RI-2
Based on 1 publication(s) in Google Scholar
RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.90%
- No. CAS: 1417162-36-7
- Fòrmula: C21H18Cl2N2O4
- Peso molecular:433.28
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) RI-2
More
Actividad biológica
Descripciòn
IC50 & Target
IC50: 44.17 μM (RAD51)[1]
In Vitro
RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1417162-36-7
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Appearance Solid
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Peso molecular 433.28
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Fòrmula C21H18Cl2N2O4
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Color Yellow to orange
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SMILES
O=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
In Vitro:
DMSO : 130 mg/mL (300.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3080 mL | 11.5399 mL | 23.0798 mL | 57.6994 mL |
| 5 mM | 0.4616 mL | 2.3080 mL | 4.6160 mL | 11.5399 mL | |
| 10 mM | 0.2308 mL | 1.1540 mL | 2.3080 mL | 5.7699 mL | |
| 15 mM | 0.1539 mL | 0.7693 mL | 1.5387 mL | 3.8466 mL | |
| 20 mM | 0.1154 mL | 0.5770 mL | 1.1540 mL | 2.8850 mL | |
| 25 mM | 0.0923 mL | 0.4616 mL | 0.9232 mL | 2.3080 mL | |
| 30 mM | 0.0769 mL | 0.3847 mL | 0.7693 mL | 1.9233 mL | |
| 40 mM | 0.0577 mL | 0.2885 mL | 0.5770 mL | 1.4425 mL | |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4616 mL | 1.1540 mL | |
| 60 mM | 0.0385 mL | 0.1923 mL | 0.3847 mL | 0.9617 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2885 mL | 0.7212 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5770 mL |
RI-2 Related Classifications
HY-16904 Related Classifications
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