Sabinene
Based on 2 publication(s) in Google Scholar
Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways.
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- Pureza: 79.94%
- No. CAS: 3387-41-5
- Fòrmula: C10H16
- Peso molecular:136.24
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Sabinene
More
Actividad biológica
Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IL-6 myoblasts
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Concentration:300 μM
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Incubation Time:18 and 48 hours
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Result:Failed to affect the viability of IL-6 myoblasts after 48 h incubation and recovered more than 50% of starvation-induced myoblast atrophy after 18 h.
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Cell Line:IL-6 myoblasts
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Concentration:300 μM
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Incubation Time:18 hours
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Result:Attenuated muscle atrophy-related signaling proteins phosphorylation in starved myotubes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fasted animal model in rat[2]
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Dosage:6.4 mg/kg
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Administration:Oral gavage; once daily; during the fasting for 2 days
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Result:Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats.
Chemical Information
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No. CAS 3387-41-5
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Appearance Liquid (Density: 0.842 g/cm3)
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Peso molecular 136.24
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Fòrmula C10H16
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Color Colorless to light yellow
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SMILES
CC(C12CCC(C1C2)=C)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Solvente y solubilidad
DMSO : 100 mg/mL (734.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (605 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Cao Y, et al. Biosynthesis and production of sabinene: current state and perspectives. Appl Microbiol Biotechnol. 2018 Feb;102(4):1535-1544. [Content Brief]
[2]. Ryu Y, et al. Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK-MuRF-1 Pathway in Rats. Int J Mol Sci. 2019 Oct 8;20(19):4955. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.3400 mL | 36.6999 mL | 73.3999 mL | 183.4997 mL |
| 5 mM | 1.4680 mL | 7.3400 mL | 14.6800 mL | 36.6999 mL | |
| 10 mM | 0.7340 mL | 3.6700 mL | 7.3400 mL | 18.3500 mL | |
| 15 mM | 0.4893 mL | 2.4467 mL | 4.8933 mL | 12.2333 mL | |
| 20 mM | 0.3670 mL | 1.8350 mL | 3.6700 mL | 9.1750 mL | |
| 25 mM | 0.2936 mL | 1.4680 mL | 2.9360 mL | 7.3400 mL | |
| 30 mM | 0.2447 mL | 1.2233 mL | 2.4467 mL | 6.1167 mL | |
| 40 mM | 0.1835 mL | 0.9175 mL | 1.8350 mL | 4.5875 mL | |
| 50 mM | 0.1468 mL | 0.7340 mL | 1.4680 mL | 3.6700 mL | |
| 60 mM | 0.1223 mL | 0.6117 mL | 1.2233 mL | 3.0583 mL | |
| 80 mM | 0.0917 mL | 0.4587 mL | 0.9175 mL | 2.2937 mL | |
| 100 mM | 0.0734 mL | 0.3670 mL | 0.7340 mL | 1.8350 mL |
Sabinene Related Classifications
HY-108943 Related Classifications
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