;40(9):e71838. PMID: 42081167
FASEB J

Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]

2026 Mar 31;40(6):e71636. PMID: 41842655
FASEB J

Cordycepin Suppressed Ferroptosis to Ameliorate Acute Kidney Injury Through Inhibiting the DNMT1/KLF15/FTH1 Axis. [Abstract]

2026 Jan 31;40(2):e71488. PMID: 41575219
FASEB J

EM2, a Novel Elephantopus mollis H.B.K. Monomer, Enhances Radiosensitivity in Cervical Cancer Through Dual Inhibition of AKT and Autophagy. [Abstract]

2026 Jan 31;40(2):e71454. PMID: 41527777
FASEB J

SUCLA2 Inhibited Lysine Succinylation of SHMT2 to Suppress Ferroptosis and Renal Interstitial Fibrosis. [Abstract]

2025 Dec 15;39(23):e71314. PMID: 41359112
FASEB J

The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis. [Abstract]

2025 Dec 15;39(23):e71289. PMID: 41351524
Water Biol Secur

2025 Nov 13.
FASEB J

LEF1 Suppresses Ferroptosis in Colorectal Cancer Cells by Targeted Promotion of SLC7A11 Transcription. [Abstract]

2025 Nov 30;39(22):e71231. PMID: 41258989
Lung

The Down-Regulation of Lactoferrin Expression Induced by Cigarette Smoke can Induce Ferroptosis in COPD. [Abstract]

2025 Sep 23;203(1):96. PMID: 40986113
Biol Trace Elem Res

Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring. [Abstract]

2025 Sep;203(9):4543-4560. PMID: 39912999
FASEB J

ACSL3/GABARAPL2 Ameliorates Vascular Endothelial Cell Aging and Injury Through Protective Autophagy to Alleviate Ferroptosis. [Abstract]

2025 Aug 31;39(16):e70912. PMID: 40802494
FASEB J

Modulating ATOH1 and POU4F3 Pathways to Enhance Hair Cell Regeneration and Inhibit Ferroptosis in Cochlear Support Cells. [Abstract]

2025 Jul 31;39(14):e70866. PMID: 40719825
FASEB J

Artesunate induces ferroptosis in osteosarcoma through NCOA4-mediated ferritinophagy. [Abstract]

2025 Apr 15;39(7):e70488. PMID: 40168090
FASEB J

Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality. [Abstract]

2025 Mar 31;39(6):e70469. PMID: 40100097
FASEB J

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway. [Abstract]

2025 Jan 15;39(1):e70298. PMID: 39760183
FASEB J

Glutathione S-transferase-Pi 1 protects cells from irradiation-induced death by inhibiting ferroptosis in pancreatic cancer. [Abstract]

2024 Sep;38(17):e70033. PMID: 39258853
Biol Trace Elem Res

Arsenic-Induced Ferroptosis in Chicken Hepatocytes via the Mitochondrial ROS Pathway. [Abstract]

2024 Sep;202(9):4180-4190. PMID: 38102534
FASEB J

SREBP-1-mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury. [Abstract]

2024 Jul 15;38(13):e23806. PMID: 38970404
FASEB J

Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway. [Abstract]

2023 Jun;37(6):e22992. PMID: 37219513
Antiviral Res

Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. [Abstract]

2023 Mar:211:105542. PMID: 36646387
Nanomedicine

Delivery of Mir-196c-3p with NIR-II light-triggered gel attenuates cardiomyocyte ferroptosis in cardiac ischemia-reperfusion injury. [Abstract]

2023 Jan:47:102618. PMID: 36270453
FASEB J

Entacapone alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2022 Jul;36(7):e22399. PMID: 35691001
FASEB J

HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma. [Abstract]

2022 Jun;36(6):e22359. PMID: 35621121
FASEB J

Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss. [Abstract]

2022 Mar;36(3):e22147. PMID: 35104016
Drug Dev Res

2026 Aug;87(5):e70340. PMID: 42418246
Fish Shellfish Immunol

The AhR/ROS-mediated lipid peroxidation pathway contributes to 6PPDQ-induced intestine-specific injury in zebrafish during embryonic development. [Abstract]

2026 Jun:173:111268. PMID: 41819393
FEBS J

Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro. [Abstract]

2025 Dec 3. PMID: 41340229
Fish Shellfish Immunol

Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus). [Abstract]

2025 Oct 8:168:110908. PMID: 41067592
Drug Dev Res

Xanthatin inhibits non-small cell lung cancer proliferation by breaking the redox balance. [Abstract]

2022 Aug;83(5):1176-1189. PMID: 35466412
FEBS J

Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration. [Abstract]

2022 Apr;289(7):1968-1983. PMID: 34741776
Am J Physiol Endocrinol Metab

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. [Abstract]

2021 May 1;320(5):E925-E937. PMID: 33813878
Curr Issues Mol Biol

IL-1β/EPAS1-Associated Ferroptotic Stress Impairs Skeletal Stem/Progenitor Cell Function in Inflammation-Associated Fracture Nonunion. [Abstract]

2026 Jun 9;48(6):606. PMID: 42353610
J Biol Chem

The iron-sulfur cluster assembly factor FDX2 is required for tumor initiation but not for growth of established tumors in transplantation models. [Abstract]

2026 May 27;302(7):113200. PMID: 42208897
J Biol Chem

Low-dose EGFR inhibition unlocks ferroptosis susceptibility to sensitize chemotherapy in EGFR-high triple-negative breast cancer. [Abstract]

2026 May 25:113185. PMID: 42190815
Curr Issues Mol Biol

Protective Effect of Apocynum venetum L. Leaves Extract Against Diabetic Cardiomyopathy: Inhibition of Oxidative Stress and Ferroptosis via Modulation of the Xc-/GSH/GPX4 Axis. [Abstract]

2026 Apr 3;48(4):375. PMID: 42042035
Front Biosci (Landmark Ed)

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence. [Abstract]

2026 Jan 31;31(2):48325. PMID: 41761985
Curr Issues Mol Biol

Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway. [Abstract]

2026 Jan 27;48(2):138. PMID: 41751402
J Trace Elem Med Biol

Iron dysregulation and ferroptosis are associated with pulmonary fibrosis: Insight from idiopathic pulmonary fibrosis, systemic sclerosis, and COVID-19 patients. [Abstract]

2025 Oct:91:127728. PMID: 40857901
BMC Cancer

The integration of transcriptomics and metabolomics elucidates the antitumor mechanisms of mycophenolic acid in bladder cancer cells. [Abstract]

2025 Sep 30;25(1):1463. PMID: 41029501
Front Biosci (Landmark Ed)

Immune Characteristics of eQTL and Gene Risk Model and the Inhibitory Effect of DCTD and RRAS on Ferroptosis in Glioblastoma. [Abstract]

2025 Aug 30;30(8):42844. PMID: 40917066
BMC Cancer

Platycodin D-mediated METTL16 downregulation promotes docetaxel treatment of prostate cancer by regulating ferroptosis. [Abstract]

2025 Jul 1;25(1):1042. PMID: 40597047
Front Biosci (Landmark Ed)

Scutellarin Attenuates Pro-Inflammatory Foam Cell Formation and Facilitates M2 Polarization in Microglia during Copper Homeostasis Imbalance via the MAPK Signaling Pathway. [Abstract]

2025 Mar 6;30(3):36255. PMID: 40152387
J Biol Chem

FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells. [Abstract]

2024 Sep;300(9):107678. PMID: 39151727
J Infect Dis

Role of Histiocyte-Derived frHMGB1 as a Facilitator in Non-Canonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis. [Abstract]

2024 Aug 16;230(2):298-308. PMID: 38243905
Front Biosci (Landmark Ed)

Leonurine Ameliorates Diabetic Nephropathy through GPX4-Mediated Ferroptosis of Endothelial Cells. [Abstract]

2024 Jul 25;29(7):270. PMID: 39082358
Lab Invest

MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2023 Aug;103(8):100180. PMID: 37230466
Front Biosci (Landmark Ed)

Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway. [Abstract]

2023 Mar 2;28(3):42. PMID: 37005755
J Biol Chem

Glucose-6-phosphate dehydrogenase exerts anti-stress effects independently of its enzymatic activity. [Abstract]

2022 Dec;298(12):102587. PMID: 36243112
Lab Invest

CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. [Abstract]

2022 Dec;102(12):1323-1334. PMID: 35945269
BMC Cancer

Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells. [Abstract]

2022 Jul 2;22(1):724. PMID: 35778693
ACS Pharmacol Transl Sci

Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway. [Abstract]

2026 Apr 3;9(5):1134-1152. PMID: 42130718
Naunyn Schmiedebergs Arch Pharmacol

Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine. [Abstract]

2025 Dec 18. PMID: 41408483
Naunyn Schmiedebergs Arch Pharmacol

Fucoidan induces ferroptosis in colorectal cancer cells by regulating the SLC7A11/GPX4 signaling pathway and modulating metabolic pathways. [Abstract]

2025 Oct 10. PMID: 41071315
Naunyn Schmiedebergs Arch Pharmacol

Gastrodin improves learning and memory in sleep-deprived mice through suppression of ferroptosis in hippocampal neurons via Nrf2. [Abstract]

2025 Aug 4. PMID: 40760051
Naunyn Schmiedebergs Arch Pharmacol

L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1. [Abstract]

2025 May 6. PMID: 40328913
Naunyn Schmiedebergs Arch Pharmacol

Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6. [Abstract]

2024 Nov;397(11):9111-9121. PMID: 38896272
Neurobiol Aging

Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis. [Abstract]

2024 Feb:134:115-125. PMID: 38056217
J Endocrinol Invest

CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma. [Abstract]

2023 Aug;46(8):1573-1587. PMID: 36853491
J Cell Physiol

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. [Abstract]

2021 Apr;236(4):2725-2739. PMID: 32892384
J Cell Physiol

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin. [Abstract]

2020 Apr;235(4):3425-3437. PMID: 31556117
J Cell Physiol

Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. [Abstract]

2020 Apr;235(4):3329-3339. PMID: 31541463
J Funct Foods

2025 Jun.
J Funct Foods

2025 Apr.
J Funct Foods

2024 Oct.
J Hepatocell Carcinoma

miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway. [Abstract]

2023 Dec 6:10:2173-2185. PMID: 38084209
Neurotox Res

NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11. [Abstract]

2023 Oct;41(5):398-407. PMID: 37060393
J Funct Foods

2023 May.

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2023 May.

Ferrostatin-1 (Fer-1) significantly restores the decreased cell viability in HK-1 and 5-8F cells induced by α-solanine.
Ren Fail

Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease. [Abstract]

2026 Dec;48(1):2667591. PMID: 42186424
Vet Res

GSK3β-mediated NRF2 degradation drives Escherichia coli-induced ferroptosis in the bovine endometrium. [Abstract]

2025 Dec 18;56(1):232. PMID: 41413615
Biochim Biophys Acta Mol Cell Biol Lipids

Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy. [Abstract]

2025 Oct 3;1871(1):159692. PMID: 41047095
J Orthop Surg Res

Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study. [Abstract]

2025 Oct 17;20(1):894. PMID: 41107894
Carcinogenesis

Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to ROS-induced cell death. [Abstract]

2025 Apr 3;46(2):bgaf027. PMID: 40458924
J Orthop Surg Res

Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia. [Abstract]

2025 Jan 23;20(1):83. PMID: 39849573
J Orthop Surg Res

Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis. [Abstract]

2023 Jul 21;18(1):518. PMID: 37480032
Mol Brain

Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells. [Abstract]

2022 Jun 20;15(1):57. PMID: 35725567
Viruses

Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. [Abstract]

2021 Nov 28;13(12):2383. PMID: 34960652
Pathol Res Pract

Salidroside exerts anti-cancer activity in lung adenocarcinoma by inducing ferroptosis through dual inhibition of the SLC7A11/cystine/GSH/GPX4 axis and the AKT/mTORC1/GPX4 pathway. [Abstract]

2026 Aug:284:156510. PMID: 42119357
Mol Immunol

Transcription factor STAT1 upregulates IL-36γ to mediate the sensitivity of human nasal epithelial cells to ferroptosis and promote inflammatory progression in chronic rhinosinusitis. [Abstract]

2026 Aug:196:11-23. PMID: 42247985
Pathol Res Pract

Effect of Ferrostatin-1 on temporomandibular joint synovitis induced by abnormal flow fluid shear stress: An in vitro study. [Abstract]

2026 Feb:278:156330. PMID: 41389633
Pathol Res Pract

Serine/arginine-rich splicing factor 1 inhibits ferroptosis and promotes glycolysis in endometrial cancer via activating mTOR and β-catenin. [Abstract]

2026 Mar:279:156364. PMID: 41564687
Pathol Res Pract

Integrating transcriptomics and machine learning to predict ferroptosis-related genes and analyzing the role of GOT1 in gastric cancer progression. [Abstract]

2025 Dec:276:156252. PMID: 41106221
Pathol Res Pract

FBXW7 promotes osteoarthritis injury by regulating SLC7A11 ubiquitination degradation and chondrocyte ferroptosis. [Abstract]

2026 Jan:277:156297. PMID: 41274067
J Med Virol

Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis. [Abstract]

2024 Oct;96(10):e29945. PMID: 39370874
J Pharm Pharmacol

Protopanaxadiol prevents cisplatin-induced acute kidney injury by regulating ferroptosis. [Abstract]

2024 Jul 5;76(7):884-896. PMID: 38708970
J Bioenerg Biomembr

Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis. [Abstract]

2024 Feb;56(1):31-44. PMID: 38012335
J Pharm Pharmacol

Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. [Abstract]

2023 Nov 23;75(11):1467-1477. PMID: 37738327
J Nat Prod

Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and in Vivo. [Abstract]

2022 Aug 26;85(8):2006-2017. PMID: 35976233
J Biochem Mol Toxicol

NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways. [Abstract]

2026 Apr;40(4):e70809. PMID: 41873218
J Biochem Mol Toxicol

SP1-Induced GLS2 Promotes Hypoxia/Reoxygenation-Induced AC16 Cell Injury by Regulating Ferroptosis Via an AMPK/mTOR Signaling Pathway. [Abstract]

2026 Mar;40(3):e70768. PMID: 41817959
Toxicol Appl Pharmacol

Nrf2-mediated inhibition of ferroptosis contributes to the amelioration of atherosclerosis by polydatin. [Abstract]

2025 Nov:504:117538. PMID: 40886948
Toxicol Appl Pharmacol

CDKN3 promoted triple-negative breast cancer by inhibiting ferroptosis through the upregulation of HSP90. [Abstract]

2026 Jan:506:117629. PMID: 41207514
J Biochem Mol Toxicol

Kaempferide Inhibits the Proliferation and Invasion and Induces Ferroptosis in Melanoma by Inactivating Wnt/β-Catenin Pathway. [Abstract]

2025 Oct;39(10):e70535. PMID: 41046540
Toxicol Appl Pharmacol

PM2.5 enhances DRP1-mediated mitochondrial fission to induce ferroptosis and exacerbate asthma through the AHR-HSP90-PKM2 pathway. [Abstract]

2025 Oct 4:505:117590. PMID: 41052681
J Biochem Mol Toxicol

Falcarindiol Suppresses Malignant Progression and Induces Ferroptosis in Non-Small Cell Lung Cancer by Regulating JAK/STAT3 Axis. [Abstract]

2025 Sep;39(9):e70486. PMID: 40901755
Toxicol Appl Pharmacol

Chrysin enhances sunitinib sensitivity in renal cell carcinoma by inducing ferroptosis via targeting PI3K/Akt/GPX4 pathway. [Abstract]

2025 Aug 21:117531. PMID: 40848919
PLoS Negl Trop Dis

Hepatic ferroptosis induced by Clonorchis sinensis exacerbates liver fibrosis. [Abstract]

2025 Jun 2;19(6):e0013164. PMID: 40455823
Curr Pharm Anal

2025 Mar.
Toxicol Appl Pharmacol

T-2 toxin triggers immunotoxic effects in goats by inducing ferroptosis and neutrophil extracellular traps. [Abstract]

2025 Feb:495:117232. PMID: 39832565
Toxicol Appl Pharmacol

Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway. [Abstract]

2024 Nov:492:117136. PMID: 39476876
J Food Qual

2024 Feb 7.
J Biochem Mol Toxicol

Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway. [Abstract]

2024 Jan;38(1):e23542. PMID: 37712196
Toxicol Appl Pharmacol

Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner. [Abstract]

2023 Apr 15:465:116452. PMID: 36894071
Front Med (Lausanne)

Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration. [Abstract]

2022 Jul 22:9:887062. PMID: 35935755
Toxicol Appl Pharmacol

A novel halogenated adenosine analog 5'-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro. [Abstract]

2022 Feb 1:436:115857. PMID: 34979143
Nanotoxicology

Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis. [Abstract]

2022 Nov-Dec;16(9-10):829-843. PMID: 36660964
Int J Parasitol Drugs Drug Resist

2026 Aug:31:100661. PMID: 42476011
Mol Carcinog

2026 Jun 30. PMID: 42378631
Photochem Photobiol Sci

DUSP1 deficiency accelerates UVB‑induced HDF cell senescence by regulating ferroptosis. [Abstract]

2026 Jun;25(6):1065-1077. PMID: 42080981
Exp Cell Res

Role of CIRP in glioma Progression: Inhibition of ferroptosis via UBR5-Mediated ACSL4 degradation. [Abstract]

2026 Apr 15;457(2):114942. PMID: 41687914
J Radiat Res Appl Sci

2026 Apr 16;19(2):102380.
Cell Biol Int

Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress. [Abstract]

2026 Mar;50(3):e70153. PMID: 41841014
Appl Biochem Biotechnol

Internal Heat Acupuncture Treatment Inhibits Ferroptosis in the Spinal Dorsal Horn in Neurotoxin-Induced Parkinson's Disease Rats. [Abstract]

2026 Mar 19. PMID: 41854854
Immun Inflamm Dis

Kaempferol Attenuates Oxidative Stress-Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis. [Abstract]

2026 Feb;14(2):e70352. PMID: 41684188
Appl Biochem Biotechnol

OGT Silencing Protects against Trophoblast Ferroptosis in Gestational Diabetes Mellitus Via ELP3 O-GlcNAcylation Suppression. [Abstract]

2026 Jan 8. PMID: 41504842
Appl Biochem Biotechnol

Mechanistic Study of S100A8-mediated Ferroptosis in Vascular Dementia Through the JAK2/STAT3 Pathway. [Abstract]

2026 Jan 15. PMID: 41538098
Int J Biochem Cell Biol

Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis. [Abstract]

2025 Dec:189:106866. PMID: 40998236
Arch Biochem Biophys

Inhibition of ferroptosis by serine protease inhibitor attenuates acute respiratory distress syndrome. [Abstract]

2025 Nov:773:110596. PMID: 40849045
Exp Cell Res

PERK suppression induces susceptibility to ferroptosis in lupus nephritis. [Abstract]

2025 Aug 25;452(1):114725. PMID: 40865630
Cardiovasc Drugs Ther

ALKBH5 Regulates Inflammation and Pyroptosis of Coronary Heart Disease by Targeting SPEN in a YTHDF1-Mediated Manner. [Abstract]

2025 Jul 26. PMID: 40715613
Cell Biol Int

Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis. [Abstract]

2025 Mar 24. PMID: 40126008
Mol Carcinog

KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance. [Abstract]

2025 Jul 24. PMID: 40705827
Arch Biochem Biophys

Role of protein disulfide isomerase in mediating sulfasalazine-induced ferroptosis in HT22 cells: The PDI-NOS-NO-ROS/lipid-ROS cascade. [Abstract]

2025 Jun:768:110366. PMID: 40023379
Appl Biochem Biotechnol

6-Gingerol Inhibits Ferroptosis in Endothelial Cells in Atherosclerosis by Activating the NRF2/HO-1 Pathway. [Abstract]

2025 Mar 22. PMID: 40120045
ChemMedChem

Elucidating the High Affinity Copper(II) Complexation by the Iron Chelator Deferasirox Provides Therapeutic and Toxicity Insight. [Abstract]

2025 Apr 1;20(7):e202400937. PMID: 39714988
Photochem Photobiol Sci

UVB irradiation induces melanocyte damage through ferroptosis: mechanisms and implications. [Abstract]

2025 Apr 11. PMID: 40216658
Photochem Photobiol Sci

TIMP3 deficiency accelerates UVB-induced HaCaT cell senescence by regulating ferroptosis. [Abstract]

2025 Mar;24(3):499-509. PMID: 40117061
Arch Biochem Biophys

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway. [Abstract]

2025 Mar:765:110316. PMID: 39848420
Exp Cell Res

Silencing of LOX-1 attenuates high glucose-induced ferroptosis in THVECs via the HIF-1α/SLC7A11 signaling pathway. [Abstract]

2025 Mar 15;446(2):114451. PMID: 40015503
Arch Biochem Biophys

Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells. [Abstract]

2024 Nov:761:110188. PMID: 39490616
Exp Cell Res

Sensitivity of triple negative breast cancer cells to ATM-dependent ferroptosis induced by sodium selenite. [Abstract]

2024 Oct 1;442(2):114222. PMID: 39214329
Exp Cell Res

Palmitic acid induces β-cell ferroptosis by activating ceramide signaling pathway. [Abstract]

2024 Jul 15;440(2):114134. PMID: 38901790
Exp Cell Res

AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4. [Abstract]

2024 May 11;439(1):114087. PMID: 38735619
Arch Biochem Biophys

Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy. [Abstract]

2024 Mar:753:109905. PMID: 38281543
Cell Biol Int

Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR-1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer. [Abstract]

2023 Nov;47(11):1813-1824. PMID: 37471707
Arch Biochem Biophys

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. [Abstract]

2023 Aug:744:109691. PMID: 37473980
Mol Carcinog

PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. [Abstract]

2023 Aug;62(8):1119-1135. PMID: 37144835
Arch Biochem Biophys

Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway. [Abstract]

2023 Jul 1:742:109622. PMID: 37172672
Arch Biochem Biophys

PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori related gastric cancer. [Abstract]

2023 May 15:740:109560. PMID: 36948350
Arch Biochem Biophys

ESR1 inhibits ionizing radiation-induced ferroptosis in breast cancer cells via the NEDD4L/CD71 pathway. [Abstract]

2022 Aug 15:725:109299. PMID: 35613689
Arch Biochem Biophys

FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis. [Abstract]

2022 Jun 15;722:109216. PMID: 35421356
Mol Cell Endocrinol

EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1. [Abstract]

2026 Mar:613:112721. PMID: 41422938
Reproduction

Fibroblast growth factor 21 attenuates FSH-induced ferroptosis in TM4 Sertoli cells. [Abstract]

2026 Feb 5;171(2):xaag001. PMID: 41575507
Nat Sci Sleep

The Role of Ferroptosis in Adenoid Hypertrophy in Children with Obstructive Sleep Apnea Syndrome. [Abstract]

2025 Dec 18:17:3167-3180. PMID: 41439202
J Cancer

SREBP1-SCD1 enhanced MUFAs Biosynthesis drives Nutrient Deprived Pancreatic cancer cell Ferroptosis Resistance. [Abstract]

2025 Sep 8;16(13):3960-3971. PMID: 41049011
Reproduction

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner. [Abstract]

2025 Sep 19;170(4):e250251. PMID: 40911580
Front Oncol

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation. [Abstract]

2025 Jun 24:15:1584811. PMID: 40630211
J Cancer

Resveratrol Induces Oxidative Stress and Downregulates GPX4 and xCT to Activate the Ferroptosis Pathway for Anti-Bladder Cancer Organoids. [Abstract]

2025 Jun 9;16(8):2613-2625. PMID: 40535803
J Neurorestoratology

2024 Nov 27.
Exp Dermatol

Ferrostatin 1 ameliorates UVB-induced damage of HaCaT cells by regulating ferroptosis. [Abstract]

2024 Feb;33(2):e15018. PMID: 38414007
J Neurooncol

Engineered Salmonella inhibits GPX4 expression and induces ferroptosis to suppress glioma growth in vitro and in vivo. [Abstract]

2023 Jul;163(3):607-622. PMID: 37351767
J Cancer

PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis. [Abstract]

2023 May 15;14(8):1336-1349. PMID: 37283787
Andrology

Ferroptosis is involved in corpus cavernosum smooth muscle cells impairment in diabetes mellitus-induced erectile dysfunction. [Abstract]

2023 Feb;11(2):332-343. PMID: 36098277
Front Oncol

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma. [Abstract]

2022 May 18:12:874900. PMID: 35664792
Atheroscler Plus

Circular RNA expression profile of H2O2 induced ferroptosis model of human coronary artery endothelial cells. [Abstract]

2022 May 6:49:1-11. PMID: 36644200
Front Oncol

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib. [Abstract]

2020 Dec 23:10:597434. PMID: 33425751
Cardiovasc Toxicol

2026 Jul 24;26(8):87. PMID: 42496814
J Integr Neurosci

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury. [Abstract]

2026 May 26;25(5):48011. PMID: 42216635
Cardiovasc Toxicol

Quercetin Antagonizes Doxorubicin-Induced Cardiotoxicity via HO-1/PGC-1α-ALOX5 Axis: Arachidonic Acid Metabolism-Ferroptosis Crosstalk as a Therapeutic Target. [Abstract]

2026 May 13;26(5):48. PMID: 42126728
J Cancer Res Clin Oncol

Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma. [Abstract]

2026 Mar 5;152(3):59. PMID: 41787198
Diabet Med

m6A demethylase ALKBH5 reduces ferroptosis in diabetic retinopathy through the m6A-YTHDF1-ACSL4 axis. [Abstract]

2025 Aug;42(8):e70033. PMID: 40210448
Biochem Biophys Rep

Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT/enhancer-binding protein homologous protein. [Abstract]

2025 Jul 7:43:102143. PMID: 40688501
J Cancer Res Clin Oncol

Depletion of UBAP2L suppresses colorectal cancer cell proliferation and radiotherapy resistance by regulating GPX4. [Abstract]

2025 Jul 15;151(7):214. PMID: 40665007
Cardiovasc Toxicol

HIPK2 Confers Protection Against Septic Myocardial Injury by Regulating Ferroptosis. [Abstract]

2025 Jul 28. PMID: 40721557
Chem Biol Drug Des

Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway. [Abstract]

2025 Mar;105(3):e70071. PMID: 40070232
Chem Biol Drug Des

Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis. [Abstract]

2025 Feb;105(2):e70053. PMID: 39871642
J Cancer Res Clin Oncol

Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4. [Abstract]

2024 Sep 23;150(9):429. PMID: 39311951
Chem Biol Drug Des

Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation. [Abstract]

2024 Aug;104(2):e14560. PMID: 39175059
Chem Biol Drug Des

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3. [Abstract]

2024 Jun;103(6):e14565. PMID: 38862254
Animals (Basel)

Forsythiaside A Alleviates LPS-Induced Mastitis by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Jun 5;16(11):1750. PMID: 42278181
Animals (Basel)

Mechanism of Liver Injury Induced by Cr6+ in Zebrafish and Protective Effect of Selenomethionine. [Abstract]

2026 Feb 22;16(4):687. PMID: 41751148
Infect Drug Resist

Hydroxysafflor Yellow A Mitigates Sepsis-Induced Pulmonary and Intestinal Injury by Inhibiting TP53 Mediated Ferroptosis. [Abstract]

2025 Dec 8:18:6427-6450. PMID: 41394332
Brain Res

Silencing of METTL14 attenuates experimental intracerebral hemorrhage by suppressing TFRC-mediated ferroptosis. [Abstract]

2025 Nov 1:1866:149927. PMID: 40907591
J Phys D Appl Phys

2025 Nov 13.
Food Chem Toxicol

Osthole inhibits proliferation and induces autophagy-dependent ferroptosis of cervical cancer cells through induction of TFR1. [Abstract]

2025 Sep:203:115577. PMID: 40446951
Mol Biotechnol

METTL14 Hinders DCM Progression via Mediating the m6A Methylation of NRG4 in HG-Induced H9C2 Cells. [Abstract]

2025 Sep 2. PMID: 40892366
IUBMB Life

Contrast-Induced Acute Kidney Injury is Modulated by Circadian CLOCK/NRF2 Pathway. [Abstract]

2025 May;77(5):e70022. PMID: 40391788
Food Chem Toxicol

Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung. [Abstract]

2025 Apr:198:115324. PMID: 39954982
Mol Biol Rep

GNF-5837 attenuates acute liver injury by inhibiting oxidative stress. [Abstract]

2025 Apr 21;52(1):407. PMID: 40257700
J Therm Biol

Hot air injures human alveolar epithelial cells through ERK1/2 signaling-mediated ferroptosis. [Abstract]

2025 Jan:127:104065. PMID: 39893824
BMC Gastroenterol

Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer. [Abstract]

2025 Jan 30;25(1):46. PMID: 39885392
Animals (Basel)

Transcriptome and Proteome Analyses Revealed Differences in JEV-Infected PK-15 Cells in Response to Ferroptosis Agonists and Antagonists. [Abstract]

2024 Dec 5;14(23):3516. PMID: 39682481
Brain Res

Nicotinamide mononucleotide mitigates neuroinflammation by enhancing GPX4-mediated ferroptosis defense in microglia. [Abstract]

2024 Dec 15:1845:149197. PMID: 39216693
Food Chem Toxicol

Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo. [Abstract]

2024 Oct:192:114926. PMID: 39147356
Amino Acids

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma. [Abstract]

2024 Sep 30;56(1):57. PMID: 39343853
Mol Biotechnol

Verteporfin Exerts Anticancer Effects and Reverses Resistance to Paclitaxel via Inducing Ferroptosis in Esophageal Squamous Cell Cancer Cells. [Abstract]

2024 Sep;66(9):2558-2568. PMID: 37751128
Surgery

CPT1B maintains redox homeostasis and inhibits ferroptosis to induce gemcitabine resistance via the KEAP1/NRF2 axis in pancreatic cancer. [Abstract]

2024 May;175(5):1264-1275. PMID: 38302326
Food Chem Toxicol

Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis. [Abstract]

2024 Feb:184:114385. PMID: 38123054
Neuropsychiatr Dis Treat

Ferulic Acid Activates SIRT1-Mediated Ferroptosis Signaling Pathway to Improve Cognition Dysfunction in Wilson's Disease. [Abstract]

2023 Dec 5:19:2681-2696. PMID: 38077239
Food Chem Toxicol

Mitophagy contributes to zinc-induced ferroptosis in porcine testis cells. [Abstract]

2023 Sep:179:113950. PMID: 37481227
Food Chem Toxicol

Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. [Abstract]

2022 Aug:166:113255. PMID: 35772596
J Immunol Res

CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53. [Abstract]

2022 Aug 25:2022:2527210. PMID: 36061308
Tissue Cell

Ablation of ASF1B mitigates the proliferation of A549 cells and enhances anti-PD-L1 therapy by regulating ferroptosis. [Abstract]

2026 May 8:102:103584. PMID: 42114389
Exp Eye Res

SREBP1-driven SCD1 protects retinal pigment epithelium from oxidative damage by activating the NRF2/GPX4 axis. [Abstract]

2026 May:266:110932. PMID: 41720386
Chin J Integr Med

Platycodin D Overcomes Cisplatin Resistance in Gastric Cancer by Inducing Ferroptosis through TLK1-Dependent UHRF2/DNMT3A/ALOX15 Pathway. [Abstract]

2026 May 18. PMID: 42149324
Tissue Cell

Ano5 deficiency inhibits osteoclastogenesis and reduces ovariectomy-induced bone loss by regulating the ACSL4-dependent ferroptosis pathway. [Abstract]

2026 May 28:103:103635. PMID: 42229282
Tissue Cell

Glutaredoxin 1 promotes sorafenib resistance in renal cell carcinoma through ferroptosis suppression: Integrative bioinformatics analysis and experimental validation. [Abstract]

2026 Apr 9:102:103518. PMID: 41990693
Free Radic Res

Molecular mechanism of METTL7B-mediated m6A modification in ferroptosis of non-small cell lung cancer cells. [Abstract]

2026 Feb;60(2):157-168. PMID: 41652972
Kaohsiung J Med Sci

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway. [Abstract]

2026 Feb 4:e70175. PMID: 41636120
Cell Tissue Res

Phenothiazine alleviates cisplatin-mediated acute kidney injury by inhibiting ferroptosis. [Abstract]

2026 Jan 23;403(1):12. PMID: 41575591
Tissue Cell

ELAVL1 promotes ferroptosis-induced inhibition of osteogenic differentiation in diabetic osteoporosis by downregulating SIRT1. [Abstract]

2025 Dec:97:103060. PMID: 40753732
Tissue Cell

USP7 represses ferroptosis in trophoblasts in pre-eclampsia by mediating the xCT/GPX4 axis via deubiquitination of NRF2. [Abstract]

2025 Dec:97:103050. PMID: 40774093
3 Biotech

Rosmarinic acid induces ferroptosis in colon cancer: insights from AKR1C3/PTGS2 pathway and mitochondrial dysfunction. [Abstract]

2025 Nov;15(11):374. PMID: 41064160
J Inorg Biochem

Iridium(III) complexes as type I photosensitizers for hypoxic two-photon photodynamic therapy. [Abstract]

2025 Nov:272:113006. PMID: 40682924
Tissue Cell

Tempol suppresses ferroptosis and relieves chronic intermittent hypoxia-induced lung injury through the inhibition of TLR4 and activation of the Nrf2/GSH axis. [Abstract]

2026 Feb:98:103225. PMID: 41232311
Kaohsiung J Med Sci

Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β-Catenin Pathway. [Abstract]

2025 Nov 13:e70123. PMID: 41229334
Free Radic Res

Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson's disease. [Abstract]

2025 Oct-Dec;59(10-12):797-814. PMID: 41273307
Kaohsiung J Med Sci

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma via NF-κB Inactivation. [Abstract]

2025 Oct 1:e70110. PMID: 41031478
J Appl Toxicol

The Role of the p62-Keap1-Nrf2 Pathway in Protecting Sertoli Cells Against Mono-(2-ethylhexyl)phthalate-induced Ferroptosis. [Abstract]

2025 Oct 12. PMID: 41077046
Exp Eye Res

Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications. [Abstract]

2025 Oct:259:110531. PMID: 40701537
Tissue Cell

Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation. [Abstract]

2025 Sep 18:98:103141. PMID: 40992258
Tissue Cell

The interplay of sleep deprivation, ferroptosis, and BACH1 in cardiovascular disease pathogenesis. [Abstract]

2025 Aug:95:102848. PMID: 40081254
J Appl Toxicol

Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways. [Abstract]

2025 Aug;45(8):1637-1648. PMID: 40288885
Free Radic Res

Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis. [Abstract]

2025 May;59(5):426-441. PMID: 40460255
Free Radic Res

Metformin ameliorates gestational diabetes mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathway. [Abstract]

2025 Feb;59(2):190-203. PMID: 39959960
BMC Cardiovasc Disord

Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation. [Abstract]

2025 Jan 10;25(1):16. PMID: 39794696
Placenta

Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB/HO-1 pathway. [Abstract]

2024 Dec:158:145-155. PMID: 39490110
Free Radic Res

Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice. [Abstract]

2024 Nov;58(11):733-747. PMID: 39514464
Kaohsiung J Med Sci

CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination. [Abstract]

2024 Oct;40(10):890-902. PMID: 39166861
Kaohsiung J Med Sci

HMGB1 inhibition blocks ferroptosis and oxidative stress to ameliorate sepsis-induced acute lung injury by activating the Nrf2 pathway. [Abstract]

2024 Aug;40(8):710-721. PMID: 38837857
J Appl Toxicol

Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response. [Abstract]

2024 Aug;44(8):1139-1152. PMID: 38581191
Hum Mol Genet

PSMC5 insufficiency and P320R mutation impair proteasome function. [Abstract]

2024 Aug 18;33(17):1506-1523. PMID: 38776958
J Proteomics

SRSF1 inhibits ferroptosis and reduces cisplatin chemosensitivity of triple-negative breast cancer cells through the circSEPT9/GCH1 axis. [Abstract]

2024 Feb 10:292:105055. PMID: 38040194
Integr Cancer Ther

Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway. [Abstract]

2023 Jan-Dec:22:15347354231210867. PMID: 37965730
Am J Cancer Res

LINC02362/hsa-miR-18a-5p/FDX1 axis suppresses proliferation and drives cuproptosis and oxaliplatin sensitivity of hepatocellular carcinoma. [Abstract]

2023 Nov 15;13(11):5590-5609. PMID: 38058825
Exp Eye Res

Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway. [Abstract]

2023 Sep:234:109569. PMID: 37422064
Kaohsiung J Med Sci

Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis. [Abstract]

2023 Jul;39(7):699-709. PMID: 37057810
Am J Cancer Res

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy. [Abstract]

2023 Feb 15;13(2):464-474. PMID: 36895980
Kaohsiung J Med Sci

MiR-199a-5p promotes ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reperfusion injury via inhibiting Akt/eNOS signaling pathway. [Abstract]

2022 Nov;38(11):1093-1102. PMID: 36254861
Immunopharmacol Immunotoxicol

Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK/NF-κB pathway. [Abstract]

2022 Aug;44(4):621-631. PMID: 35486494
Yonsei Med J

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells. [Abstract]

2021 Sep;62(9):843-849. PMID: 34427071
Cell Biochem Biophys

2026 Jul 13. PMID: 42440245
Hear Res

Screening a library of oxygen-containing potential natural molecular drugs for mitigating hearing loss with mechanistic envision. [Abstract]

2026 Mar:473:109570. PMID: 41719777
J Gene Med

Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways. [Abstract]

2025 Feb;27(2):e70011. PMID: 39965807
J Gene Med

Dipeptidyl peptidase 4: A predictor of ferroptosis in ulcerative colitis. [Abstract]

2024 Oct;26(10):e3742. PMID: 39343840
Front Cardiovasc Med

Lipocalin-2 in neutrophils induces ferroptosis in septic cardiac dysfunction via increasing labile iron pool of cardiomyocytes. [Abstract]

2022 Aug 4;9:922534. PMID: 35990970
Front Cardiovasc Med

miR-135b-3p Promotes Cardiomyocyte Ferroptosis by Targeting GPX4 and Aggravates Myocardial Ischemia/Reperfusion Injury. [Abstract]

2021 Aug 13;8:663832. PMID: 34485394
Theriogenology

Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak. [Abstract]

2026 Sep 1:261:117946. PMID: 42008865
Chem Biodivers

Rhein-Emodin Combination Activates UQCRC1 to Attenuate MPP+-Induced Ferroptosis in Dopaminergic Neurons. [Abstract]

2026 Mar;23(3):e02053. PMID: 41838561
PeerJ

Lactotransferrin upregulation affects the pathological changes of non-small cell lung cancer by regulating ferroptosis. [Abstract]

2026 Feb 27:14:e20866. PMID: 41777684
Acta Histochem

POSTN promotes ferroptosis and contributes to the pathogenesis of IgA nephropathy via GPX4 downregulation. [Abstract]

2025 Dec;127(4):152296. PMID: 41202667
IBRO Neurosci Rep

Fer-1 alleviates traumatic brain injury-induced cognitive impairment by inhibiting hippocampal ferroptosis. [Abstract]

2025 Oct 25:19:821-830. PMID: 41234438
IBRO Neurosci Rep

Celastrol alleviates secondary brain injury following intracerebral haemorrhage by inhibiting neuronal ferroptosis and blocking blood-brain barrier disruption. [Abstract]

2024 Aug 6:17:161-176. PMID: 39220228
PeerJ

Mesenchymal stem cells alleviate sepsis-induced acute lung injury by blocking neutrophil extracellular traps formation and inhibiting ferroptosis in rats. [Abstract]

2024 Jan 29:12:e16748. PMID: 38304189
Biomed Res Int

Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity. [Abstract]

2022 Jul 18:2022:5623555. PMID: 36060128
PLoS One

PTPRE promotes gastric cancer cell resistance to 5-fluorouracil by inhibiting ferroptosis via the Src/FAK/TRIB3 axis. [Abstract]

2026 Jun 18;21(6):e0351846. PMID: 42313735
Int J Immunopathol Pharmacol

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells. [Abstract]

2026 Jan-Dec:40:3946320261427239. PMID: 41747744
PLoS One

Grape seed proanthocyanidin extract inhibits ferroptosis by activating Nrf2/HO-1 and protects against diabetic kidney disease. [Abstract]

2025 Dec 11;20(12):e0336472. PMID: 41379777
Discov Oncol

Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling. [Abstract]

2025 Nov 7;16(1):2053. PMID: 41201718
Hum Cell

Long non-coding RNA FEZF1-AS1 suppresses ferroptosis in multiple myeloma cells through KIAA1429-mediated m6A modification. [Abstract]

2025 Oct 14;38(6):178. PMID: 41085851
Hum Cell

Multi-omic analysis constructs ferroptosis subtypes and risk signature and reveals that PEBP1 is an important tumor suppressor in kidney cancer. [Abstract]

2025 Oct 6;38(6):173. PMID: 41053452
Hum Cell

CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia. [Abstract]

2025 Jul 3;38(5):123. PMID: 40608154
Discov Oncol

Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway. [Abstract]

2025 Jun 2;16(1):983. PMID: 40451984
PLoS One

Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells. [Abstract]

2025 May 22;20(5):e0322746. PMID: 40402956
Discov Oncol

Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway. [Abstract]

2025 May 15;16(1):772. PMID: 40372576
Vet Microbiol

Autophagy is involved in Salmonella Typhimurium-induced ferroptosis in macrophages. [Abstract]

2025 Apr 27:305:110538. PMID: 40311251
Genesis

Generation of Myeloid-Specific Bmal1 Knockout Mice and Identification of Bmal1-Regulated Ferroptosis in Macrophages. [Abstract]

2025 Apr;63(2):e70014. PMID: 40197722
Toxicon

Ursolic acid enhances radiosensitivity in esophageal squamous cell carcinoma by modulating p53/SLC7A11/GPX4 pathway-mediated ferroptosis. [Abstract]

2025 Feb:255:108233. PMID: 39788329
Curr Microbiol

Screening of Regulatory mRNAs and miRNAs that Suppress Staphylococcus aureus Proliferation via Macrophage Ferroptosis. [Abstract]

2025 Feb 11;82(4):133. PMID: 39932559
J Assist Reprod Genet

Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss. [Abstract]

2024 Jun;41(6):1669-1685. PMID: 38526774
Toxicon

β-eudesmol inhibits cell proliferation and induces ferroptosis via regulating MAPK signaling pathway in breast cancer. [Abstract]

2024 Jan:237:107529. PMID: 38030095
Dig Dis Sci

Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury. [Abstract]

2023 Nov;68(11):4196-4211. PMID: 37707747
J Pharmacol Sci

Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells. [Abstract]

2022 Mar;148(3):300-306. PMID: 35177209
Clin Rheumatol

2026 Jul 9. PMID: 42423821
Photodiagnosis Photodyn Ther

Ferroptosis promotes 5-aminolevulinate acid-based photodynamic therapy in cervical cancer. [Abstract]

2025 Aug:54:104726. PMID: 40680910
Fundam Clin Pharmacol

Knockdown of RFC3 enhances the sensitivity of colon cancer cells to oxaliplatin by inducing ferroptosis. [Abstract]

2025 Feb;39(1):e13044. PMID: 39749364
Photodiagnosis Photodyn Ther

5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4. [Abstract]

2023 Jun:42:103612. PMID: 37220842
J Dig Dis

AMPK activation alleviated DSS-induced colitis by inhibiting ferroptosis. [Abstract]

2023 Mar;24(3):213-223. PMID: 37210607
FEBS Open Bio

Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells. [Abstract]

2022 Jun;12(6):1197-1205. PMID: 35258176
FEBS Open Bio

Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer. [Abstract]

2022 Jan;12(1):146-153. PMID: 34644456
J Mol Histol

HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis. [Abstract]

2026 Jun 8;57(3):190. PMID: 42257786
BMC Med Genomics

CSTA and DDX24: potential biomarkers regulating ferroptosis in sepsis and their diagnostic value. [Abstract]

2026 Apr 9;19(1):78. PMID: 41952180
Pharmacol Res Perspect

Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells. [Abstract]

2026 Feb;14(1):e70213. PMID: 41445272
Burns

Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation. [Abstract]

2026 Jan 19;52(2):107872. PMID: 41579448
J Mol Histol

APMAP regulated by YY1 transcription mediates ferroptosis and metastasis in non-small cell lung cancer through the PI3K/AKT/mTOR pathway. [Abstract]

2026 Jan 7;57(1):27. PMID: 41495322
Hereditas

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis. [Abstract]

2025 Nov 4;162(1):223. PMID: 41188993
J Cardiovasc Transl Res

Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation. [Abstract]

2025 Sep 8. PMID: 40920282
J Mol Histol

The effect of USP17 knockdown on autophagic ferroptosis in gastric cancer by regulating the BNIP3-NCOA4-FTH1 axis. [Abstract]

2025 Jul 31;56(4):245. PMID: 40742478
J Mol Histol

Decoding phillygenin's dual attack on breast cancer: ferroptosis induction and immune evasion suppression. [Abstract]

2025 Jul 22;56(4):234. PMID: 40694249
Clin Med Insights Oncol

MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. [Abstract]

2024 Apr 15:18:11795549241244783. PMID: 38628842
Urolithiasis

STUB1 exacerbates calcium oxalate-induced kidney injury by modulating reactive oxygen species-mediated cellular autophagy via regulating CFTR ubiquitination. [Abstract]

2024 Apr 2;52(1):55. PMID: 38564006
Cartilage

Ferroptosis Plays a Role in Human Chondrocyte of Osteoarthritis Induced by IL-1β In Vitro. [Abstract]

2023 Dec;14(4):455-466. PMID: 36786219
DNA Cell Biol

ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2023 Jun;42(6):336-347. PMID: 37126948
DNA Cell Biol

The Knockdown of ETV4 Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon SLC7A11 Downregulation. [Abstract]

2021 Sep;40(9):1211-1221. PMID: 34283663
Biochem Biophys Res Commun

2026 Sep 10:830:154254. PMID: 42424934
Biochem Biophys Res Commun

Protection by maslinic acid against cisplatin-induced ototoxicity: rescue of ferroptosis by targeting the SLC7A11-GSH-GPX4 pathway. [Abstract]

2026 Apr 16:809:153480. PMID: 41722247
J Chromatogr B Analyt Technol Biomed Life Sci

Deficiency in beclin1 alleviates doxorubicin-induced liver injury through inhibiting ferroptosis and autophagy. [Abstract]

2026 Apr 15:1274:124971. PMID: 41707439
Reprod Biol

Epimedium polysaccharide alleviates adenine-induced oligoasthenozoospermia in mice by inhibiting ferroptosis and inflammation through TLR4/NF-κB and SLC7A11/GPX4 axis. [Abstract]

2026 Mar 10;26(2):101203. PMID: 41812369
Biochem Biophys Res Commun

Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis. [Abstract]

2026 Feb 12:800:153270. PMID: 41529459
Biochem Biophys Res Commun

Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway. [Abstract]

2026 Mar 12:804:153353. PMID: 41619504
Biochem Biophys Res Commun

Isoquercitrin inhibits ferroptosis and ameliorates insulin resistance: Evidence from network pharmacology and in vitro studies. [Abstract]

2025 Sep 25:781:152500. PMID: 40858065
Biochem Biophys Res Commun

Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis. [Abstract]

2025 Sep 1:777:152330. PMID: 40652815
Biochem Biophys Res Commun

Engineered MAP30ER: A plant toxin-derived platform for EGFR-Targeted delivery of protein and chemotherapeutic payloads. [Abstract]

2025 Aug 30:776:152184. PMID: 40517671
Biochem Biophys Res Commun

KLF15 prevents ferroptosis in vascular smooth muscle cells via interacting with p53. [Abstract]

2025 Jul 12:770:152029. PMID: 40382847
Biochem Biophys Res Commun

Network pharmacology, molecular docking and experimental study on the mechanism of Curcumin's anti-ferroptosis in melanocytes. [Abstract]

2024 Dec 3:736:150871. PMID: 39461013
Korean J Physiol Pharmacol

Salidroside attenuates sepsis-induced acute lung injury by inhibiting ferroptosis-dependent pathway. [Abstract]

2024 Nov 1;28(6):549-558. PMID: 39467718
Biochem Biophys Res Commun

Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis. [Abstract]

2024 Nov 12:733:150716. PMID: 39321486
Biochem Biophys Res Commun

S-Allyl-L-cysteine (SAC) inhibits copper-induced apoptosis and cuproptosis to alleviate cardiomyocyte injury. [Abstract]

2024 Oct 20:730:150341. PMID: 39018965
Cancer Chemother Pharmacol

A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro. [Abstract]

2024 Aug;94(2):183-195. PMID: 38536443
Biochem Biophys Res Commun

Hederagenin promotes lung cancer cell death by activating CHAC1-dependent ferroptosis pathway. [Abstract]

2024 Jul 23:718:150085. PMID: 38735142
Biochem Biophys Res Commun

The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway. [Abstract]

2024 May 14:708:149788. PMID: 38518720
Biochem Biophys Res Commun

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. [Abstract]

2024 May 28:710:149895. PMID: 38593620
Clin Cosmet Investig Dermatol

Variation of Ferroptosis-Related Markers in HaCaT Cell Photoaging Models Induced by UVB. [Abstract]

2023 Nov 1:16:3147-3155. PMID: 37937317
Biochem Biophys Res Commun

Gigantol exerts anti-lung cancer activity by inducing ferroptosis via SLC7A11-GPX4 axis. [Abstract]

2024 Jan 1:690:149274. PMID: 37995455
Biochem Biophys Res Commun

2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis. [Abstract]

2023 Oct 30:679:15-22. PMID: 37659274
Clin Exp Pharmacol Physiol

Moxibustion ameliorates cerebral ischemia-reperfusion injury by regulating ferroptosis in rats. [Abstract]

2023 Oct;50(10):779-788. PMID: 37417429
Biochem Biophys Res Commun

Hydrogen peroxide and iron ions can modulate lipid peroxidation, apoptosis, and the cell cycle, but do not have a significant effect on DNA double-strand break. [Abstract]

2023 Apr 9:651:121-126. PMID: 36822125
Biochem Biophys Res Commun

ACSL4 is overexpressed in psoriasis and enhances inflammatory responses by activating ferroptosis. [Abstract]

2022 Oct 1:623:1-8. PMID: 35868067
Biochem Biophys Res Commun

TMEM189 promotes breast cancer through inhibition of autophagy-regulated ferroptosis. [Abstract]

2022 Sep 24:622:37-44. PMID: 35843092
Biochem Biophys Res Commun

Ferroptosis in brain microvascular endothelial cells mediates blood-brain barrier disruption after traumatic brain injury. [Abstract]

2022 Sep 3:619:34-41. PMID: 35728282
Biochem Biophys Res Commun

Atorvastatin treatment ameliorates cardiac function and remodeling induced by isoproterenol attack through mitigation of ferroptosis. [Abstract]

2021 Oct 15:574:39-47. PMID: 34438345
Biochem Biophys Res Commun

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. [Abstract]

2019 Nov 12;519(3):533-539. PMID: 31537387
Onco Targets Ther

Aloperine Induces Ferroptosis of Colorectal Cancer Cells via the Nrf2 Pathway. [Abstract]

2026 Mar 21:19:575500. PMID: 41889434
Radiat Res

Fludarabine Enhances Radiosensitivity by Promoting Ferroptosis in B-Cell Lymphoma. [Abstract]

2024 Mar 1;201(3):224-239. PMID: 38235545
Sleep Breath

Nrf2 plays protective role during intermittent hypoxia-induced ferroptosis in rat liver (BRL-3A) cells. [Abstract]

2023 Oct;27(5):2069-2076. PMID: 36856923

Ferrostatin-1 purchased from MedChemExpress. Usage Cited in: Sleep Breath. 2023 Oct;27(5):2069-2076. [Abstract]

The protein content of GPX4 and FTH1 is signifcantly upregulated in intermittent hypoxia (IH)+ferrostatin-1 (5 μM) group, in rat liver (BRL‑3A) cells.
Sleep Breath

The role of ferroptosis and endoplasmic reticulum stress in intermittent hypoxia-induced myocardial injury. [Abstract]

2023 Jun;27(3):1005-1011. PMID: 35951213
Arch Oral Biol

Porphyromonas gingivalis lipopolysaccharide increases blood-brain barrier permeability via ferroptosis. [Abstract]

2026 Jul 24:191:106700. PMID: 42546472
J Oral Pathol Med

Panax notoginseng Saponins Alleviate OSF by Inhibiting Ferroptosis Through GPX4 Activation. [Abstract]

2025 Oct 9. PMID: 41064872
Ann Hematol

Increased ferroptosis of erythrocytes is associated with myelodysplastic syndromes. [Abstract]

2024 Oct;103(10):4009-4020. PMID: 39177794
Int J Gen Med

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway. [Abstract]

2024 Aug 24:17:3673-3687. PMID: 39206267
Cytotechnology

Liquid-liquid phase separation of TRIM21 regulates EZH2-mediated ferroptosis to facilitate hepatocellular carcinoma progression. [Abstract]

2026 Jun;78(3):100. PMID: 42079301
Cytotechnology

TRIM21 promotes colorectal cancer malignancy by coupling USP4/TGF-β signaling to ferroptosis-related homeostasis. [Abstract]

2026 Apr;78(2):65. PMID: 41868708
J Ocul Pharmacol Ther

Autologous Serum from Sjögren's Syndrome Patients Mitigates Ferroptosis in Hyperosmolarity-Induced Corneal Epitheliopathy. [Abstract]

2025 Jun 11. PMID: 40495717
Exp Ther Med

Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis‑related genes. [Abstract]

2024 Mar 22;27(5):221. PMID: 38590563
Exp Ther Med

Role of dysregulated ferroptosis‑related genes in cardiomyocyte ischemia‑reperfusion injury: Experimental verification and bioinformatics analysis. [Abstract]

2023 Sep 28;26(5):534. PMID: 37869642
Neurosci Lett

Ferrostatin-1 Ameliorates Bupivacaine-Induced Spinal Neurotoxicity in rats by Inhibiting Ferroptosis. [Abstract]

2023 Jul 13:809:137308. PMID: 37244447
Exp Ther Med

ChaC glutathione specific γ-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis. [Abstract]

2021 Sep;22(3):997. PMID: 34345279
Transl Cancer Res

2026 Jun 30;15(6):455. PMID: 42445428
Oncol Lett

Leucovorin enhances curcumin-induced inhibition of cell viability and ferroptosis in colorectal cancer cells. [Abstract]

2026 Mar 4;31(5):155. PMID: 41852897
Lasers Surg Med

Study on the Synergistic Mechanism of Photodynamic Therapy Combined With Ferroptosis Inducer to Induce Ferroptosis in Cholangiocarcinoma. [Abstract]

2024 Dec;56(10):845-853. PMID: 39468974
Oncol Lett

Identification of TFR2 as a novel ferroptosis‑related gene that serves an important role in prognosis and progression of triple‑negative breast cancer. [Abstract]

2023 Dec 5;27(2):43. PMID: 38106522
Neuroreport

Inhibition of inflammatory factor TNF-α by ferrostatin-1 in microglia regulates necroptosis of oligodendrocyte precursor cells. [Abstract]

2023 Aug 24;34(11):583-591. PMID: 37384932
Oncol Lett

Norcantharidin induces ferroptosis via the suppression of NRF2/HO-1 signaling in ovarian cancer cells. [Abstract]

2022 Aug 25;24(4):359. PMID: 36168316
Oncol Lett

Carboxymethylated pachyman induces ferroptosis in ovarian cancer by suppressing NRF1/HO-1 signaling. [Abstract]

2022 May;23(5):161. PMID: 35399331
Oncol Lett

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway. [Abstract]

2022 Mar;23(3):104. PMID: 35154435
Transl Cancer Res

TAF1 inhibitor Bay-299 induces cell death in acute myeloid leukemia. [Abstract]

2021 Dec;10(12):5307-5318. PMID: 35116379
Nephrology (Carlton)

2026 Jul;31(7):e70246. PMID: 42464422
Exp Anim

Diacerein alleviates endometrial fibrosis in an intrauterine adhesion model via ferroptosis inhibition. [Abstract]

2026 May 2. PMID: 42091527
Curr Med Sci

UXS1 Knockdown Suppresses Cell Proliferation and Invasion in Hepatocellular Carcinoma by Inducing Ferroptosis via SLC7A11/GPX4 Pathway. [Abstract]

2026 Apr;46(2):472-482. PMID: 41843361
Curr Med Sci

Huaier Aqueous Extract Combined with Gefitinib Promotes ACSL4-Dependent Ferroptosis and Overcomes Gefitinib Resistance in Non-Small Cell Lung Cancer. [Abstract]

2026 Feb;46(1):197-211. PMID: 41557244
Hematology

ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression. [Abstract]

2025 Dec;30(1):2451446. PMID: 39803678
In Vitro Cell Dev Biol Anim

Icariside II inhibits ferroptosis and improves high-glucose-induced podocytes injury by downregulating DNMT1. [Abstract]

2025 Dec 22. PMID: 41428160
Hematology

Shikonin promotes ferroptosis though NSUN2-mediated m5C methylation modification of TFRC in acute myelocytic leukemia. [Abstract]

2025 Dec;30(1):2495221. PMID: 40270446
Genes Genomics

Inhibition of MID1IP1 induces ferroptosis and suppresses c-Myc expression in colorectal cancer cell. [Abstract]

2025 Dec 4. PMID: 41343117
Genes Genomics

OTOP3 functions as an oncogenic regulator of ferroptosis-mediated colorectal cancer progression. [Abstract]

2025 Aug;47(8):911-922. PMID: 40586985
Hematology

Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. [Abstract]

2022 Dec;27(1):11-22. PMID: 34957935
Connect Tissue Res

Overexpression of NSUN3 suppresses ferroptosis in osteoarthritis chondrocytes by reducing m5C modification and expression of PCBP1 mRNA. [Abstract]

2026 May 8:1-12. PMID: 42101179
Neurol Res

AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway. [Abstract]

2025 Nov 10:1-17. PMID: 41215590
Neurol Res

TPEN attenuates neuronal ferroptosis in ischemic brain injury via GPR39-mediated PI3K/AKT signaling activation. [Abstract]

2025 Oct 21:1-14. PMID: 41117931
Exp Lung Res

PM2.5 induces ferroptosis in chronic obstructive pulmonary diseases via the GSK-3β/NRF2 pathway. [Abstract]

2025;51(1):79-92. PMID: 40889519
Am J Transl Res

TRIM62 promotes osteoarthritis progression by facilitating GPX4 ubiquitination and chondrocyte ferroptosis. [Abstract]

2026 May 15;18(5):4474-4491. PMID: 42325784
J Int Med Res

Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis. [Abstract]

2025 Nov;53(11):3000605251396755. PMID: 41299196
Pediatr Surg Int

Ferrostatin-1 protects against necrotizing enterocolitis intestinal injury by inhibiting ferroptosis. [Abstract]

2025 Nov 26;42(1):26. PMID: 41296081
Biocell

2025 Sep 25;49(9):1711-1731.
In Vivo

Mitochondrial Damage-induced Ferroptosis: The Molecular Mechanism by Which Psoralen Inhibits the Proliferation and Invasion of Non-small-cell Lung Cancer Cells. [Abstract]

2025 Sep-Oct;39(5):2681-2702. PMID: 40877163
Rejuvenation Res

Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage. [Abstract]

2023 Jun 6. PMID: 37279293
J Toxicol Sci

The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells. [Abstract]

2023;48(5):299-310. PMID: 37121744
Am J Transl Res

Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway. [Abstract]

2021 Jun 15;13(6):6031-6042. PMID: 34306342
Int Ophthalmol

Protective effects of luteolin on high glucose-induced ferroptosis in müller cells. [Abstract]

2025 Nov 19;45(1):494. PMID: 41258543
J Obstet Gynaecol Res

SOX4 inhibits ferroptosis and promotes proliferation of endometrial cancer cells via the p53/SLC7A11 signaling. [Abstract]

2024 Nov;50(11):2093-2106. PMID: 39318043
Curr Eye Res

HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production. [Abstract]

2023 Jan;48(1):25-33. PMID: 36300537
Acta Odontol Scand

PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis. [Abstract]

2022 Oct;80(7):535-546. PMID: 35723029
Lett Drug Des Discov

2026 Jun 22.
J Cardiothorac Surg

Inhibition of iron overload and ferroptosis attenuates sepsis-induced myocardial injury in mice through STAT3/Lcn2 pathway. [Abstract]

2026 Apr 15;21(1):284. PMID: 41987307
Microbiol Immunol

Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages. [Abstract]

2025 Aug;69(8):418-428. PMID: 40468416
Xenobiotica

α-Hederin inhibits osteosarcoma progression by triggering ferroptosis and disrupting mitochondrial function via PI3K/AKT signalling. [Abstract]

2025 Dec 4:1-15. PMID: 41342440
Tohoku J Exp Med

Curdione Suppresses Non-Small Cell Lung Cancer Growth by Inducing Ferroptosis. [Abstract]

2025 Nov 13. PMID: 41224330
Tohoku J Exp Med

Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulation and Hepatocellular Carcinoma Progression. [Abstract]

2025 Sep 25. PMID: 40993092
Crit Rev Eukaryot Gene Expr

METTL3 Promotes Mitochondrial Dysfunction and Neuronal Ferroptosis in Cerebral Ischemia and Reperfusion Injury through YTHDC1/SLC7A11 Modification. [Abstract]

2025 Jun 24;35(6):59-70. PMID: 40972099
Nat Prod Commun

2023 Aug 16.
Biosci Biotechnol Biochem

Resveratrol pretreatment protects neurons from oxygen-glucose deprivation/reoxygenation and ischemic injury through inhibiting ferroptosis. [Abstract]

2022 May 24;86(6):704-716. PMID: 35357412
Nat Prod Commun

2020 Dec 22.
Mol Cell Toxicol

2022.
Eur J Integr Med

2026 Jul 9;87:102716.
Andrologia

2023 Nov 15.
Tradit Med Res

2023 Sep 18;8(12):67.
bioRxiv

2026 Jul 23.
bioRxiv

2026 Jul 21:2026.07.15.738733. PMID: 42538948
Zoonoses

2026 Jun 5.
University of Puerto Rico

2026.
Res Sq

2026 Jun 12.
Northwestern University

2026.
bioRxiv

Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence. [Abstract]

2026 Jun 1:2026.05.29.728786. PMID: 42282648
bioRxiv

2026 Jun 30:2026.06.29.733391. PMID: 42427686
Res Sq

2026 May 27.
SSRN

2026 May 15.
bioRxiv

2026 May 20.
bioRxiv

Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]

2026 Apr 1:2026.03.31.715684. PMID: 41959015
SSRN

2026 Mar 20.
Res Sq

2026 Mar 10.
bioRxiv

2026 Mar 16.
SSRN

2026 Mar 4.
Preprints

2026 Feb 10.
SSRN

2026 Feb 3.
J Environ Sci (China)

Oxidative stress and iron homeostasis imbalance mediate AlCl3-induced liver damage in mice. [Abstract]

2026 Feb:160:581-590. PMID: 41177639
bioRxiv

2026 Feb 2.
Res Sq

2026 Jan 9.
SSRN

2026 Jan 2.
Res Sq

2026 Jan 12.
bioRxiv

2026 Jan 26.
Res Sq

2026 Jan 15.
Thomas Jefferson University

2025.
Res Sq

2025 Dec 3.
SSRN

2025 Nov 16.
Res Sq

2025 Oct 28.
Res Sq

2025 Oct 6.
SSRN

2025 Sep 12.
Authorea

2025 Sep 13.
SSRN

2025 Sep 23.
SSRN

2025 Sep 17.
Res Sq

2025 Sep 9.
University of Pennsylvania

2025.
Res Sq

2025 Aug 08.
University of Chicago

2025 Aug.
Res Sq

2025 Jul 29.
SSRN

2025 Jun 6.
SSRN

2025 May 27.
Res Sq

2025 May 22.
Cell Investig

2025 May 31.
Res Sq

2025 Apr 20.
SSRN

2025 Apr 4.
bioRxiv

2025 April 09.
SSRN

2025 Jan 24.
SSRN

2025 Mar 20.
SSRN

2025 Feb 21.
SSRN

2025 Mar 20.
SSRN

2025 Jan 08.
DNA (Basel)

2025 Mar 12.
bioRxiv

2025 January 22.
SSRN

2025 Jan 24.
Res Sq

2025 Feb 16.
University of Zurich

2025 Feb 03.
Research Square Preprint

2024 Oct 13.
Sci Total Environ

Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis. [Abstract]

2025 Jan 10:959:178167. PMID: 39721551
Authorea

2025 Jan 18.
Res Sq

2024 Sep 16.
bioRxiv

2024 September 26.
Res Sq

2024 Sep 02.
Res Sq

2024 Sep 08.
Res Sq

2024 Oct 27.
bioRxiv

2024 October 21.
Biomed Pharmacother

Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway. [Abstract]

2024 Nov:180:117529. PMID: 39393329
Sci Total Environ

2,2',4,4'-Tetrabromodiphenyl ether exposure disrupts blood-testis barrier integrity through CMA-mediated ferroptosis. [Abstract]

2024 Oct 20:948:174738. PMID: 39009145
Biomed Pharmacother

Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation. [Abstract]

2024 Oct:179:117309. PMID: 39151312
Chemosphere

Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro. [Abstract]

2024 Sep:364:143004. PMID: 39097112
Heliyon

Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer. [Abstract]

2024 Sep 17;10(18):e38021. PMID: 39347400
Heliyon

Cigarette smoke extract induces ferroptosis in human retinal pigment epithelial cells. [Abstract]

2024 Sep 24;10(20):e38151. PMID: 39498038
Res Sq

2024 May 20.
bioRxiv

2024 Aug 6.
Res Sq

2024 Jul 09.
Environ Toxicol

Functional mechanism of hypoxia-like conditions mediating resistance to ferroptosis in cervical cancer cells by regulating KDM4A SUMOylation and the SLC7A11/GPX4 pathway. [Abstract]

2024 Aug;39(8):4207-4220. PMID: 38727079
Biomed Pharmacother

Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy. [Abstract]

2024 Aug:177:116918. PMID: 38878639
Sci Total Environ

Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction. [Abstract]

2024 Aug 25:940:173575. PMID: 38823712
SSRN

2024 Jul 16.
Res Sq

2024 Jul 15.
Biomed Pharmacother

Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway. [Abstract]

2024 Jul:176:116866. PMID: 38876045
SSRN

2024 Jun 18.
Heliyon

AP-1 inhibitor induces ferroptosis via the PI3K/AKT pathway in multiple myeloma cells. [Abstract]

2024 Jul 10;10(14):e34397. PMID: 39104494
Environ Toxicol

High expression of AlkB homolog 5 suppresses the progression of non-small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11. [Abstract]

2024 Jul;39(7):4035-4046. PMID: 38642004
Sci Total Environ

GPX4 degradation contributes to fluoride-induced neuronal ferroptosis and cognitive impairment via mtROS-chaperone-mediated autophagy. [Abstract]

2024 Jun 1:927:172069. PMID: 38582117
Heliyon

Induction of ferroptosis by brucine suppresses gastric cancer progression through the p53-mediated SLCA711/ALOX12 axis. [Abstract]

2024 Jun 26;10(13):e33674. PMID: 39050447
Res Sq

2024 May 8.
Res Sq

2024 May 20.
Research Square Preprint

2024 May 7.
Sci Total Environ

Cr(VI) induces ferroptosis in DF-1 cells by simultaneously perturbing iron homeostasis of ferritinophagy and mitophagy. [Abstract]

2024 May 15:925:171818. PMID: 38508245
Heliyon

2024 Apr 26.
Aging (Albany NY)

Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis. [Abstract]

2024 Apr 19;16(8):7277-7292. PMID: 38643467
Biomed Pharmacother

Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η. [Abstract]

2024 May:174:116542. PMID: 38574620
Heliyon

Naringenin alleviates liver ﬁbrosis by triggering autophagy-dependent ferroptosis in hepatic stellate cells. [Abstract]

2024 Mar 29;10(7):e28865. PMID: 38576562
Heliyon

Artesunate induces ferroptosis by regulating MT1G and has an additive effect with doxorubicin in diffuse large B-cell lymphoma cells. [Abstract]

2024 Mar 22;10(7):e28584. PMID: 38560249
SSRN

2024 Mar 8.
Heliyon

Plumbagin induces ferroptosis in colon cancer cells by regulating p53-related SLC7A11 expression. [Abstract]

2024 Mar 21;10(7):e28364. PMID: 38596137
Sci Total Environ

PM2.5 exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway. [Abstract]

2024 Feb 1:910:168578. PMID: 37981141
medRxiv

2024 Feb 8.
Research Square Preprint

2024 Feb 20.
Research Square Preprint

2024 Feb 2.
Sci Total Environ

Ferroptosis participated in inhaled polystyrene nanoplastics-induced liver injury and fibrosis. [Abstract]

2024 Mar 15:916:170342. PMID: 38278228
Heliyon

YAP promotes the healing of ischemic wounds by reducing ferroptosis in skin fibroblasts through inhibition of ferritinophagy. [Abstract]

2024 Jan 16;10(2):e24602. PMID: 38298641
bioRxiv

2023 Dec 20.
Research Square Preprint

2023 Dec 12.
SSRN

2023 Dec 11.
Research Square Preprint

2023 Nov 17.
SSRN

2023 Nov 8.
Research Square Preprint

2023 Oct 23.
Research Square Preprint

2023 Oct 13.
Chemosphere

Low-dose antimony exposure promotes prostate cancer proliferation by inhibiting ferroptosis via activation of the Nrf2-SLC7A11-GPX4 pathway. [Abstract]

2023 Oct:339:139716. PMID: 37562508
Research Square Preprint

2023 Sep 15.
Research Square Preprint

2023 Sep 6.
Research Square Preprint

2023 Sep 18.
Biomed Pharmacother

Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity. [Abstract]

2023 Sep:165:115248. PMID: 37523980
Biomed Pharmacother

Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis. [Abstract]

2023 Sep:165:115185. PMID: 37487441
Sci Total Environ

Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers. [Abstract]

2023 Sep 10:890:164172. PMID: 37201840
Research Square Preprint

2023 Aug 31.
Phytomed Plus

2023 Aug 25, 100482.
Biomed Pharmacother

Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis. [Abstract]

2023 Aug:164:114986. PMID: 37295251
SSRN

2023 Jun 27.
bioRxiv

2023 May 9.
SSRN

2023 May 22.
Res Sq

2023 Apr 19.
bioRxiv

2023 Apr 17.
SSRN

2023 Mar 20.
Research Square Print

2023 Mar 16.
bioRxiv

2023 Feb 8.
Evid Based Complement Alternat Med

δ-Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP-Induced Parkinson Disease Models. [Abstract]

2023 Feb 10:2023:4130937. PMID: 36818224
Oxid Med Cell Longev

Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer. [Abstract]

2023 Jan 31:2023:1367938. PMID: 36760347
Biomed Pharmacother

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways. [Abstract]

2023 Jan:157:114048. PMID: 36463827
Research Square Print

November 29th, 2022.
Oxid Med Cell Longev

Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1 α Axis. [Abstract]

2022 Nov 18:2022:7862430. PMID: 36439690
Oxid Med Cell Longev

Theaflavin-3,3'-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts. [Abstract]

2022 Oct 25:2022:8966368. PMID: 36329803
Oxid Med Cell Longev

Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. [Abstract]

2022 Oct 4:2022:2353115. PMID: 36246395
Research Square Print

October 14th, 2022.
Heliyon

3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway. [Abstract]

2022 Oct 12;8(10):e11013. PMID: 36276736
Pharmacological Research-Modern Chinese Medicine

29 August 2022, 100157.
Environ Toxicol

PM2 .5 exposure-induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway. [Abstract]

2022 Sep;37(9):2201-2213. PMID: 35608139
Research Square Print

September 1st, 2022.
Oxid Med Cell Longev

Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway. [Abstract]

2022 Aug 4:2022:9325973. PMID: 35965682
Research Square Print

2022 Aug.
Oxid Med Cell Longev

lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p/ACSL4 Axis in Diabetic Retinopathy. [Abstract]

2022 Aug 31;2022:9004738. PMID: 36092160
Research Square Print

August 18th, 2022.
Oxid Med Cell Longev

Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration. [Abstract]

2022 Jul 5:2022:8983667. PMID: 35847582
Oxid Med Cell Longev

Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage. [Abstract]

2022 Jul 9:2022:9069825. PMID: 35855863
Research Square Print

2022 Jul.
Research Square Preprint

2022 Jul.
Oxid Med Cell Longev

miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2. [Abstract]

2022 Jun 9;2022:6520789. PMID: 35720183
Oxid Med Cell Longev

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway. [Abstract]

2022 Jun 13:2022:8091464. PMID: 35733794
Biomed Pharmacother

Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis-mediated glutathione oxidation-reduction system. [Abstract]

2022 Jun;150:112927. PMID: 35398749
Oxid Med Cell Longev

Ferroptosis Induction Improves the Sensitivity of Docetaxel in Prostate Cancer. [Abstract]

2022 May 24:2022:4930643. PMID: 39282153
Oxid Med Cell Longev

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease. [Abstract]

2022 May 5;2022:5463134. PMID: 35571244
Research Square Preprint

2022 May.
Comput Intell Neurosci

MiR-375-3p Promotes Cardiac Fibrosis by Regulating the Ferroptosis Mediated by GPX4. [Abstract]

2022 Apr 22;2022:9629158. PMID: 35498204
Oxid Med Cell Longev

HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation. [Abstract]

2022 Apr 25;2022:3846217. PMID: 35656025
Oxid Med Cell Longev

High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis. [Abstract]

2022 Apr 18;2022:9304383. PMID: 35480874
Bioengineered

Ferrostatin-1 alleviates cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis. [Abstract]

2022 Mar;13(3):6163-6172. PMID: 35200065
Oxid Med Cell Longev

Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice. [Abstract]

2022 Feb 27:2022:1193734. PMID: 35265258
Environ Toxicol

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. [Abstract]

2022 Feb;37(2):192-200. PMID: 34661962
Oxid Med Cell Longev

MPO/HOCl Facilitates Apoptosis and Ferroptosis in the SOD1G93A Motor Neuron of Amyotrophic Lateral Sclerosis. [Abstract]

2022 Feb 7;2022:8217663. PMID: 35178161
Dis Markers

Ferroptosis-Specific Inhibitor Ferrostatin-1 Relieves H2O2-Induced Redox Imbalance in Primary Cardiomyocytes through the Nrf2/ARE Pathway. [Abstract]

2022 Feb 22:2022:4539932. PMID: 35242242
Research Square Preprint

2022 Jan.
Bioengineered

ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy. [Abstract]

2021 Dec;12(2):11610-11621. PMID: 34666603
Research Square Preprint

2021 Dec.
Research Square Preprint

2021 Dec.
Research Square Preprint

2021 Nov.
Research Square Preprint

2021 Nov.
Research Square Preprint

2021 Nov.
Research Square Preprint

2021 Oct.
Research Square Preprint

2021 Jul.
Environ Toxicol

Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes. [Abstract]

2021 Apr;36(4):520-529. PMID: 33166055
Oxid Med Cell Longev

Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance. [Abstract]

2021 Apr 1:2021:6629804. PMID: 33868572
Nanoscale Res Lett

Fe(II) and Tannic Acid-Cloaked MOF as Carrier of Artemisinin for Supply of Ferrous Ions to Enhance Treatment of Triple-Negative Breast Cancer. [Abstract]

2021 Feb 23;16(1):37. PMID: 33620584
Oxid Med Cell Longev

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo. [Abstract]

2021 Feb 10:2021:6670497. PMID: 33628376
Environ Toxicol

Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis. [Abstract]

2021 Feb;36(2):257-266. PMID: 32951314
bioRxiv

2020 Dec 14.
Research Square Preprint

2020 Oct.
J Oncol

Inhibition of JK184-Induced Cytoprotective Autophagy Potentiates JK184 Antitumor Effects in Breast Cancer. [Abstract]

2020 Jun 2:2020:1657896. PMID: 32565796
Eur Rev Med Pharmacol Sci

Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. [Abstract]

2020 Mar;24(5):2585-2600. PMID: 32196629
Aging (Albany NY)

Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage. [Abstract]

2020 Feb 18;12(4):3662-3681. PMID: 32074079
bioRxiv

2019 Oct 28.
bioRxiv

2019 Oct.

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (476.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.8117 mL

19.0585 mL

38.1170 mL

5 mM

0.7623 mL

3.8117 mL

7.6234 mL

10 mM

0.3812 mL

1.9059 mL

3.8117 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (7.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 90% Saline

Solubility: 0.2 mg/mL (0.76 mM); Clear solution; Need ultrasonic

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 5 mg/mL (19.06 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (287 KB)
SDS (394 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072. [Content Brief]

[2]. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556. [Content Brief]

[3]. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078. [Content Brief]

[4]. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27. [Content Brief]

[5]. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.

[6]. Zhang M, et al. Ferrostatin-1 attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis. Transl Pediatr. 2023 Nov 28;12(11):1944-1970. [Content Brief]

[7]. Cheon YI, et al. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. Aging (Albany NY). 2023 Apr 6;15(7):2418-2432. [Content Brief]

[8]. Morrow J P, et al. Poly (2-oxazoline)-Ferrostatin-1 drug conjugates inhibit ferroptotic cell death[J]. Journal of Controlled Release, 2022, 350: 193-203. [Content Brief]

[9]. Xie Q, et al. Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis. Arch Biochem Biophys. 2023 Mar 1;736:109535. [Content Brief]

[10]. Chu J, et al. Ferrostatin-1 protects HT-22 cells from oxidative toxicity[J]. Neural regeneration research, 2020, 15(3): 528-536. [Content Brief]

[11]. Xie J, et al. Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. Mol Med Rep. 2022 Aug;26(2):256. [Content Brief]

[12]. Ling M, et al. Ferrostatin-1 alleviates ventilator-induced lung injury by inhibiting ferroptosis[J]. International Immunopharmacology, 2023, 120: 110356. [Content Brief]

[13]. Y Teng, et al. "Ferrostatin 1 ameliorates UVB‐induced damage of HaCaT cells by regulating ferroptosis." Experimental Dermatology 33.2 (2024): e15018. [Content Brief]

[14]. Li S, et al. Ferrostatin-1 alleviates angiotensin II (Ang II)-induced inflammation and ferroptosis in astrocytes[J]. International immunopharmacology, 2021, 90: 107179. [Content Brief]

[15]. Liu N, et al. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance[J]. British journal of cancer, 2020, 122(2): 279-292. [Content Brief]

[16]. Zhang Z, et al. CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes[J]. Nature Chemical Biology, 2024, 20(6): 699-709. [Content Brief]

[17]. Hanke N, et al. Inhibition of autophagy rescues HT22 hippocampal neurons from erastin-induced ferroptosis[J]. Neural regeneration research, 2023, 18(7): 1548-1552. [Content Brief]

[18]. Wang X, et al. Melatonin alleviates acute sleep deprivation-induced memory loss in mice by suppressing hippocampal ferroptosis[J]. Frontiers in pharmacology, 2021, 12: 708645. [Content Brief]

[19]. Du J, et al. Identification of Frataxin as a regulator of ferroptosis[J]. Redox biology, 2020, 32: 101483. [Content Brief]

[20]. Cheff D M, et al. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1[J]. Redox Biology, 2023, 62: 102703. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8117 mL	19.0585 mL	38.1170 mL	95.2925 mL
	5 mM	0.7623 mL	3.8117 mL	7.6234 mL	19.0585 mL
	10 mM	0.3812 mL	1.9059 mL	3.8117 mL	9.5293 mL
	15 mM	0.2541 mL	1.2706 mL	2.5411 mL	6.3528 mL
	20 mM	0.1906 mL	0.9529 mL	1.9059 mL	4.7646 mL
	25 mM	0.1525 mL	0.7623 mL	1.5247 mL	3.8117 mL
	30 mM	0.1271 mL	0.6353 mL	1.2706 mL	3.1764 mL
	40 mM	0.0953 mL	0.4765 mL	0.9529 mL	2.3823 mL
	50 mM	0.0762 mL	0.3812 mL	0.7623 mL	1.9059 mL
	60 mM	0.0635 mL	0.3176 mL	0.6353 mL	1.5882 mL
	80 mM	0.0476 mL	0.2382 mL	0.4765 mL	1.1912 mL
	100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9529 mL

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Ferrostatin-1

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Ferrostatin-1

Publications Citing Use of MedChemExpress (MCE) Ferrostatin-1