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Referencia número: HY-155543

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Anticancer agent 135

Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2957914-60-0
Fòrmula: C₂₃H₂₁F₃N₄OS
Peso molecular:458.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 135 Chemical Structure

No. CAS: 2957914-60-0

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	>50 μM Compound: 26h	Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37209451]
LNCaP	IC₅₀	3.5 μM Compound: 26h	Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37209451]

Chemical Information

No. CAS 2957914-60-0
Peso molecular 458.50
Fòrmula C₂₃H₂₁F₃N₄OS
SMILES

FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Xiujin Chang, et al. Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer. Eur J Med Chem. 2023 Sep 5;257:115490. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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