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Referencia número: HY-143487

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Antimalarial agent 12

Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli.

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No. CAS: 2715225-58-2
Fòrmula: C₂₆H₁₈BrClN₂O₂
Peso molecular:505.79

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antimalarial agent 12 Chemical Structure

No. CAS: 2715225-58-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

Plasmodium

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>50000 nM Compound: (R)-3b	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay	[PMID: 35300082]
Hepatocyte	CC₅₀	>10000 nM Compound: (R)-3b	Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay	[PMID: 35300082]

Chemical Information

No. CAS 2715225-58-2
Peso molecular 505.79
Fòrmula C₂₆H₁₈BrClN₂O₂
SMILES

O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hanan Almolhim, et al. Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro. ACS Med Chem Lett. 2022 Feb 24;13(3):371-376. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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