Novaluron
Based on 1 Customer Validation
Novaluron is a chemical with insecticide properties, an insect growth regulator, and has adverse effects on mouse sperm.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.78%
- No. CAS: 116714-46-6
- Fòrmula: C17H9ClF8N2O4
- Peso molecular:492.70
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Novaluron (0-100 μM, 90 min) inhibits the viability of mouse spermatocytes[1].
Novaluron (10-100 µM, 90 min) significantly reduces the number of acrosome-reactive sperm, significantly reduces sperm motility, and changes PKA activity and tyrosine phosphorylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Sperm cells
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Concentration:0, 0.1, 1, 10, 100 μM
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Incubation Time:90 min
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Result:Inhibited cell viability.
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Cell Line:Sperm cells
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Concentration:0, 0.1, 1, 10, 100 μM
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Incubation Time:90 min
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Result:Altered in PKA activity and tyrosine phosphorylation.
Chemical Information
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No. CAS 116714-46-6
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Appearance Solid
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Peso molecular 492.70
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Fòrmula C17H9ClF8N2O4
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Color White to gray
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SMILES
O=C(NC(NC1=CC=C(OC(F)(F)C(F)OC(F)(F)F)C(Cl)=C1)=O)C2=C(F)C=CC=C2F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 120 mg/mL (243.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 3 mg/mL (6.09 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (459 KB)
- English - EN (459 KB)
- Français - FR (459 KB)
- Deutsch - DE (459 KB)
- Norwegian - NO (459 KB)
- Español - ES (459 KB)
- Swedish - SV (459 KB)
- Italian - IT (459 KB)
- Korean - KR (459 KB)
- Portuguese - PT (459 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0296 mL | 10.1482 mL | 20.2963 mL | 50.7408 mL |
| 5 mM | 0.4059 mL | 2.0296 mL | 4.0593 mL | 10.1482 mL | |
| 10 mM | 0.2030 mL | 1.0148 mL | 2.0296 mL | 5.0741 mL | |
| 15 mM | 0.1353 mL | 0.6765 mL | 1.3531 mL | 3.3827 mL | |
| 20 mM | 0.1015 mL | 0.5074 mL | 1.0148 mL | 2.5370 mL | |
| 25 mM | 0.0812 mL | 0.4059 mL | 0.8119 mL | 2.0296 mL | |
| 30 mM | 0.0677 mL | 0.3383 mL | 0.6765 mL | 1.6914 mL | |
| 40 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2685 mL | |
| 50 mM | 0.0406 mL | 0.2030 mL | 0.4059 mL | 1.0148 mL | |
| 60 mM | 0.0338 mL | 0.1691 mL | 0.3383 mL | 0.8457 mL | |
| 80 mM | 0.0254 mL | 0.1269 mL | 0.2537 mL | 0.6343 mL | |
| 100 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5074 mL |
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