AP-C5
Based on 1 Customer Validation
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease. AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.30%
- No. CAS: 2234272-10-5
- Fòrmula: C16H13N5
- Peso molecular:275.31
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
pIC50: 7.2 (cGKII)[1]
AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue[1].
AP-C5 potentiates cAMP signaling by PDE inhibition[1].
AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2234272-10-5
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Appearance Solid
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Peso molecular 275.31
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Fòrmula C16H13N5
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Color Light yellow to light brown
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SMILES
C#CCNC1=NC=CC(C2=CC=C(N3C=CN=C3)C=C2)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (90.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6323 mL | 18.1613 mL | 36.3227 mL | 90.8067 mL |
| 5 mM | 0.7265 mL | 3.6323 mL | 7.2645 mL | 18.1613 mL | |
| 10 mM | 0.3632 mL | 1.8161 mL | 3.6323 mL | 9.0807 mL | |
| 15 mM | 0.2422 mL | 1.2108 mL | 2.4215 mL | 6.0538 mL | |
| 20 mM | 0.1816 mL | 0.9081 mL | 1.8161 mL | 4.5403 mL | |
| 25 mM | 0.1453 mL | 0.7265 mL | 1.4529 mL | 3.6323 mL | |
| 30 mM | 0.1211 mL | 0.6054 mL | 1.2108 mL | 3.0269 mL | |
| 40 mM | 0.0908 mL | 0.4540 mL | 0.9081 mL | 2.2702 mL | |
| 50 mM | 0.0726 mL | 0.3632 mL | 0.7265 mL | 1.8161 mL | |
| 60 mM | 0.0605 mL | 0.3027 mL | 0.6054 mL | 1.5134 mL | |
| 80 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1351 mL |
AP-C5 Related Classifications
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