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Referencia número: HY-139828

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Anticancer agent 14

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

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No. CAS: 2762698-14-4
Fòrmula: C₂₉H₃₄N₂O₃
Peso molecular:458.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 14 Chemical Structure

No. CAS: 2762698-14-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

Cellular Effect

Cell Line	Type	Value	Description	References
LA7	IC₅₀	0.19 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.24 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.66 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>18 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.2 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.3 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.65 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]

Chemical Information

No. CAS 2762698-14-4
Peso molecular 458.59
Fòrmula C₂₉H₃₄N₂O₃
SMILES

COC(C=C1)=CC=C1C[C@H]2COC3=CC=CC=C3N2CC4=CC=C(OCCN5CCCC5)C=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jana AK, et al. Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer. J Med Chem. 2021 Nov 11;64(21):16293-16316. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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