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Referencia número: HY-182781

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Anticancer agent 313

Anticancer agent 313 is a MetAP2 inhibitor with an IC₅₀ of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₈H₂₆N₂O₃Si
Peso molecular:346.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 313 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

MetAp2

Ver todos los productos específicos de isoformas MetAP :

In Vitro

Anticancer agent 313 (compound 3) (72 h) inhibits the proliferation of 67nr, 4T1, MDA-MB-231, BxPC3 and MIA PaCa-2 cancer cell lines^[1].
Anticancer agent 313 induces ATF4 expression in 67nr, MDA-MB-231 and MIA PaCa-2 cancer cell lines via an mTORC1-dependent non-canonical (eIF2α phosphorylation-independent) mechanism, but has no such effect in 4T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

67nr, 4T1, MDA-MB-231, BxPC3, MIA PaCa-2 cells
Concentration:

/
Incubation Time:

72 h
Result:

Had IC₅₀ values of 14.4 (67nr), 2.76 (4T1), 17.32 (MDA-MB-231), 16.7 (BxPC3), 9.71 (MIA PaCa-2) μM.

Chemical Information

Peso molecular 346.50
Fòrmula C₁₈H₂₆N₂O₃Si
SMILES

CC(C)[Si](C(C)C)(C(C)C)OC1=CC=C([N+]([O-])=O)C2=CC=CN=C21
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Williams MJ, et al. Nitroxoline-O-protected derivatives inhibit MetAP2 and activate ATF4 through mTORC1 to inhibit cancer cell growth. Bioorg Med Chem Lett. Published online March 28, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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Anticancer agent 313

Ver todos los productos específicos de isoformas MetAP