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Batracylin

(Synonyms: NSC 320846; BAY-H 2049)

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks.

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No. CAS: 67199-66-0
Fòrmula: C₁₅H₁₁N₃O
Peso molecular:249.27

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Batracylin Chemical Structure

No. CAS: 67199-66-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	46.3 μM Compound: BAT; Batracylin	Cytotoxicity against human A549 cells after 120 hrs by MTT assay Cytotoxicity against human A549 cells after 120 hrs by MTT assay	[PMID: 26520842]
CCRF-CEM	IC₅₀	14 μM Compound: 1	Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells	[PMID: 7932571]
HCT-116	IC₅₀	88.7 μM Compound: BAT; Batracylin	Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay	[PMID: 26520842]
HL-60	IC₅₀	66.6 μM Compound: BAT; Batracylin	Cytotoxicity against human HL60 cells after 120 hrs by MTT assay Cytotoxicity against human HL60 cells after 120 hrs by MTT assay	[PMID: 26520842]
HT-29	IC₅₀	64.3 μM Compound: BAT; Batracylin	Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay	[PMID: 26520842]
L1210	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay	[PMID: 26520842]
LNCaP	IC₅₀	90.2 μM Compound: BAT; Batracylin	Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay	[PMID: 26520842]
MCF7	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay	[PMID: 26520842]
NIH3T3	IC₅₀	69.9 μM Compound: BAT; Batracylin	Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay	[PMID: 26520842]
P388	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay	[PMID: 26520842]

In Vitro

Batracylin (0-300 µM; 6 h) shows cytotoxicity with an IC₅₀ value of 10.02 µM for HT29 cells^[1].
Batracylin (100, 300 µM; 3 h) induces protein-linked DNA breaks consistent with topoisomerase targeting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 67199-66-0
Peso molecular 249.27
Fòrmula C₁₅H₁₁N₃O
SMILES

O=C1C2=C(C=CC=C2)C3=NC4=C(CN31)C=C(C=C4)N
Synonyms

NSC 320846; BAY-H 2049
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- Ensayo clínico
Chemical Information
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Referencias

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Batracylin

Ver todos los productos específicos de isoformas Topoisomerase