ATV399
ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes.
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- No. CAS: 393834-37-2
- Fòrmula: C24H23N3O5S
- Peso molecular:465.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
ATV399 (0.04-5 μM; 48 h) inhibits the activation of cytokine-induced active caspase-9 with an IC50 of 3.3 μM. Meanwhile, in rat insulin-secreting INS1E cells treated with pro-inflammatory cytokines and high glucose, this compound fully preserves cell viability, protects insulin secretion function, and reduces endoplasmic reticulum stress levels and the expression of pro-apoptotic proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat insulin-producing INS1E cells
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Concentration:0.04, 0.2, 1, 5 μM (24 h pretreatment followed by 24 h co-treatment with cytokines); 5 μM (24 h pretreatment followed by 24 h co-treatment with cytokines and high glucose)
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Incubation Time:24 h (pretreatment) + 24 h (co-treatment with cytokines); 24 h (pretreatment) + 24 h (co-treatment with cytokines and high glucose)
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Result:Dose-dependently inhibited cytokine-induced cleaved caspase-9 activation with an IC50 of 3.3 μM.
Fully prevented the 60% reduction in cell viability caused by cytokines at 5 μM.
Restored insulin secretion levels.
Significantly reduced cytokine-induced upregulation of ER stress-related genes including ATF4, ATF6, BiP, CHOP, protein disulfide isomerase, and sXBP1 at 5 μM.
Decreased protein levels of the pro-apoptotic markers CHOP and cleaved caspase-3 at 5 μM.
Chemical Information
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No. CAS 393834-37-2
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Peso molecular 465.52
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Fòrmula C24H23N3O5S
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SMILES
O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C=3C=NC=CC3)C4=CC=C5OCOC5=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATV399 Related Classifications
HY-119119 Related Classifications
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