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JSH-23

159 Cited Publications
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Based on 159 publication(s) in Google Scholar

JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation.

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  • Pureza: 98.02%
  • No. CAS: 749886-87-1
  • Fòrmula: C16H20N2
  • Peso molecular:240.34
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • JSH-23 Chemical Structure
    JSH-23 Chemical Structure
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
  • Experimental Validation Results for JSH-23
No. CAS: 749886-87-1
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  • JSH-23 Chemical Structure
    JSH-23 Chemical Structure
    1/16
  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Apr 14;42(4):112403. [Abstract]

    Customer Validation
     JSH-23 (10 μM; 6 days) significantly inhibits nuclear translocation of NF-kB p65 in SSC cells.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: Front Bioeng Biotechnol. 2020 May 8:8:392. [Abstract]

    Customer Validation
     Acta2 expression after Signaling inhibitors by q-PCR. For inhibitor treatment, 24 h after seeding, the medium is removed and replaced with the NF-κB inhibitor JSH-23 (50 μM) to block the NF-κB signaling pathways.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 Aug 1:428:77-89. [Abstract]

    Customer Validation
     Western blots show that the NF-κB inhibitors BAY11-7082, Parthenolide, and JSH-23 cause dramatic time- and dose-dependent reductions in MGMT protein expression in LN18 and T98G glioma cells.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: J Mol Cell Biol. 2019 Jun 1;11(6):496-508. [Abstract]

    Customer Validation
     Cytoplasmic LPS-induced GSDMB and GSDMD expression are both significantly attenuated by either JSH-23 or QNZ.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 21:9:660. [Abstract]

    Customer Validation
     By Western blotting, the α-SMA and palladin proteins are determined in cells that are pretreated with NF-κB (JSH-23), Wnt/β-catenin (XAV939), EGFR (erlotinib), p38 MAPK (TAK-715), and Smad3 (SIS3) inhibitors and are followed by TWEAK stimulation.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2017;10(6):6544-6551.

    Customer Validation
     JSH-23 is added into MDA-MB-231 cells with the dose of 0 μmol, 1 μmol, 5 μmol when the cell planking density reaches about 60%. Then samples incubated for 24 h are collected when the cell density reaches about 80% and confirmed by western blot.

  • 1/16

    JSH-23 purchased from MedChemExpress. Usage Cited in: PLoS One. 2016 Nov 16;11(11):e0166740. [Abstract]

    Customer Validation
     HG-induced apoptosis in neonatal rat cardiomyocytes is mediated by activation of the NF-κB pathway. (A-B). Neonatal rat cardiomyocytes are pretreated with 10–20 μM JSH-23 and exposed to HG for 36 h. Levels of caspase-3 and cleaved caspase-3 and Bax/Bcl-2 ratios are determined by western blotting.

  • JSH-23