BMV109
BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1458731-58-2
- Fòrmula: C107H108F4N10O23S5
- Peso molecular:2138.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
BMV109 (compound 8; 0.05 µM, 0.1 µM, 0.5 µM, 1 µM, 5 µM) labels all target cysteine cathepsins (B, S, L, X) with equal intensity in living RAW cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice bearing 4T1 cells[1]
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Dosage:20 nmol
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Administration:Tail vein
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Result:Robust tumor specific activation of fluorescence with high overall intensity could be observed.
Chemical Information
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No. CAS 1458731-58-2
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Peso molecular 2138.37
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Fòrmula C107H108F4N10O23S5
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SMILES
O=S(C1=C(C=CC=C1)C(C2=CC=C(N3C4=CC=C(S(=O)([O-])=O)C=C4CC3)C=C2O5)=C(C=C/6)C5=CC6=[N+]7C8=CC=C(S(=O)(O)=O)C=C8CC/7)(N9CCC(CC9)C(NCCNC(C%10=C(C(F)=C(C(F)=C%10F)OCC([C@H](CCCCNC(CCCCCN%11C%12=CC=C(S(=O)(O)=O)C=C%12C(C)(/C%11=C/C=C/C=C/C%13=[N+](C%14=CC=C(S(=O)([O-])=O)C=C%14C%13(C)C)CC)C)=O)NC([C@@H](NC(OCC%15=CC=CC=C%15)=O)CC%16=CC=CC=C%16)=O)=O)F)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Martijn Verdoes, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013 Oct 2;135(39):14726-30. [Content Brief]
[2]. Steven Sensarn, et al. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18(6):820-829. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMV109 Related Classifications
HY-149931 Related Classifications
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