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Referencia número: HY-183406

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AS15

AS15 is a PDIA1 inhibitor with an IC₅₀ value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma.

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No. CAS: 102616-62-6
Fòrmula: C₂₀H₂₃NO₆
Peso molecular:373.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AS15 Chemical Structure

No. CAS: 102616-62-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

PDIA1

300 nM (IC₅₀)

In Vitro

AS15 reduces the viability of U-87 MG glioblastoma cells, with an IC₅₀ of 18.3 μM^[1].
AS15 (0.3-3 μM; 24 h) reduces the colony-forming ability of U-118 MG glioblastoma cells, and its activity can be enhanced by glutathione depletion via pre-treatment with BSO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

U-118 MG glioblastoma cells
Concentration:

0.3, 1 and 3 μM
Incubation Time:

24 h (BSO pretreatment)
Result:

Increased potency in reducing colony formation after pretreatment with BSO (a glutathione synthesis inhibitor), supporting that glutathione depletion sensitizes glioblastoma cells to AS15.

Chemical Information

No. CAS 102616-62-6
Peso molecular 373.40
Fòrmula C₂₀H₂₃NO₆
SMILES

OC1=C(C(N2CCOCC2)C3=CC=C(C(OC)=C3)OC)C=C4OCOC4=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Shergalis A, et al. Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines. Journal of medicinal chemistry. 2020 Sep 24;63(18):10263-10286. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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