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Referencia número: HY-148269

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AN13762

AN13762 is a benzoxaborole antimalarial agent. AN13762 augments Plasmodium falciparum stress responses. AN13762 acts against cultured and fresh Plasmodium falciparum isolates and in vivo murine malaria models. AN13762 can be used for the research of malaria.

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No. CAS: 2025371-99-5
Fòrmula: C₁₇H₁₈BN₃O₅
Peso molecular:355.15

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AN13762 Chemical Structure

No. CAS: 2025371-99-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

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In Vitro

AN13762 (1 nM-10 μM; 48 h) potently inhibits the growth of Plasmodium falciparum laboratory strains (3D7, W2, Dd2, 7G8, VS1, K1, D6) with IC₅₀ values ranging from 18 nM to 118 nM^[1].
AN13762 (72 h) potently inhibits the growth of fresh Plasmodium falciparum clinical isolates from Uganda^[1].
AN13762 (500 nM; 8 h) exhibits the greatest antimalarial activity against ring- and trophozoite-stage Plasmodium falciparum Dd2 parasites, causing abnormal trophozoite morphology and preventing further development^[1].
AN13762 produces low-level resistant Plasmodium falciparum (Dd2, 3D7, W2) with PfPARE mutations (IC₅₀ = 180-1340 nM) and high-level resistant parasites with additional ubiquitination/sumoylation or PfCPSF3 mutations (IC₅₀ = 1.1-5.0 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2025371-99-5
Peso molecular 355.15
Fòrmula C₁₇H₁₈BN₃O₅
SMILES

O=C(N1CC(C)(C1)O)C2=CN=C(OC3=CC=C4C(B(OC4)O)=C3C)C=N2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Sindhe KMV, et al. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020;11(1):e02640-19. Published 2020 Jan 28. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AN13762

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