Anticancer agent 285
Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC50 = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer[1].
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- No. CAS: 2878446-03-6
- Fòrmula: C12H14N6O2S
- Peso molecular:306.34
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Actividad biológica
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haspin 18 nM (IC50) |
Anticancer agent 285 (Compound 1d) (72 h) exhibits IC50 values of 3.31 μM in SK-Hep-1 cells, 3.91 μM in MDA-MB-231 cells, 4.82 μM in HCT116 cells, 19.7 μM in A549 cells, and 3.58 μM in SNU-638 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCT116 cells (7 × 106 cells per mouse) were injected subcutaneously into the flanks of the Male Balb/c-nu mice (male, aged 4 weeks)[1].
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Dosage:10 mg/kg
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Administration:P.o., i.p., three times per week for 23 days
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Result:The oral administration resulted in a tumor inhibition rate of 51.7%.
The intraperitoneal injection resulted in a tumor inhibition rate of 46.2%.
No significant weight loss or obvious toxicity symptoms were observed in any of the mice.
Chemical Information
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No. CAS 2878446-03-6
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Peso molecular 306.34
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Fòrmula C12H14N6O2S
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SMILES
O[C@@H]1[C@H](O)[C@@H](CN)S[C@H]1N(C2=C3C(N)=NC=N2)C=C3C#N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 285 Related Classifications
HY-179486 Related Classifications
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