BPH252
BPH252 (Compound 4) is a geranylgeranyl diphosphate synthase inhibitor. BPH252 can be used in research on bisphosphonate-based anticancer inhibitors.
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- No. CAS: 2809-23-6
- Fòrmula: C10H24O7P2
- Peso molecular:318.24
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | IC50 |
0.83 μM
Compound: NBP8
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Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis
Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis
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[PMID: 33522236] |
| HFF | IC50 |
0.55 μM
Compound: 2
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In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)
In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)
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[PMID: 15857119] |
| HFF | IC50 |
0.57 μM
Compound: 2
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Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.15 uM, experiment 2)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.15 uM, experiment 2)
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[PMID: 15857119] |
| HFF | IC50 |
1.7 μM
Compound: 2
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Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.55 uM, experiment 3)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.55 uM, experiment 3)
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[PMID: 15857119] |
| HFF | IC50 |
1.9 μM
Compound: 2
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Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.62 uM, experiment 1)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.62 uM, experiment 1)
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[PMID: 15857119] |
| KB | ED50 |
892 μM
Compound: 72
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Dose to inhibit the growth of human KB carcinoma cell line
Dose to inhibit the growth of human KB carcinoma cell line
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[PMID: 16162013] |
Chemical Information
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No. CAS 2809-23-6
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Peso molecular 318.24
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Fòrmula C10H24O7P2
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SMILES
O=P(O)(O)C(O)(CCCCCCCCC)P(=O)(O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BPH252 Related Classifications
HY-126472 Related Classifications
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