Anticancer agent 99
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2914922-83-9
- Fòrmula: C19H20F3N3O2
- Peso molecular:379.38
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Anticancer agent 99 (0-50 μM, 24 h) directly upregulates Bax expression and induces caspase-3-dependent apoptosis in HepG2 cell line, with antiproliferative effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cell
-
Concentration:25, 50 μM
-
Incubation Time:24 h
-
Result:Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes.
Reduced Akt protein levels in HepG2 cells.
Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.
Chemical Information
-
No. CAS 2914922-83-9
-
Peso molecular 379.38
-
Fòrmula C19H20F3N3O2
-
SMILES
O=C(C1=CC=C(NCCCC)C=C1)N/N=C/C2=C(OC(F)(F)F)C=CC=C2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 99 Related Classifications
HY-149061 Related Classifications
Powered by Bioz