Alexidine
Based on 5 publication(s) in Google Scholar
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
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- No. CAS: 22573-93-9
- Fòrmula: C26H56N10
- Peso molecular:508.79
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Publications Citing Use of MedChemExpress (MCE) Alexidine
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Actividad biológica
Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C. albicans, C. auris, A. fumigatus
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Concentration:10 µM
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Incubation Time:24 hours
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Result:Could significantly kill 80% of mature biofilm community.
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Cell Line:HUVECs, lung A549 cells
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Concentration:0-60 μg/ml
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Incubation Time:24 hours
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Result:resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old C57BL/6 male mice
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Dosage:3 µg/ml
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Administration:Jugular vein-catheterized, 48 hours, 3 µg/ml, once
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Result:Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
Chemical Information
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No. CAS 22573-93-9
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Peso molecular 508.79
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Fòrmula C26H56N10
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SMILES
N=C(NCC(CC)CCCC)NC(NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N)=N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]2025 Apr 6;16(1):257. PMID: 40189563 -
Free Radic Biol Med
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation. [Abstract]2025 Jun 14:237:585-599. PMID: 40518125 -
Cell Rep
A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]2025 Nov 25;44(11):116496. PMID: 41166305 -
Biochem Biophys Res Commun
2026 Jan 18:796:153158. PMID: 41418346 -
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alexidine Related Classifications
HY-B1474 Related Classifications
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