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Referencia número: HY-146467

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Anticancer agent 62

Anticancer agent 62 (compound 4c) is a potent anticancer agent. Anticancer agent 62 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC₅₀ values of 0.019, 0.060 and 0.016 μM, respectively. Anticancer agent 62 shows effective tumor growth inhibition.

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No. CAS: 2413148-58-8
Fòrmula: C₂₀H₁₈N₃Na₂O₈PS
Peso molecular:537.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 62 Chemical Structure

No. CAS: 2413148-58-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	0.06 μM Compound: 4c	Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
HepG2	IC₅₀	0.019 μM Compound: 4c	Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
MCF7	IC₅₀	0.016 μM Compound: 4c	Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay	[PMID: 32113125]

In Vivo

Anticancer agent 62 (compound 4c) (BALB/c mice, 0-50 mg/kg, IP, once) inhibits human HepG2 xenograft mouse tumor growth by 71.7% at 25 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2413148-58-8
Peso molecular 537.39
Fòrmula C₂₀H₁₈N₃Na₂O₈PS
SMILES

COC1=NC(OC)=C(C=C1)NS(=O)(C2=CC3=C(N(C4=C3C=CC(OP(O[Na])(O[Na])=O)=C4)C)C=C2)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liu Y, et al. Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. Eur J Med Chem. 2020 Apr 1;191:112181. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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