Bremelanotide
Based on 1 publication(s) in Google Scholar
Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders.
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- Pureza : 99.94%
- No. CAS: 189691-06-3
- Fòrmula: C50H68N14O10
- Peso molecular:1025.16
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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SHU 9119MC3/4R Antagonist -
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BPC 157Gastric Pentadecapeptide -
HY-P2048
MOTS-c (human)Bioactive Peptide -
HY-114118
SemaglutideGLP-1R Agonist -
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SemaxNeuroprotective Peptide -
HY-P0170
TB500Thymosin β 4 Synthetic Molecule -
HY-B0445
NAD+Endogenous Metabolite -
HY-P0252
α-MSHMC4R Agonist
Publications Citing Use of MedChemExpress (MCE) Bremelanotide
More
Actividad biológica
Descripciòn
IC50 & Target
[3]|
MC4R |
MC3R |
In Vitro
Bremelanotide (10−3-105 nM) binds to MC3R and MC4R in a concentration-dependent manner[3].
Bremelanotide induces cAMP accumulation in cell-free assays with EC50 values of 0.4 nM for MC3R and 0.2 nM for MC4R[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)[1]
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Dosage:50, 100, 200 μg/kg
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Administration:Subcutaneously injection
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Result:Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Increased solicitations in estradiol-alone primed rats at 200 μg/kg.
Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Induced female mounting behavior at 200 μg/kg.
Chemical Information
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No. CAS 189691-06-3
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Appearance Solid
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Peso molecular 1025.16
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Fòrmula C50H68N14O10
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Color White to off-white
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Synonyms
PT-141
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Pharm
2022 Nov 7;19(11):4320-4332. PMID: 36269563
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (97.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007;4 Suppl 4:269-279. [Content Brief]
[3]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9755 mL | 4.8773 mL | 9.7546 mL | 24.3864 mL |
| 5 mM | 0.1951 mL | 0.9755 mL | 1.9509 mL | 4.8773 mL | |
| 10 mM | 0.0975 mL | 0.4877 mL | 0.9755 mL | 2.4386 mL | |
| 15 mM | 0.0650 mL | 0.3252 mL | 0.6503 mL | 1.6258 mL | |
| 20 mM | 0.0488 mL | 0.2439 mL | 0.4877 mL | 1.2193 mL | |
| 25 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9755 mL | |
| 30 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8129 mL | |
| 40 mM | 0.0244 mL | 0.1219 mL | 0.2439 mL | 0.6097 mL | |
| 50 mM | 0.0195 mL | 0.0975 mL | 0.1951 mL | 0.4877 mL | |
| 60 mM | 0.0163 mL | 0.0813 mL | 0.1626 mL | 0.4064 mL | |
| 80 mM | 0.0122 mL | 0.0610 mL | 0.1219 mL | 0.3048 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Bremelanotide Related Classifications
HY-18678 Related Classifications
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