Anticancer agent 105
Anticancer agent 105 is a compound based on thienopyrimidine scaffold, with with good safety and anticancer properties. Anticancer agent 105 shows selective toxicity towards melanoma cancer, and induces apoptosis. And Anticancer agent 105 significantly inhibits the metastatic nodules, even in pulmonary metastatic melanoma mouse model.
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- No. CAS: 2450987-57-0
- Fòrmula: C25H24KN3O6S
- Peso molecular:533.64
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
3.8 μM
Compound: 9cb
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Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| B16-F10 | IC50 |
2.41 μM
Compound: 9cb
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Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| CT26 | IC50 |
4.3 μM
Compound: 9cb
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Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| MEF | IC50 |
>100 μM
Compound: 9cb
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Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
Anticancer agent 105 (compound 9cb) shows selectivity against cancer cells, while it inhibits survival of cancerous cells (B16–F10 melanoma) and normal non-cancerous fibroblasts (MEF NF2) with IC50s of 2.41 μM, and >100 μM, respectively[1].
Anticancer agent 105 (0.5-10 μM; 24 h) shows toxicity against cancer cells, and (5-20 μM; 48 h) induces apoptosis and necrosis in B16-F10 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16-F10 melanoma
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Concentration:0.5 μM, 1 μM, 5 μM, and 10 μM
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Incubation Time:24 h
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Result:Exhibited very low toxicity or were non-toxic in the case of MEF NF2 cells in the range of concentration 0.2-55 μM.
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Cell Line:B16-F10 melanoma
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Concentration:5 μM, 10 μM, 15 μM, and 20 μM
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Incubation Time:48 h
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Result:Induced early apoptosis and resulted nuclear condensation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pulmonary metastatic melanoma mouse model[1]
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Dosage:I: 9-9.5 mg/kg; II: 42-4.6 mg/kg
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Administration:IP; once daily every 3rd d for 22 d
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Result:Decreased the number of metastatic nodules in mouse.
Chemical Information
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No. CAS 2450987-57-0
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Peso molecular 533.64
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Fòrmula C25H24KN3O6S
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SMILES
O=C(OCC)C1=C(NC(/C(O[K])=C(C(N)=O)\C#N)=C\C(C2=CC=C(OC)C=C2)=O)SC3=C1CCCC3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 105 Related Classifications
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