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Referencia número: HY-P11941

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Acein-1

Acein-1 is an angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 16 μM against rabbit lung ACE. Acein-1 does not bind to the catalytic site of ACE and cannot be hydrolyzed by ACE. Acein-1 can be used in the research of hypertension.

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No. CAS: 180341-69-9
Fòrmula: C₄₄H₆₆N₁₀O₁₂
Peso molecular:927.05

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acein-1 Chemical Structure

No. CAS: 180341-69-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

No. CAS 180341-69-9
Peso molecular 927.05
Fòrmula C₄₄H₆₆N₁₀O₁₂
SMILES

OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(C)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O
Sequence

Tyr-Leu-Tyr-Glu-Ile-Ala-Arg
Sequence Shortening

YLYEIAR
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nakagomi K, et al. Acein-1, a novel angiotensin-I-converting enzyme inhibitory peptide isolated from tryptic hydrolysate of human plasma. FEBS letters. 1998 Nov 06;438(3):255-7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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