Jaceosidin
Based on 9 publication(s) in Google Scholar
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.51%
- No. CAS: 18085-97-7
- Fòrmula: C17H14O7
- Peso molecular:330.29
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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BAI1BAX Inhibitor -
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Jaceosidin (Standard) -
HY-10087
NavitoclaxBcl-2 Inhibitor -
HY-15531
VenetoclaxBCL-2 Inhibitor -
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ABT-737Bcl-2 Family Inhibitor/BH3 Mimetic -
HY-100741
S63845MCL1 Inhibitor -
HY-114855
BT2BCKDC Kinase Inhibitor -
HY-103243
TCPOBOPCAR Agonist
Publications Citing Use of MedChemExpress (MCE) Jaceosidin
More- Acta Pharm Sin B. 2021 Jan;11(1):143-155. [Abstract]
- Phytomedicine. 2026 Jun 17:159:158446. [Abstract]
- Phytomedicine. 2026 Mar:152:157826. [Abstract]
- Food Chem. 2025 Dec 30:497:146992. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Cell Mol Neurobiol. 2022 Jul;42(5):1487-1500. [Abstract]
- Ind Crops Prod. 2025 Dec 11;239:122458.
- Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
- Ultrastruct Pathol. 2023 Sep 3;47(5):388-397. [Abstract]
Customer Validation & Images
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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Flow Cytometry
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IF
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WB
Actividad biológica
Descripciòn
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Bax |
COX-2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| BV-2 | IC50 |
27 μM
Compound: 43
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Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production by Griess reagent based analysis
Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production by Griess reagent based analysis
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[PMID: 37683361] |
| HEK-293T | IC50 |
11.3 μM
Compound: 34
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Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit
Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit
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[PMID: 21650152] |
| T-cell | IC50 |
5.8 μM
Compound: 12
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Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
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[PMID: 31181920] |
| THP-1 | IC50 |
70.54 μM
Compound: Jaceosidin
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Cytotoxicity against human THP1 cells after 48 hrs by trypan blue dye exclusion counting method
Cytotoxicity against human THP1 cells after 48 hrs by trypan blue dye exclusion counting method
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[PMID: 31784199] |
In Vitro
Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells[1].
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Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation[1].
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Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity[1].
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Jaceosidin shows cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM, respectively), after treatment for 48 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hec1A, KLE, HES and HESC cells
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Concentration:3.125, 6.25, 12.5, 25, 50, and 100 μM
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Incubation Time:48 hour
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Result:Showed cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM).
In Vivo
? Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3].
? Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-week-old male BALB/c mice (23-26 g)[3]
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Dosage:10 and 20 mg/kg
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Administration:P.O. once a day for 3 days
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Result:Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.
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Animal Model:Male Sprague-Dawley rats (180-200 g)[3]
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Dosage:20 mg/kg
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Administration:P.O., for 2 hour
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Result:Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.
Chemical Information
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No. CAS 18085-97-7
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Appearance Solid
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Peso molecular 330.29
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Fòrmula C17H14O7
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Color Light yellow to yellow
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SMILES
O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]2021 Jan;11(1):143-155. PMID: 33532186 -
Phytomedicine
Therapeutic effects of jaceosidin on atopic dermatitis via ubiquitin-mediated JAK1 degradation. [Abstract]2026 Jun 17:159:158446. PMID: 42341525 -
Phytomedicine
From virtual screening to functional discovery: Apigenin ameliorates acute pancreatitis by targeting HINT2 to regulate the mitochondrial acetylome. [Abstract]2026 Mar:152:157826. PMID: 41579589 -
Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Cell Mol Neurobiol
MircoRNA-29a in Astrocyte-derived Extracellular Vesicles Suppresses Brain Ischemia Reperfusion Injury via TP53INP1 and the NF-κB/NLRP3 Axis. [Abstract]2022 Jul;42(5):1487-1500. PMID: 33620674 -
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Toxicol Appl Pharmacol
Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1. [Abstract]2025 Jun:499:117327. PMID: 40187661
Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
Colony formation assay of PC9-OR cells treated with Osimertinib, Jaceosidin or combined Osimertinib and Jaceosidin.
Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
Effect of Jaceosidin in LCO-OR cells on Osimertinib 72 h.
Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
Cell cycle distribution was analyzed by flow cytometry after 72 h of treatment with 4 μM Osimertinib, 60 μM Jaceosidin, or a combination of both.
Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
Immunofluorescence staining showed cdc2/Cyclin B1 expression after treating with Osimertinib, Jaceosidin (60 μM), or a combination in PC9-OR cells.
Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Jun:499:117327. [Abstract]
Western blot analysis G2/M phase-related protein expressions after treating Osimertinib, Jaceosidin (60 μM), alone or a combination.
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Ultrastruct Pathol
The effects of cisplatin and jaceosidin on SH-SY5Y neuroblastoma cells: an electron microscopic, molecular and biochemical study. [Abstract]2023 Sep 3;47(5):388-397. PMID: 37246956
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (378.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Woo SM, et al. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chem Biol Interact. 2016 Dec 25;260:168-175. [Content Brief]
[2]. Lee JG, et al. Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem Toxicol. 2013 May;55:214-21. [Content Brief]
[3]. Min SW, et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J Ethnopharmacol. 2009 Sep 25;125(3):497-500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0276 mL | 15.1382 mL | 30.2764 mL | 75.6911 mL |
| 5 mM | 0.6055 mL | 3.0276 mL | 6.0553 mL | 15.1382 mL | |
| 10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL | 7.5691 mL | |
| 15 mM | 0.2018 mL | 1.0092 mL | 2.0184 mL | 5.0461 mL | |
| 20 mM | 0.1514 mL | 0.7569 mL | 1.5138 mL | 3.7846 mL | |
| 25 mM | 0.1211 mL | 0.6055 mL | 1.2111 mL | 3.0276 mL | |
| 30 mM | 0.1009 mL | 0.5046 mL | 1.0092 mL | 2.5230 mL | |
| 40 mM | 0.0757 mL | 0.3785 mL | 0.7569 mL | 1.8923 mL | |
| 50 mM | 0.0606 mL | 0.3028 mL | 0.6055 mL | 1.5138 mL | |
| 60 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2615 mL | |
| 80 mM | 0.0378 mL | 0.1892 mL | 0.3785 mL | 0.9461 mL | |
| 100 mM | 0.0303 mL | 0.1514 mL | 0.3028 mL | 0.7569 mL |
Jaceosidin Related Classifications
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